Immature Brain Cortical Neurons Have Low Transcriptional Competence to Activate Antiviral Defences and Control RNA Virus Infections

Immature Brain Cortical Neurons Have Low Transcriptional Competence to Activate Antiviral Defences and Control RNA Virus Infections

Virus infections of the central nervous system (CNS) cause important diseases of humans and animals. As in other tissues, innate antiviral responses mediated by type I interferons (IFNs) are crucially important in controlling CNS virus infections. The maturity of neuronal populations is an establish...

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Bibliographic Details
Main Authors: Divya Narayanan, Nagaraj Moily, Hayley A. McQuilten, Katherine Kedzierska, Jason M. Mackenzie, Lukasz Kedzierski, John K. Fazakerley
Format: Article
Language:English
Published: Karger Publishers 2022-06-01
Series:Journal of Innate Immunity
Subjects:
alphavirus
interferon
neuron
innate immunity
Online Access:https://www.karger.com/Article/FullText/525291

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