Lysosomal P-gp-MDR1 Confers Drug Resistance of Brentuximab Vedotin and Its Cytotoxic Payload Monomethyl Auristatin E in Tumor Cells

Lysosomal P-gp-MDR1 Confers Drug Resistance of Brentuximab Vedotin and Its Cytotoxic Payload Monomethyl Auristatin E in Tumor Cells

Antibody-drug conjugates (ADCs) are composed of an antibody linked to cytotoxic anticancer payloads. ADCs recognize tumor-specific cell surface antigens and are internalized into lysosomes where proteolytic enzymes release the cytotoxic payloads. Efflux transporters on plasma membrane that play a si...

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Bibliographic Details
Main Authors: Peggy Liu-Kreyche, Hong Shen, Anthony M. Marino, Ramaswamy A. Iyer, W. Griffith Humphreys, Yurong Lai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
antibody drug conjugates
P-glycoprotein (P-gp-MDR1)
multidrug resistance
cytotoxicity
monomethyl auristatin E
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00749/full

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