Astrocytes as the main players in Primary Degenerative Disorders of the Human Central Nervous System
Along the last years it has been demonstrated that non-neural cells play a major role in the pathogenesis of the Primary Degenerative Disorders (PDD) of the human central nervous system. Among them, astrocytes coordinate and participate in many different and complex metabolic processes, in close int...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-03-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00045/full |
| _version_ | 1818538564547248128 |
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| author | Francisco eCapani Francisco eCapani Cecilia eQuarracino Roberto eCaccuri Roberto Ernesto Pedro Sica |
| author_facet | Francisco eCapani Francisco eCapani Cecilia eQuarracino Roberto eCaccuri Roberto Ernesto Pedro Sica |
| author_sort | Francisco eCapani |
| collection | DOAJ |
| description | Along the last years it has been demonstrated that non-neural cells play a major role in the pathogenesis of the Primary Degenerative Disorders (PDD) of the human central nervous system. Among them, astrocytes coordinate and participate in many different and complex metabolic processes, in close interaction with neurons. Moreover, increasing experimental evidence hints an early astrocytic dysfunction in these diseases. In this mini review we summarize the astrocytic behavior in PDDs, with special consideration to the experimental observations where astrocytic pathology precedes the development of neuronal dysfunction. We also suggest a different approach that could be consider in human investigations in Alzheimer’s and Parkinson's disease. We believe that the study of PDDs with human brain samples may hold the key of a paradigmatic physiopathological process in which astrocytes might be the main players. |
| first_indexed | 2024-12-11T21:30:35Z |
| format | Article |
| id | doaj.art-88537b2f6c1a46e99e1bab09df08e933 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-11T21:30:35Z |
| publishDate | 2016-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-88537b2f6c1a46e99e1bab09df08e9332022-12-22T00:50:11ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-03-01810.3389/fnagi.2016.00045180514Astrocytes as the main players in Primary Degenerative Disorders of the Human Central Nervous SystemFrancisco eCapani0Francisco eCapani1Cecilia eQuarracino2Roberto eCaccuri3Roberto Ernesto Pedro Sica4Instituto de Investigaciones Cardiologicas ININCA UBA CONICETUniversidad Autónoma de ChileUniversidad Autónoma de ChileUniversidad Autónoma de ChileUniversidad Autónoma de ChileAlong the last years it has been demonstrated that non-neural cells play a major role in the pathogenesis of the Primary Degenerative Disorders (PDD) of the human central nervous system. Among them, astrocytes coordinate and participate in many different and complex metabolic processes, in close interaction with neurons. Moreover, increasing experimental evidence hints an early astrocytic dysfunction in these diseases. In this mini review we summarize the astrocytic behavior in PDDs, with special consideration to the experimental observations where astrocytic pathology precedes the development of neuronal dysfunction. We also suggest a different approach that could be consider in human investigations in Alzheimer’s and Parkinson's disease. We believe that the study of PDDs with human brain samples may hold the key of a paradigmatic physiopathological process in which astrocytes might be the main players.http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00045/fullAstrocytesPriapismneurodegenerationprimary degenerative disordershuman central nervous system |
| spellingShingle | Francisco eCapani Francisco eCapani Cecilia eQuarracino Roberto eCaccuri Roberto Ernesto Pedro Sica Astrocytes as the main players in Primary Degenerative Disorders of the Human Central Nervous System Frontiers in Aging Neuroscience Astrocytes Priapism neurodegeneration primary degenerative disorders human central nervous system |
| title | Astrocytes as the main players in Primary Degenerative Disorders of the Human Central Nervous System |
| title_full | Astrocytes as the main players in Primary Degenerative Disorders of the Human Central Nervous System |
| title_fullStr | Astrocytes as the main players in Primary Degenerative Disorders of the Human Central Nervous System |
| title_full_unstemmed | Astrocytes as the main players in Primary Degenerative Disorders of the Human Central Nervous System |
| title_short | Astrocytes as the main players in Primary Degenerative Disorders of the Human Central Nervous System |
| title_sort | astrocytes as the main players in primary degenerative disorders of the human central nervous system |
| topic | Astrocytes Priapism neurodegeneration primary degenerative disorders human central nervous system |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00045/full |
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