miR-146a inhibits ovarian tumor growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8+ T cell infiltration

miR-146a inhibits ovarian tumor growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8+ T cell infiltration

Immunotherapies have emerged as promising strategies for cancer treatment. However, existing immunotherapies have poor activity in high-grade serous ovarian cancer (HGSC) due to the immunosuppressive tumor microenvironment and the associated low tumoral CD8+ T cell (CTL) infiltration. Through multip...

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Bibliographic Details
Main Authors: Rui Chen, Elaina Coleborn, Chintan Bhavsar, Yue Wang, Louisa Alim, Andrew N. Wilkinson, Michelle A. Tran, Gowri Irgam, Sharat Atluri, Kiefer Wong, Jae-Jun Shim, Siddharth Adityan, Ju-Seog Lee, Willem W. Overwijk, Raymond Steptoe, Da Yang, Sherry Y. Wu
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
ovarian cancer
microRNAs
tumor microenvironment
nanotherapeutics
immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770523000700

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