Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies
Cardiovascular diseases, including coronary artery disease, ischemic heart diseases such as acute myocardial infarction and postischemic heart failure, heart failure of other etiologies, and cardiac arrhythmias, belong to the leading causes of death. Activation of capsaicin-sensitive sensory nerves...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/12/4472 |
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| author | Tamara Szabados Kamilla Gömöri Laura Pálvölgyi Anikó Görbe István Baczkó Zsuzsanna Helyes Gábor Jancsó Péter Ferdinandy Péter Bencsik |
| author_facet | Tamara Szabados Kamilla Gömöri Laura Pálvölgyi Anikó Görbe István Baczkó Zsuzsanna Helyes Gábor Jancsó Péter Ferdinandy Péter Bencsik |
| author_sort | Tamara Szabados |
| collection | DOAJ |
| description | Cardiovascular diseases, including coronary artery disease, ischemic heart diseases such as acute myocardial infarction and postischemic heart failure, heart failure of other etiologies, and cardiac arrhythmias, belong to the leading causes of death. Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles. Capsaicin-sensitive sensory nerves also contribute to the development and progression of some cardiac diseases, as well as to mechanisms of endogenous stress adaptation leading to cardioprotection. In this review, we summarize the role of capsaicin-sensitive afferents and the TRPV1 ion channel in physiological and pathophysiological functions of the heart based mainly on experimental results and show their diagnostic or therapeutic potentials. Although the actions of several other channels or receptors expressed on cardiac sensory afferents and the effects of TRPV1 channel activation on different non-neural cell types in the heart are not precisely known, most data suggest that stimulation of the TRPV1-expressing sensory nerves or stimulation/overexpression of TRPV1 channels have beneficial effects in cardiac diseases. |
| first_indexed | 2024-03-10T18:56:27Z |
| format | Article |
| id | doaj.art-88558d59b0434c64b8b00f08af582d3a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:56:27Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-88558d59b0434c64b8b00f08af582d3a2023-11-20T04:45:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-06-012112447210.3390/ijms21124472Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and PathologiesTamara Szabados0Kamilla Gömöri1Laura Pálvölgyi2Anikó Görbe3István Baczkó4Zsuzsanna Helyes5Gábor Jancsó6Péter Ferdinandy7Péter Bencsik8Cardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, H-6720 Szeged, HungaryCardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, H-6720 Szeged, HungaryDepartment of Physiology, Faculty of Medicine, University of Szeged, H-6720 Szeged, HungaryCardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, H-6720 Szeged, HungaryCardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, H-6720 Szeged, HungaryDepartment of Pharmacology and Pharmacotherapy, Medical School & Molecular Pharmacology Research Group, Centre for Neuroscience, János Szentágothai Research Centre, University of Pécs, H-7624 Pécs, HungaryDepartment of Physiology, Faculty of Medicine, University of Szeged, H-6720 Szeged, HungaryDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, HungaryCardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, H-6720 Szeged, HungaryCardiovascular diseases, including coronary artery disease, ischemic heart diseases such as acute myocardial infarction and postischemic heart failure, heart failure of other etiologies, and cardiac arrhythmias, belong to the leading causes of death. Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles. Capsaicin-sensitive sensory nerves also contribute to the development and progression of some cardiac diseases, as well as to mechanisms of endogenous stress adaptation leading to cardioprotection. In this review, we summarize the role of capsaicin-sensitive afferents and the TRPV1 ion channel in physiological and pathophysiological functions of the heart based mainly on experimental results and show their diagnostic or therapeutic potentials. Although the actions of several other channels or receptors expressed on cardiac sensory afferents and the effects of TRPV1 channel activation on different non-neural cell types in the heart are not precisely known, most data suggest that stimulation of the TRPV1-expressing sensory nerves or stimulation/overexpression of TRPV1 channels have beneficial effects in cardiac diseases.https://www.mdpi.com/1422-0067/21/12/4472acute myocardial infarctionarrhythmiaatherosclerosiscapsaicincardioprotectionischemic heart disease |
| spellingShingle | Tamara Szabados Kamilla Gömöri Laura Pálvölgyi Anikó Görbe István Baczkó Zsuzsanna Helyes Gábor Jancsó Péter Ferdinandy Péter Bencsik Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies International Journal of Molecular Sciences acute myocardial infarction arrhythmia atherosclerosis capsaicin cardioprotection ischemic heart disease |
| title | Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies |
| title_full | Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies |
| title_fullStr | Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies |
| title_full_unstemmed | Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies |
| title_short | Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies |
| title_sort | capsaicin sensitive sensory nerves and the trpv1 ion channel in cardiac physiology and pathologies |
| topic | acute myocardial infarction arrhythmia atherosclerosis capsaicin cardioprotection ischemic heart disease |
| url | https://www.mdpi.com/1422-0067/21/12/4472 |
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