Circulating fibrocyte levels correlate with infarct size in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention
Study objective: Infarct size is a strong predictor of outcomes after ST elevation myocardial infarction (STEMI). Circulating fibrocytes are bone marrow-derived progenitor cells associated with fibrotic processes. We tested whether fibrocytes correlate with infarct size in STEMI patients treated wit...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | American Heart Journal Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602221000690 |
| _version_ | 1828941062316490752 |
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| author | Mohammed Elzeneini Mohammad Al-Ani Anthony E. Peters Marie D. Burdick Ning Yang Michael Salerno Borna Mehrad Ellen C. Keeley |
| author_facet | Mohammed Elzeneini Mohammad Al-Ani Anthony E. Peters Marie D. Burdick Ning Yang Michael Salerno Borna Mehrad Ellen C. Keeley |
| author_sort | Mohammed Elzeneini |
| collection | DOAJ |
| description | Study objective: Infarct size is a strong predictor of outcomes after ST elevation myocardial infarction (STEMI). Circulating fibrocytes are bone marrow-derived progenitor cells associated with fibrotic processes. We tested whether fibrocytes correlate with infarct size in STEMI patients treated with primary percutaneous coronary intervention (PCI). Design: Prospective observational study. Setting: Academic medical center. Participants: Subjects with STEMI treated with primary PCI. Interventions: Peripheral blood draw and cardiac magnetic resonance imaging (CMR). Main outcome measure: Correlation of fibrocyte levels with infarct size. Methods: Peripheral blood fibrocytes were quantified at discharge from STEMI hospitalization and at 6 months follow-up using flow cytometry. Infarct size was determined within 2 weeks of discharge and at 6 months follow-up using late gadolinium enhancement on CMR. Results: Among 14 patients (median age 54 years, 79% men) with STEMI, there was a statistically significant positive correlation between fibrocyte levels at 6 months and 6-month infarct size on CMR (r = 0.58, p = 0.031). In addition, there was positive correlation between peak troponin I level (r = 0.85, p < 0.001), and white blood cell count (r = 0.55, p = 0.042) during the hospital stay and 6-month infarct size on CMR. Conclusions: Circulating fibrocytes measured 6 months after STEMI positively correlate with 6-month infarct size assessed by CMR. |
| first_indexed | 2024-12-14T03:30:42Z |
| format | Article |
| id | doaj.art-885651fbc262405490159c1f33a51881 |
| institution | Directory Open Access Journal |
| issn | 2666-6022 |
| language | English |
| last_indexed | 2024-12-14T03:30:42Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj.art-885651fbc262405490159c1f33a518812022-12-21T23:18:47ZengElsevierAmerican Heart Journal Plus2666-60222021-12-0112100071Circulating fibrocyte levels correlate with infarct size in patients with ST elevation myocardial infarction treated with primary percutaneous coronary interventionMohammed Elzeneini0Mohammad Al-Ani1Anthony E. Peters2Marie D. Burdick3Ning Yang4Michael Salerno5Borna Mehrad6Ellen C. Keeley7Department of Medicine, University of Florida, Gainesville, FL, USA; Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USADepartment of Medicine, University of Florida, Gainesville, FL, USA; Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USADepartment of Internal Medicine, University of Virginia, Charlottesville, VA, USADepartment of Internal Medicine, University of Virginia, Charlottesville, VA, USADepartment of Medicine, University of Florida, Gainesville, FL, USA; Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USADepartment of Internal Medicine, University of Virginia, Charlottesville, VA, USA; Division of Cardiovascular Medicine, University of Virginia, Charlottesville, VA, USADepartment of Medicine, University of Florida, Gainesville, FL, USA; Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USADepartment of Medicine, University of Florida, Gainesville, FL, USA; Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA; Corresponding author at: Division of Cardiovascular Medicine, University of Florida, 1600 SW Archer Road, P.O. Box 100277, Gainesville, FL 32610-0277, USA.Study objective: Infarct size is a strong predictor of outcomes after ST elevation myocardial infarction (STEMI). Circulating fibrocytes are bone marrow-derived progenitor cells associated with fibrotic processes. We tested whether fibrocytes correlate with infarct size in STEMI patients treated with primary percutaneous coronary intervention (PCI). Design: Prospective observational study. Setting: Academic medical center. Participants: Subjects with STEMI treated with primary PCI. Interventions: Peripheral blood draw and cardiac magnetic resonance imaging (CMR). Main outcome measure: Correlation of fibrocyte levels with infarct size. Methods: Peripheral blood fibrocytes were quantified at discharge from STEMI hospitalization and at 6 months follow-up using flow cytometry. Infarct size was determined within 2 weeks of discharge and at 6 months follow-up using late gadolinium enhancement on CMR. Results: Among 14 patients (median age 54 years, 79% men) with STEMI, there was a statistically significant positive correlation between fibrocyte levels at 6 months and 6-month infarct size on CMR (r = 0.58, p = 0.031). In addition, there was positive correlation between peak troponin I level (r = 0.85, p < 0.001), and white blood cell count (r = 0.55, p = 0.042) during the hospital stay and 6-month infarct size on CMR. Conclusions: Circulating fibrocytes measured 6 months after STEMI positively correlate with 6-month infarct size assessed by CMR.http://www.sciencedirect.com/science/article/pii/S2666602221000690Infarct sizeST elevation myocardial infarctionFibrocyteBiomarker |
| spellingShingle | Mohammed Elzeneini Mohammad Al-Ani Anthony E. Peters Marie D. Burdick Ning Yang Michael Salerno Borna Mehrad Ellen C. Keeley Circulating fibrocyte levels correlate with infarct size in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention American Heart Journal Plus Infarct size ST elevation myocardial infarction Fibrocyte Biomarker |
| title | Circulating fibrocyte levels correlate with infarct size in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention |
| title_full | Circulating fibrocyte levels correlate with infarct size in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention |
| title_fullStr | Circulating fibrocyte levels correlate with infarct size in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention |
| title_full_unstemmed | Circulating fibrocyte levels correlate with infarct size in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention |
| title_short | Circulating fibrocyte levels correlate with infarct size in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention |
| title_sort | circulating fibrocyte levels correlate with infarct size in patients with st elevation myocardial infarction treated with primary percutaneous coronary intervention |
| topic | Infarct size ST elevation myocardial infarction Fibrocyte Biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S2666602221000690 |
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