Higher Serum E-Selectin Levels Associated with Malignant Brain Edema after Endovascular Thrombectomy for Ischemic Stroke: A Pilot Study
<b>Background and Purpose:</b> Little is known about the effect of soluble adhesion molecules on malignant brain edema (MBE) after endovascular thrombectomy (EVT). This study aimed to explore the association between serum concentrations of E-selectin and the risk of MBE in patients who r...
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MDPI AG
2023-07-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/7/1097 |
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| author | Feng Zhou Mingyang Du Yan E Shuaiyu Chen Wei Wang Hongchao Shi Junshan Zhou Yingdong Zhang |
| author_facet | Feng Zhou Mingyang Du Yan E Shuaiyu Chen Wei Wang Hongchao Shi Junshan Zhou Yingdong Zhang |
| author_sort | Feng Zhou |
| collection | DOAJ |
| description | <b>Background and Purpose:</b> Little is known about the effect of soluble adhesion molecules on malignant brain edema (MBE) after endovascular thrombectomy (EVT). This study aimed to explore the association between serum concentrations of E-selectin and the risk of MBE in patients who received EVT. <b>Methods:</b> Patients with a large vessel occlusion stroke in the anterior circulation who underwent EVT were prospectively recruited. Serum soluble E-selectin concentrations were measured after admission for all patients. MBE was defined as a midline shift of ≥5 mm on follow-up imaging within 72 h after surgery. Multivariate logistic regression analyses were performed to determine the association between E-selectin levels and the risk of MBE. <b>Results:</b> Among the 261 included patients (mean age, 69.7 ± 12.3 years; 166 males), 59 (22.6%) developed MBE. Increasing circulating E-selectin levels were associated with an increased risk of MBE after multivariable adjustment (odds ratios [OR], highest vs. lowest quartile: 3.593; 95% confidence interval [CI], 1.178−10.956; <i>p</i> = 0.025). We further observed a significantly positive association between E-selectin and MBE (per 1-standard deviation increase; OR, 1.988; 95% CI, 1.379−2.866, <i>p</i> = 0.001) when the E-selectin levels were analyzed as a continuous variable. Furthermore, the restricted cubic spline demonstrated a linear correlation between serum E-selectin levels and the risk of MBE (<i>p</i> < 0.001 for linearity). <b>Conclusions</b>: In this prospective study, circulating levels of E-selectin were associated with an increased risk of MBE after EVT. Further mechanistic studies are warranted to elucidate the pathophysiology underlying this association. |
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| language | English |
| last_indexed | 2024-03-11T01:14:44Z |
| publishDate | 2023-07-01 |
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| series | Brain Sciences |
| spelling | doaj.art-885a93a3a4ee4ab69b1dba2a932c5f3b2023-11-18T18:35:20ZengMDPI AGBrain Sciences2076-34252023-07-01137109710.3390/brainsci13071097Higher Serum E-Selectin Levels Associated with Malignant Brain Edema after Endovascular Thrombectomy for Ischemic Stroke: A Pilot StudyFeng Zhou0Mingyang Du1Yan E2Shuaiyu Chen3Wei Wang4Hongchao Shi5Junshan Zhou6Yingdong Zhang7Department of Neurology, Nanjing First Hospital, Nanjing Medical University, No. 86 Changle Road, Nanjing 210000, ChinaDepartment of Neurology, Cerebrovascular Disease Center, Nanjing Brain Hospital Affiliated to Nanjing Medical University, No. 264 Guangzhou Road, Nanjing 210029, ChinaDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, No. 86 Changle Road, Nanjing 210000, ChinaDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, No. 86 Changle Road, Nanjing 210000, ChinaDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, No. 86 Changle Road, Nanjing 210000, ChinaDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, No. 86 Changle Road, Nanjing 210000, ChinaDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, No. 86 Changle Road, Nanjing 210000, ChinaDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, No. 86 Changle Road, Nanjing 210000, China<b>Background and Purpose:</b> Little is known about the effect of soluble adhesion molecules on malignant brain edema (MBE) after endovascular thrombectomy (EVT). This study aimed to explore the association between serum concentrations of E-selectin and the risk of MBE in patients who received EVT. <b>Methods:</b> Patients with a large vessel occlusion stroke in the anterior circulation who underwent EVT were prospectively recruited. Serum soluble E-selectin concentrations were measured after admission for all patients. MBE was defined as a midline shift of ≥5 mm on follow-up imaging within 72 h after surgery. Multivariate logistic regression analyses were performed to determine the association between E-selectin levels and the risk of MBE. <b>Results:</b> Among the 261 included patients (mean age, 69.7 ± 12.3 years; 166 males), 59 (22.6%) developed MBE. Increasing circulating E-selectin levels were associated with an increased risk of MBE after multivariable adjustment (odds ratios [OR], highest vs. lowest quartile: 3.593; 95% confidence interval [CI], 1.178−10.956; <i>p</i> = 0.025). We further observed a significantly positive association between E-selectin and MBE (per 1-standard deviation increase; OR, 1.988; 95% CI, 1.379−2.866, <i>p</i> = 0.001) when the E-selectin levels were analyzed as a continuous variable. Furthermore, the restricted cubic spline demonstrated a linear correlation between serum E-selectin levels and the risk of MBE (<i>p</i> < 0.001 for linearity). <b>Conclusions</b>: In this prospective study, circulating levels of E-selectin were associated with an increased risk of MBE after EVT. Further mechanistic studies are warranted to elucidate the pathophysiology underlying this association.https://www.mdpi.com/2076-3425/13/7/1097E-selectinbrain edemaendovascular therapyacute ischemic stroke |
| spellingShingle | Feng Zhou Mingyang Du Yan E Shuaiyu Chen Wei Wang Hongchao Shi Junshan Zhou Yingdong Zhang Higher Serum E-Selectin Levels Associated with Malignant Brain Edema after Endovascular Thrombectomy for Ischemic Stroke: A Pilot Study Brain Sciences E-selectin brain edema endovascular therapy acute ischemic stroke |
| title | Higher Serum E-Selectin Levels Associated with Malignant Brain Edema after Endovascular Thrombectomy for Ischemic Stroke: A Pilot Study |
| title_full | Higher Serum E-Selectin Levels Associated with Malignant Brain Edema after Endovascular Thrombectomy for Ischemic Stroke: A Pilot Study |
| title_fullStr | Higher Serum E-Selectin Levels Associated with Malignant Brain Edema after Endovascular Thrombectomy for Ischemic Stroke: A Pilot Study |
| title_full_unstemmed | Higher Serum E-Selectin Levels Associated with Malignant Brain Edema after Endovascular Thrombectomy for Ischemic Stroke: A Pilot Study |
| title_short | Higher Serum E-Selectin Levels Associated with Malignant Brain Edema after Endovascular Thrombectomy for Ischemic Stroke: A Pilot Study |
| title_sort | higher serum e selectin levels associated with malignant brain edema after endovascular thrombectomy for ischemic stroke a pilot study |
| topic | E-selectin brain edema endovascular therapy acute ischemic stroke |
| url | https://www.mdpi.com/2076-3425/13/7/1097 |
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