The Performance of Diagnostic Tests for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the South African Population: A Scoping Review
To determine the performance and reliability of diagnostic tests for the identification of SARS-CoV-2 infection in South Africa, we conducted a scoping review to identify published studies undertaken in the English language from March 2020 to August 2022 that evaluated the performance of antigen- an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/8/12/514 |
| _version_ | 1797379236428775424 |
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| author | Natasha Samsunder Nikita Devnarain Aida Sivro Ayesha B. M. Kharsany |
| author_facet | Natasha Samsunder Nikita Devnarain Aida Sivro Ayesha B. M. Kharsany |
| author_sort | Natasha Samsunder |
| collection | DOAJ |
| description | To determine the performance and reliability of diagnostic tests for the identification of SARS-CoV-2 infection in South Africa, we conducted a scoping review to identify published studies undertaken in the English language from March 2020 to August 2022 that evaluated the performance of antigen- and antibody-based diagnostic tests for SARS-CoV-2 in South Africa. We identified 17 relevant peer-reviewed articles; six reported on SARS-CoV-2 gene and/or antigen detection whilst 11 reported on antibody detection. Of the SARS-CoV-2 gene and/or antigen-based tests, sensitivity ranged from 40% to 100%, whilst for the antibody-based tests, sensitivity ranged from 13% to 100%. All tests evaluated were highly dependent on the stage of infection and the timing of sample collection. This scoping review demonstrated that no single SARS-CoV-2 gene and/or antigen- or antibody-based assay was sufficiently sensitive and specific simultaneously. The sensitivity of the tests was highly dependent on the timing of sample collection with respect to SARS-CoV-2 infection. In the case of SARS-CoV-2 gene and/or antigen detection, the earlier the collection of samples, the greater the sensitivity, while antibody detection tests showed better sensitivity using samples from later stages of infection. |
| first_indexed | 2024-03-08T20:19:15Z |
| format | Article |
| id | doaj.art-885c0cc02d7244268c2f23a1c3edc224 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-08T20:19:15Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-885c0cc02d7244268c2f23a1c3edc2242023-12-22T14:46:27ZengMDPI AGTropical Medicine and Infectious Disease2414-63662023-12-0181251410.3390/tropicalmed8120514The Performance of Diagnostic Tests for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the South African Population: A Scoping ReviewNatasha Samsunder0Nikita Devnarain1Aida Sivro2Ayesha B. M. Kharsany3Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South AfricaCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South AfricaCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South AfricaCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South AfricaTo determine the performance and reliability of diagnostic tests for the identification of SARS-CoV-2 infection in South Africa, we conducted a scoping review to identify published studies undertaken in the English language from March 2020 to August 2022 that evaluated the performance of antigen- and antibody-based diagnostic tests for SARS-CoV-2 in South Africa. We identified 17 relevant peer-reviewed articles; six reported on SARS-CoV-2 gene and/or antigen detection whilst 11 reported on antibody detection. Of the SARS-CoV-2 gene and/or antigen-based tests, sensitivity ranged from 40% to 100%, whilst for the antibody-based tests, sensitivity ranged from 13% to 100%. All tests evaluated were highly dependent on the stage of infection and the timing of sample collection. This scoping review demonstrated that no single SARS-CoV-2 gene and/or antigen- or antibody-based assay was sufficiently sensitive and specific simultaneously. The sensitivity of the tests was highly dependent on the timing of sample collection with respect to SARS-CoV-2 infection. In the case of SARS-CoV-2 gene and/or antigen detection, the earlier the collection of samples, the greater the sensitivity, while antibody detection tests showed better sensitivity using samples from later stages of infection.https://www.mdpi.com/2414-6366/8/12/514SARS-CoV-2SARS-CoV-2 gene/sdiagnostic testingRT-PCRantigenantibody |
| spellingShingle | Natasha Samsunder Nikita Devnarain Aida Sivro Ayesha B. M. Kharsany The Performance of Diagnostic Tests for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the South African Population: A Scoping Review Tropical Medicine and Infectious Disease SARS-CoV-2 SARS-CoV-2 gene/s diagnostic testing RT-PCR antigen antibody |
| title | The Performance of Diagnostic Tests for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the South African Population: A Scoping Review |
| title_full | The Performance of Diagnostic Tests for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the South African Population: A Scoping Review |
| title_fullStr | The Performance of Diagnostic Tests for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the South African Population: A Scoping Review |
| title_full_unstemmed | The Performance of Diagnostic Tests for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the South African Population: A Scoping Review |
| title_short | The Performance of Diagnostic Tests for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the South African Population: A Scoping Review |
| title_sort | performance of diagnostic tests for severe acute respiratory syndrome coronavirus 2 sars cov 2 in the south african population a scoping review |
| topic | SARS-CoV-2 SARS-CoV-2 gene/s diagnostic testing RT-PCR antigen antibody |
| url | https://www.mdpi.com/2414-6366/8/12/514 |
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