The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research
DJ-1 (also known as PARK7) is a multifunctional enzyme in human beings that is highly conserved and that has also been discovered in diverse species (ranging from prokaryotes to eukaryotes). Its complex enzymatic and non-enzymatic activities (such as anti-oxidation, anti-glycation, and protein quali...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7409 |
| _version_ | 1797605091101900800 |
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| author | Mo E. Sun Qingfei Zheng |
| author_facet | Mo E. Sun Qingfei Zheng |
| author_sort | Mo E. Sun |
| collection | DOAJ |
| description | DJ-1 (also known as PARK7) is a multifunctional enzyme in human beings that is highly conserved and that has also been discovered in diverse species (ranging from prokaryotes to eukaryotes). Its complex enzymatic and non-enzymatic activities (such as anti-oxidation, anti-glycation, and protein quality control), as well as its role as a transcriptional coactivator, enable DJ-1 to serve as an essential regulator in multiple cellular processes (e.g., epigenetic regulations) and make it a promising therapeutic target for diverse diseases (especially cancer and Parkinson’s disease). Due to its nature as a Swiss army knife enzyme with various functions, DJ-1 has attracted a large amount of research interest, from different perspectives. In this review, we give a brief summary of the recent advances with respect to DJ-1 research in biomedicine and psychology, as well as the progress made in attempts to develop DJ-1 into a druggable target for therapy. |
| first_indexed | 2024-03-11T04:56:14Z |
| format | Article |
| id | doaj.art-88613cdc5aab48dfae44c948ada8b71c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:56:14Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-88613cdc5aab48dfae44c948ada8b71c2023-11-17T19:39:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248740910.3390/ijms24087409The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological ResearchMo E. Sun0Qingfei Zheng1Department of Psychology, Duquesne University, Pittsburgh, PA 15282, USADepartment of Radiation Oncology, College of Medicine, The Ohio State University, Columbus, OH 43210, USADJ-1 (also known as PARK7) is a multifunctional enzyme in human beings that is highly conserved and that has also been discovered in diverse species (ranging from prokaryotes to eukaryotes). Its complex enzymatic and non-enzymatic activities (such as anti-oxidation, anti-glycation, and protein quality control), as well as its role as a transcriptional coactivator, enable DJ-1 to serve as an essential regulator in multiple cellular processes (e.g., epigenetic regulations) and make it a promising therapeutic target for diverse diseases (especially cancer and Parkinson’s disease). Due to its nature as a Swiss army knife enzyme with various functions, DJ-1 has attracted a large amount of research interest, from different perspectives. In this review, we give a brief summary of the recent advances with respect to DJ-1 research in biomedicine and psychology, as well as the progress made in attempts to develop DJ-1 into a druggable target for therapy.https://www.mdpi.com/1422-0067/24/8/7409DJ-1/PARK7multifunctional enzymecancerpsychologytherapeutic target |
| spellingShingle | Mo E. Sun Qingfei Zheng The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research International Journal of Molecular Sciences DJ-1/PARK7 multifunctional enzyme cancer psychology therapeutic target |
| title | The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research |
| title_full | The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research |
| title_fullStr | The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research |
| title_full_unstemmed | The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research |
| title_short | The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research |
| title_sort | tale of dj 1 park7 a swiss army knife in biomedical and psychological research |
| topic | DJ-1/PARK7 multifunctional enzyme cancer psychology therapeutic target |
| url | https://www.mdpi.com/1422-0067/24/8/7409 |
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