TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells

TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells

Cellular responses to the loss of genomic stability are well-established, while how mammalian cells respond to chromatin destabilization is largely unknown. We previously found that DNA demethylation on p53-deficient background leads to transcription of repetitive heterochromatin elements, followed...

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Bibliographic Details
Main Authors: Katerina Leonova, Alfiya Safina, Elimelech Nesher, Poorva Sandlesh, Rachel Pratt, Catherine Burkhart, Brittany Lipchick, Ilya Gitlin, Costakis Frangou, Igor Koman, Jianmin Wang, Kirill Kirsanov, Marianna G Yakubovskaya, Andrei V Gudkov, Katerina Gurova
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
chromatin
TRAIN
CBL0137
nucleosome
curaxin
interferons
Online Access:https://elifesciences.org/articles/30842

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