Modelling acute myeloid leukaemia in a continuum of differentiation states

Modelling acute myeloid leukaemia in a continuum of differentiation states

Here we present a mathematical model of movement in an abstract space representing states of cellular differentiation. We motivate this work with recent examples that demonstrate a continuum of cellular differentiation using single-cell RNA-sequencing data to characterize cellular states in a high-d...

Full description

Bibliographic Details
Main Authors: H. Cho, K. Ayers, L. de Pills, Y.-H. Kuo, J. Park, A. Radunskaya, R. C. Rockne
Format: Article
Language:English
Published: Intercollegiate Biomathematics Alliance 2018-06-01
Series:Letters in Biomathematics
Subjects:
Diffusion mapping
haematopoiesis
single-cell RNA-sequencing
developmental trajectories
nonlinear dimension reduction
cellular differentiation
acute myeloid leukaemia
differentiation continuum
Online Access:http://dx.doi.org/10.1080/23737867.2018.1472532

Similar Items

Similar Items