Fatty acid modulation of voltage- and ligand-gated ion channel function
Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the envir...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-11-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00573/full |
| _version_ | 1819212529378787328 |
|---|---|
| author | Silvia S. Antollini Silvia S. Antollini Francisco J Barrantes |
| author_facet | Silvia S. Antollini Silvia S. Antollini Francisco J Barrantes |
| author_sort | Silvia S. Antollini |
| collection | DOAJ |
| description | Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. FFA are continuously being produced and degraded, and a feedback regulatory function has been attributed to their turnover. The massive increase observed under some pathological conditions, especially in brain, has been interpreted as a protective mechanism possibly operative on ion channels, which in some cases is of stimulatory nature and in other cases inhibitory. Here we discuss the correlation between the structure of FFA and their ability to modulate protein function, evaluating the influence of saturation/unsaturation, number of double bonds, and cis versus trans isomerism. We further focus on the mechanisms of FFA modulation operating on voltage-gated and ligand-gated ion channel function, contrasting the still conflicting evidence on direct versus indirect mechanisms of action. |
| first_indexed | 2024-12-23T06:44:25Z |
| format | Article |
| id | doaj.art-8864add6e0f4403ebcb603c3afda9b4a |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-23T06:44:25Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-8864add6e0f4403ebcb603c3afda9b4a2022-12-21T17:56:37ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2016-11-01710.3389/fphys.2016.00573229289Fatty acid modulation of voltage- and ligand-gated ion channel functionSilvia S. Antollini0Silvia S. Antollini1Francisco J Barrantes2Instituto de Investigaciones Bioquímicas de Bahía Blanca (CONICET-UNS)Universidad Nacional del SurPontifical Catholic University of Argentina (UCA)-National Scientific and Technical Research Council of Argentina (CONICET)Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. FFA are continuously being produced and degraded, and a feedback regulatory function has been attributed to their turnover. The massive increase observed under some pathological conditions, especially in brain, has been interpreted as a protective mechanism possibly operative on ion channels, which in some cases is of stimulatory nature and in other cases inhibitory. Here we discuss the correlation between the structure of FFA and their ability to modulate protein function, evaluating the influence of saturation/unsaturation, number of double bonds, and cis versus trans isomerism. We further focus on the mechanisms of FFA modulation operating on voltage-gated and ligand-gated ion channel function, contrasting the still conflicting evidence on direct versus indirect mechanisms of action.http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00573/fullFatty AcidsIon ChannelsPUFAFFAligand-gated channelVLCFA |
| spellingShingle | Silvia S. Antollini Silvia S. Antollini Francisco J Barrantes Fatty acid modulation of voltage- and ligand-gated ion channel function Frontiers in Physiology Fatty Acids Ion Channels PUFA FFA ligand-gated channel VLCFA |
| title | Fatty acid modulation of voltage- and ligand-gated ion channel function |
| title_full | Fatty acid modulation of voltage- and ligand-gated ion channel function |
| title_fullStr | Fatty acid modulation of voltage- and ligand-gated ion channel function |
| title_full_unstemmed | Fatty acid modulation of voltage- and ligand-gated ion channel function |
| title_short | Fatty acid modulation of voltage- and ligand-gated ion channel function |
| title_sort | fatty acid modulation of voltage and ligand gated ion channel function |
| topic | Fatty Acids Ion Channels PUFA FFA ligand-gated channel VLCFA |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00573/full |
| work_keys_str_mv | AT silviasantollini fattyacidmodulationofvoltageandligandgatedionchannelfunction AT silviasantollini fattyacidmodulationofvoltageandligandgatedionchannelfunction AT franciscojbarrantes fattyacidmodulationofvoltageandligandgatedionchannelfunction |