Childhood allergic bronchopulmonary aspergillosis
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disease caused by Aspergillus induced hypersensitivity. It usually occurs in immunocompetent but susceptible patients with bronchial asthma and cystic fibrosis. If ABPA goes undiagnosed and untreated, it may progress to bronchiectasis and...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
|
| Series: | Lung India |
| Subjects: | |
| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2018;volume=35;issue=6;spage=499;epage=507;aulast=Jat |
| _version_ | 1811301452892602368 |
|---|---|
| author | Kana Ram Jat Pankaj C Vaidya Joseph L Mathew Sunil Jondhale Meenu Singh |
| author_facet | Kana Ram Jat Pankaj C Vaidya Joseph L Mathew Sunil Jondhale Meenu Singh |
| author_sort | Kana Ram Jat |
| collection | DOAJ |
| description | Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disease caused by Aspergillus induced hypersensitivity. It usually occurs in immunocompetent but susceptible patients with bronchial asthma and cystic fibrosis. If ABPA goes undiagnosed and untreated, it may progress to bronchiectasis and/or pulmonary fibrosis with significant morbidity and mortality. ABPA is a well-recognized entity in adults; however, there is lack of literature in children. The aim of the present review is to summarize pathophysiology, diagnostic criteria, clinical features, and treatment of ABPA with emphasis on the pediatric population. A literature search was undertaken through PubMed till April 30, 2018, with keywords “ABPA or allergic bronchopulmonary aspergillosis” with limitation to “title.” The relevant published articles related to ABPA in pediatric population were included for the review. The ABPA is very well studied in adults. Recently, it is increasingly being recognized in children. There is lack of separate diagnostic criteria of ABPA for children. Although there are no trials regarding treatment of ABPA in children, steroids and itraconazole are the mainstay of therapy based on studies in adults and observational studies in children. Omalizumab is upcoming therapy, especially in refractory ABPA cases. There is a need to develop the pediatric-specific cutoffs for diagnostic criteria in ABPA. Well-designed trials are required to determine appropriate treatment regimen in children. |
| first_indexed | 2024-04-13T07:09:14Z |
| format | Article |
| id | doaj.art-88673832a1364a219a43eafe4177f7ec |
| institution | Directory Open Access Journal |
| issn | 0970-2113 0974-598X |
| language | English |
| last_indexed | 2024-04-13T07:09:14Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Lung India |
| spelling | doaj.art-88673832a1364a219a43eafe4177f7ec2022-12-22T02:56:55ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2018-01-0135649950710.4103/lungindia.lungindia_216_18Childhood allergic bronchopulmonary aspergillosisKana Ram JatPankaj C VaidyaJoseph L MathewSunil JondhaleMeenu SinghAllergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disease caused by Aspergillus induced hypersensitivity. It usually occurs in immunocompetent but susceptible patients with bronchial asthma and cystic fibrosis. If ABPA goes undiagnosed and untreated, it may progress to bronchiectasis and/or pulmonary fibrosis with significant morbidity and mortality. ABPA is a well-recognized entity in adults; however, there is lack of literature in children. The aim of the present review is to summarize pathophysiology, diagnostic criteria, clinical features, and treatment of ABPA with emphasis on the pediatric population. A literature search was undertaken through PubMed till April 30, 2018, with keywords “ABPA or allergic bronchopulmonary aspergillosis” with limitation to “title.” The relevant published articles related to ABPA in pediatric population were included for the review. The ABPA is very well studied in adults. Recently, it is increasingly being recognized in children. There is lack of separate diagnostic criteria of ABPA for children. Although there are no trials regarding treatment of ABPA in children, steroids and itraconazole are the mainstay of therapy based on studies in adults and observational studies in children. Omalizumab is upcoming therapy, especially in refractory ABPA cases. There is a need to develop the pediatric-specific cutoffs for diagnostic criteria in ABPA. Well-designed trials are required to determine appropriate treatment regimen in children.http://www.lungindia.com/article.asp?issn=0970-2113;year=2018;volume=35;issue=6;spage=499;epage=507;aulast=JatAllergic bronchopulmonary aspergillosischildrenitraconazoleomalizumabsteroids |
| spellingShingle | Kana Ram Jat Pankaj C Vaidya Joseph L Mathew Sunil Jondhale Meenu Singh Childhood allergic bronchopulmonary aspergillosis Lung India Allergic bronchopulmonary aspergillosis children itraconazole omalizumab steroids |
| title | Childhood allergic bronchopulmonary aspergillosis |
| title_full | Childhood allergic bronchopulmonary aspergillosis |
| title_fullStr | Childhood allergic bronchopulmonary aspergillosis |
| title_full_unstemmed | Childhood allergic bronchopulmonary aspergillosis |
| title_short | Childhood allergic bronchopulmonary aspergillosis |
| title_sort | childhood allergic bronchopulmonary aspergillosis |
| topic | Allergic bronchopulmonary aspergillosis children itraconazole omalizumab steroids |
| url | http://www.lungindia.com/article.asp?issn=0970-2113;year=2018;volume=35;issue=6;spage=499;epage=507;aulast=Jat |
| work_keys_str_mv | AT kanaramjat childhoodallergicbronchopulmonaryaspergillosis AT pankajcvaidya childhoodallergicbronchopulmonaryaspergillosis AT josephlmathew childhoodallergicbronchopulmonaryaspergillosis AT suniljondhale childhoodallergicbronchopulmonaryaspergillosis AT meenusingh childhoodallergicbronchopulmonaryaspergillosis |