Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study
Abstract Aim The clinical impact of abdominal aortic calcification (AAC) in patients who undergo hepatectomy for hepatocellular carcinoma (HCC) is unknown. Methods To evaluate the impact of AAC on clinical outcomes, we analyzed 203 patients who underwent hepatectomy for HCC between 2010 and 2013. Re...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Annals of Gastroenterological Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ags3.12508 |
| _version_ | 1798024679041007616 |
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| author | Yuki Imaoka Masahiro Ohira Koki Sato Kouki Imaoka Shintaro Kuroda Hiroyuki Tahara Tsuyoshi Kobayashi Kentaro Ide Yuka Tanaka Hideki Ohdan |
| author_facet | Yuki Imaoka Masahiro Ohira Koki Sato Kouki Imaoka Shintaro Kuroda Hiroyuki Tahara Tsuyoshi Kobayashi Kentaro Ide Yuka Tanaka Hideki Ohdan |
| author_sort | Yuki Imaoka |
| collection | DOAJ |
| description | Abstract Aim The clinical impact of abdominal aortic calcification (AAC) in patients who undergo hepatectomy for hepatocellular carcinoma (HCC) is unknown. Methods To evaluate the impact of AAC on clinical outcomes, we analyzed 203 patients who underwent hepatectomy for HCC between 2010 and 2013. Results Kaplan–Meier survival curve analysis showed significantly worse overall survival (OS) in the high AAC group than in the low AAC group. The recurrence‐free survival (RFS) was also significantly worse in the high AAC group. In the multivariate analysis, high AAC (hazard ratio [HR], 2.51; 95% confidence interval [CI], 1.24–5.09; P = .01) was an independent risk factor for poor OS after hepatectomy for HCC. High AAC was also an independent risk factor for poor RFS (HR, 1.69; 95% CI, 1.04–2.76; P = .04). Conclusions Abdominal aortic calcification had a strong relationship with poor OS and RFS after hepatectomy for HCC. We suggest that AAC had a relationship with smoking and diabetes; therefore, AAC could reflect a surrogate for older age, worse health status, and inflammatory score. |
| first_indexed | 2024-04-11T18:06:33Z |
| format | Article |
| id | doaj.art-88674a35f0a84460a86b58456f0d4aad |
| institution | Directory Open Access Journal |
| issn | 2475-0328 |
| language | English |
| last_indexed | 2024-04-11T18:06:33Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj.art-88674a35f0a84460a86b58456f0d4aad2022-12-22T04:10:18ZengWileyAnnals of Gastroenterological Surgery2475-03282022-01-016114915810.1002/ags3.12508Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort studyYuki Imaoka0Masahiro Ohira1Koki Sato2Kouki Imaoka3Shintaro Kuroda4Hiroyuki Tahara5Tsuyoshi Kobayashi6Kentaro Ide7Yuka Tanaka8Hideki Ohdan9Department of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanAbstract Aim The clinical impact of abdominal aortic calcification (AAC) in patients who undergo hepatectomy for hepatocellular carcinoma (HCC) is unknown. Methods To evaluate the impact of AAC on clinical outcomes, we analyzed 203 patients who underwent hepatectomy for HCC between 2010 and 2013. Results Kaplan–Meier survival curve analysis showed significantly worse overall survival (OS) in the high AAC group than in the low AAC group. The recurrence‐free survival (RFS) was also significantly worse in the high AAC group. In the multivariate analysis, high AAC (hazard ratio [HR], 2.51; 95% confidence interval [CI], 1.24–5.09; P = .01) was an independent risk factor for poor OS after hepatectomy for HCC. High AAC was also an independent risk factor for poor RFS (HR, 1.69; 95% CI, 1.04–2.76; P = .04). Conclusions Abdominal aortic calcification had a strong relationship with poor OS and RFS after hepatectomy for HCC. We suggest that AAC had a relationship with smoking and diabetes; therefore, AAC could reflect a surrogate for older age, worse health status, and inflammatory score.https://doi.org/10.1002/ags3.12508calcificationHCCprognosis |
| spellingShingle | Yuki Imaoka Masahiro Ohira Koki Sato Kouki Imaoka Shintaro Kuroda Hiroyuki Tahara Tsuyoshi Kobayashi Kentaro Ide Yuka Tanaka Hideki Ohdan Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study Annals of Gastroenterological Surgery calcification HCC prognosis |
| title | Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study |
| title_full | Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study |
| title_fullStr | Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study |
| title_full_unstemmed | Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study |
| title_short | Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study |
| title_sort | impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma a retrospective cohort study |
| topic | calcification HCC prognosis |
| url | https://doi.org/10.1002/ags3.12508 |
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