Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study
Abstract Background The relationship between fibrosis-4 (FIB-4) index and clinical outcomes in patients with acute kidney injury (AKI) is unclear. We aimed to investigate the association between FIB-4 index and all-cause mortality in critically ill patients with AKI. Methods We used data from the Mu...
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-021-02071-2 |
| _version_ | 1818969274080821248 |
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| author | Yi-Yi Shi Rui Zheng Jie-Jie Cai Zheng-Dong Fang Wen-Jing Chen Jing-Ye Pan Song-Zan Qian |
| author_facet | Yi-Yi Shi Rui Zheng Jie-Jie Cai Zheng-Dong Fang Wen-Jing Chen Jing-Ye Pan Song-Zan Qian |
| author_sort | Yi-Yi Shi |
| collection | DOAJ |
| description | Abstract Background The relationship between fibrosis-4 (FIB-4) index and clinical outcomes in patients with acute kidney injury (AKI) is unclear. We aimed to investigate the association between FIB-4 index and all-cause mortality in critically ill patients with AKI. Methods We used data from the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC-III) database (v1.4). The FIB-4 score was calculated using the existing formulas. logistic regression model, and Cox proportional hazards model were used to assessed the relationship between the FIB-4 index and in-hospital,28-day and 90-day mortality, respectively. Results A total of 3592 patients with AKI included in the data analysis. 395 (10.99%) patients died during hospitalization and 458 (12.74%) patients died in 28-day. During the 90-day follow-up, 893 (22.54%) patients were dead. An elevated FIB-4 value was significantly associated with increased in-hospital mortality when used as a continuous variable (odds ratio [OR] 1.183, 95% confidence interval [CI] 1.072–1.305, P = 0.002) and as a quartile variable (OR of Q2 to Q4 1.216–1.744, with Q1 as reference). FIB-4 was positively associated with 28-day mortality of AKI patients with hazard ratio (HR) of 1.097 (95% CI 1.008, 1.194) and 1.098 (95% 1.032, 1.167) for 90-day mortality, respectively. Conclusion This study demonstrated the FIB-4 index is associated with clinical outcomes in critically ill patients with acute kidney injury. |
| first_indexed | 2024-12-20T14:17:58Z |
| format | Article |
| id | doaj.art-8867c69eb95641c8b78a476aaf43bc5c |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-20T14:17:58Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-8867c69eb95641c8b78a476aaf43bc5c2022-12-21T19:38:00ZengBMCBMC Gastroenterology1471-230X2021-12-012111910.1186/s12876-021-02071-2Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort studyYi-Yi Shi0Rui Zheng1Jie-Jie Cai2Zheng-Dong Fang3Wen-Jing Chen4Jing-Ye Pan5Song-Zan Qian6Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical UniversitySchool of the First Clinical Medical Sciences, Wenzhou Medical UniversitySchool of the First Clinical Medical Sciences, Wenzhou Medical UniversityDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical UniversityAbstract Background The relationship between fibrosis-4 (FIB-4) index and clinical outcomes in patients with acute kidney injury (AKI) is unclear. We aimed to investigate the association between FIB-4 index and all-cause mortality in critically ill patients with AKI. Methods We used data from the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC-III) database (v1.4). The FIB-4 score was calculated using the existing formulas. logistic regression model, and Cox proportional hazards model were used to assessed the relationship between the FIB-4 index and in-hospital,28-day and 90-day mortality, respectively. Results A total of 3592 patients with AKI included in the data analysis. 395 (10.99%) patients died during hospitalization and 458 (12.74%) patients died in 28-day. During the 90-day follow-up, 893 (22.54%) patients were dead. An elevated FIB-4 value was significantly associated with increased in-hospital mortality when used as a continuous variable (odds ratio [OR] 1.183, 95% confidence interval [CI] 1.072–1.305, P = 0.002) and as a quartile variable (OR of Q2 to Q4 1.216–1.744, with Q1 as reference). FIB-4 was positively associated with 28-day mortality of AKI patients with hazard ratio (HR) of 1.097 (95% CI 1.008, 1.194) and 1.098 (95% 1.032, 1.167) for 90-day mortality, respectively. Conclusion This study demonstrated the FIB-4 index is associated with clinical outcomes in critically ill patients with acute kidney injury.https://doi.org/10.1186/s12876-021-02071-2Acute kidney injuryFibrosis-4 (FIB-4)Liver fibrosisMortality |
| spellingShingle | Yi-Yi Shi Rui Zheng Jie-Jie Cai Zheng-Dong Fang Wen-Jing Chen Jing-Ye Pan Song-Zan Qian Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study BMC Gastroenterology Acute kidney injury Fibrosis-4 (FIB-4) Liver fibrosis Mortality |
| title | Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study |
| title_full | Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study |
| title_fullStr | Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study |
| title_full_unstemmed | Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study |
| title_short | Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study |
| title_sort | association of fib 4 index and clinical outcomes in critically ill patients with acute kidney injury a cohort study |
| topic | Acute kidney injury Fibrosis-4 (FIB-4) Liver fibrosis Mortality |
| url | https://doi.org/10.1186/s12876-021-02071-2 |
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