Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer
Breast cancer (BC) is one of the most common type of cancer and an important contributor to female mortality. Several genes and epigenetic modifications are involved in the development and progression of BC. Research in phytochemistry, nutrigenomics, and nutrigenetics has provided strong evidence th...
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MDPI AG
2021-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/8/1176 |
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| author | Tanima Bhattacharya Soumam Dutta Rokeya Akter Md. Habibur Rahman Chenmala Karthika Hechanur Puttappa Nagaswarupa Hanabe Chowdappa Ananda Murthy Ovidiu Fratila Roxana Brata Simona Bungau |
| author_facet | Tanima Bhattacharya Soumam Dutta Rokeya Akter Md. Habibur Rahman Chenmala Karthika Hechanur Puttappa Nagaswarupa Hanabe Chowdappa Ananda Murthy Ovidiu Fratila Roxana Brata Simona Bungau |
| author_sort | Tanima Bhattacharya |
| collection | DOAJ |
| description | Breast cancer (BC) is one of the most common type of cancer and an important contributor to female mortality. Several genes and epigenetic modifications are involved in the development and progression of BC. Research in phytochemistry, nutrigenomics, and nutrigenetics has provided strong evidence that certain phytonutrients are able to modulate gene expression at transcriptional and post-transcriptional levels. Such phytonutrients may also be beneficial to prevent and treat BC. In this review, we will focus on the nutrigenomic effects of various phytochemicals including polyphenols, phytosterols, terpenoids, alkaloids, and other compounds from different sources. Overall, these phytonutrients are found to inhibit BC cell proliferation, differentiation, invasion, metastasis, angiogenesis, and induce apoptotic cell death by targeting various molecular pathways. They also alter epigenetic mechanisms and enhance the chemosensitivity and radiosensitivity of cancer cells. Such phytochemicals may be used for the effective management of BC patients in the clinical setting in the future. The present article aims to summarize the specific molecular pathways involved in the genetic effects of phytochemicals in BC. |
| first_indexed | 2024-03-10T08:58:33Z |
| format | Article |
| id | doaj.art-88680aaebac4466d9a2e8f2201cd4616 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T08:58:33Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
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| series | Biomolecules |
| spelling | doaj.art-88680aaebac4466d9a2e8f2201cd46162023-11-22T06:55:55ZengMDPI AGBiomolecules2218-273X2021-08-01118117610.3390/biom11081176Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast CancerTanima Bhattacharya0Soumam Dutta1Rokeya Akter2Md. Habibur Rahman3Chenmala Karthika4Hechanur Puttappa Nagaswarupa5Hanabe Chowdappa Ananda Murthy6Ovidiu Fratila7Roxana Brata8Simona Bungau9College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, ChinaFood and Nutrition Division, University of Calcutta, Calcutta 700027, IndiaDepartment of Pharmacy, Jagannath University, Sadarghat, Dhaka 1100, BangladeshDepartment of Global Medical Science, Yonsei University Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, KoreaDepartment of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty 643001, IndiaDepartment of Studies in Chemistry, Davangere University, Shivagangothri, Davangere 577007, IndiaDepartment of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Adama P.O. Box 1888, EthiopiaDepartment of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaDepartment of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, RomaniaBreast cancer (BC) is one of the most common type of cancer and an important contributor to female mortality. Several genes and epigenetic modifications are involved in the development and progression of BC. Research in phytochemistry, nutrigenomics, and nutrigenetics has provided strong evidence that certain phytonutrients are able to modulate gene expression at transcriptional and post-transcriptional levels. Such phytonutrients may also be beneficial to prevent and treat BC. In this review, we will focus on the nutrigenomic effects of various phytochemicals including polyphenols, phytosterols, terpenoids, alkaloids, and other compounds from different sources. Overall, these phytonutrients are found to inhibit BC cell proliferation, differentiation, invasion, metastasis, angiogenesis, and induce apoptotic cell death by targeting various molecular pathways. They also alter epigenetic mechanisms and enhance the chemosensitivity and radiosensitivity of cancer cells. Such phytochemicals may be used for the effective management of BC patients in the clinical setting in the future. The present article aims to summarize the specific molecular pathways involved in the genetic effects of phytochemicals in BC.https://www.mdpi.com/2218-273X/11/8/1176breast cancerphytonutrientschemosensitizerpolyphenolsnutrigenomicgene expression |
| spellingShingle | Tanima Bhattacharya Soumam Dutta Rokeya Akter Md. Habibur Rahman Chenmala Karthika Hechanur Puttappa Nagaswarupa Hanabe Chowdappa Ananda Murthy Ovidiu Fratila Roxana Brata Simona Bungau Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer Biomolecules breast cancer phytonutrients chemosensitizer polyphenols nutrigenomic gene expression |
| title | Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer |
| title_full | Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer |
| title_fullStr | Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer |
| title_full_unstemmed | Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer |
| title_short | Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer |
| title_sort | role of phytonutrients in nutrigenetics and nutrigenomics perspective in curing breast cancer |
| topic | breast cancer phytonutrients chemosensitizer polyphenols nutrigenomic gene expression |
| url | https://www.mdpi.com/2218-273X/11/8/1176 |
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