The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease

The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease

DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3' to 5' degradation and processing of both nuclear and cytoplasmic RNA species. Recently, aberrant expression of DIS3 has been found to be implicated in a range of different cancer...

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Bibliographic Details
Main Authors: Sophie R. Robinson, Antony W. Oliver, Timothy J. Chevassut, Sarah F. Newbury
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Biomolecules
Subjects:
DIS3
exoribonuclease
multiple myeloma
RNA stability
Online Access:http://www.mdpi.com/2218-273X/5/3/1515

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