Platelet-rich plasma is similar to platelet-rich plasma plus hyaluronic acid for the treatment of knee osteoarthritis at 2 years: a randomized controlled trial
Introduction: Autologous platelet-rich plasma (PRP) and hyaluronic acid (HA) are common treatments for knee osteoarthritis (OA). Several studies have demonstrated PRP as a safe and effective treatment for OA and, in some studies, produces a better outcome than HA. Objective: The primary objective of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Journal of Cartilage & Joint Preservation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667254523000343 |
| _version_ | 1797398431311855616 |
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| author | Eric A. Branch Joshua J. Cook Achraf Cohen Hillary Plummer Alireza Emami Jessica Truett Adam W. Anz |
| author_facet | Eric A. Branch Joshua J. Cook Achraf Cohen Hillary Plummer Alireza Emami Jessica Truett Adam W. Anz |
| author_sort | Eric A. Branch |
| collection | DOAJ |
| description | Introduction: Autologous platelet-rich plasma (PRP) and hyaluronic acid (HA) are common treatments for knee osteoarthritis (OA). Several studies have demonstrated PRP as a safe and effective treatment for OA and, in some studies, produces a better outcome than HA. Objective: The primary objective of this study was to determine if HA injected with PRP would improve the efficacy of treatment of symptomatic knee OA compared to PRP alone. We hypothesized that the addition of HA would improve the efficacy of (PRP). Methods: A total of 64 participants with Kellgren-Lawrence (KL) Grades 1 to 4 knee OA were randomized into 2 groups and scheduled to receive 3-injections. Group 1 [PRP] received injections of PRP. Group 2 [HA+PRP] received the same treatment, with an additional HA injection for the first 2 injections. Both groups were blindfolded for the first 2 injections. To evaluate the efficacy of the regimen, participants completed patient reported outcome measures (PROMs). PROMs were completed prior to injections and at 1, 3, 6, 12, 18, and 24 months after the final injection. Results: Participants in both groups felt pain consistent with standard-of-care HA injection regimens with no difference in perceived pain. No infections or complications were observed. All PROM scores demonstrated improvement over baseline from 1-24 months post injections. There were no statistically significant differences between the groups. Conclusions: For the treatment of OA, PRP alone or PRP concomitantly with HA performed similarly out to 24 months. PRP in combination with HA was not superior to PRP alone. |
| first_indexed | 2024-03-09T01:25:28Z |
| format | Article |
| id | doaj.art-8869d1ed1d1543dcb5ec6dc0bc3ceb4c |
| institution | Directory Open Access Journal |
| issn | 2667-2545 |
| language | English |
| last_indexed | 2024-03-09T01:25:28Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cartilage & Joint Preservation |
| spelling | doaj.art-8869d1ed1d1543dcb5ec6dc0bc3ceb4c2023-12-10T06:18:55ZengElsevierJournal of Cartilage & Joint Preservation2667-25452023-12-0134100129Platelet-rich plasma is similar to platelet-rich plasma plus hyaluronic acid for the treatment of knee osteoarthritis at 2 years: a randomized controlled trialEric A. Branch0Joshua J. Cook1Achraf Cohen2Hillary Plummer3Alireza Emami4Jessica Truett5Adam W. Anz6Andrews Institute Center for Regenerative Medicine, Department of Research, Andrews Research & Education Foundation, Gulf Breeze, FL, USAAndrews Institute Center for Regenerative Medicine, Department of Research, Andrews Research & Education Foundation, Gulf Breeze, FL, USADepartment of Mathematics and Statistics, University of West Florida, Pensacola, FL, USAAndrews Institute Center for Regenerative Medicine, Department of Research, Andrews Research & Education Foundation, Gulf Breeze, FL, USAAndrews Institute Center for Regenerative Medicine, Department of Research, Andrews Research & Education Foundation, Gulf Breeze, FL, USAAndrews Institute Center for Regenerative Medicine, Department of Research, Andrews Research & Education Foundation, Gulf Breeze, FL, USAAndrews Institute Center for Regenerative Medicine, Department of Research, Andrews Research & Education Foundation, Gulf Breeze, FL, USA; Adam W. Anz, Andrews Research & Education Foundation, 1020 Gulf Breeze Pkwy, Gulf Breeze, FL 32561.Introduction: Autologous platelet-rich plasma (PRP) and hyaluronic acid (HA) are common treatments for knee osteoarthritis (OA). Several studies have demonstrated PRP as a safe and effective treatment for OA and, in some studies, produces a better outcome than HA. Objective: The primary objective of this study was to determine if HA injected with PRP would improve the efficacy of treatment of symptomatic knee OA compared to PRP alone. We hypothesized that the addition of HA would improve the efficacy of (PRP). Methods: A total of 64 participants with Kellgren-Lawrence (KL) Grades 1 to 4 knee OA were randomized into 2 groups and scheduled to receive 3-injections. Group 1 [PRP] received injections of PRP. Group 2 [HA+PRP] received the same treatment, with an additional HA injection for the first 2 injections. Both groups were blindfolded for the first 2 injections. To evaluate the efficacy of the regimen, participants completed patient reported outcome measures (PROMs). PROMs were completed prior to injections and at 1, 3, 6, 12, 18, and 24 months after the final injection. Results: Participants in both groups felt pain consistent with standard-of-care HA injection regimens with no difference in perceived pain. No infections or complications were observed. All PROM scores demonstrated improvement over baseline from 1-24 months post injections. There were no statistically significant differences between the groups. Conclusions: For the treatment of OA, PRP alone or PRP concomitantly with HA performed similarly out to 24 months. PRP in combination with HA was not superior to PRP alone.http://www.sciencedirect.com/science/article/pii/S2667254523000343ChondrodegenerationHyaluronic acidInflammatory biomarkersKnee osteoarthritisPlatelet-rich plasmaViscosupplementation |
| spellingShingle | Eric A. Branch Joshua J. Cook Achraf Cohen Hillary Plummer Alireza Emami Jessica Truett Adam W. Anz Platelet-rich plasma is similar to platelet-rich plasma plus hyaluronic acid for the treatment of knee osteoarthritis at 2 years: a randomized controlled trial Journal of Cartilage & Joint Preservation Chondrodegeneration Hyaluronic acid Inflammatory biomarkers Knee osteoarthritis Platelet-rich plasma Viscosupplementation |
| title | Platelet-rich plasma is similar to platelet-rich plasma plus hyaluronic acid for the treatment of knee osteoarthritis at 2 years: a randomized controlled trial |
| title_full | Platelet-rich plasma is similar to platelet-rich plasma plus hyaluronic acid for the treatment of knee osteoarthritis at 2 years: a randomized controlled trial |
| title_fullStr | Platelet-rich plasma is similar to platelet-rich plasma plus hyaluronic acid for the treatment of knee osteoarthritis at 2 years: a randomized controlled trial |
| title_full_unstemmed | Platelet-rich plasma is similar to platelet-rich plasma plus hyaluronic acid for the treatment of knee osteoarthritis at 2 years: a randomized controlled trial |
| title_short | Platelet-rich plasma is similar to platelet-rich plasma plus hyaluronic acid for the treatment of knee osteoarthritis at 2 years: a randomized controlled trial |
| title_sort | platelet rich plasma is similar to platelet rich plasma plus hyaluronic acid for the treatment of knee osteoarthritis at 2 years a randomized controlled trial |
| topic | Chondrodegeneration Hyaluronic acid Inflammatory biomarkers Knee osteoarthritis Platelet-rich plasma Viscosupplementation |
| url | http://www.sciencedirect.com/science/article/pii/S2667254523000343 |
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