The Associations Between Sleep Architecture and Metabolic Parameters in Patients With Obstructive Sleep Apnea: A Hospital-Based Cohort Study
Background and Objectives: The associations between objective sleep architecture and metabolic parameters have been rarely studied in patients with obstructive sleep apnea (OSA). Here, we evaluated the associations between objective sleep measures derived via polysomnography (PSG) and metabolic para...
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| Format: | Article |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.606031/full |
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| author | Nana Feng Jundong Yang Huajun Xu Huajun Xu Huajun Xu Chujun Zhang Chujun Zhang Chujun Zhang Fan Wang Fan Wang Fan Wang Xiaolin Wu Meizhen Gu |
| author_facet | Nana Feng Jundong Yang Huajun Xu Huajun Xu Huajun Xu Chujun Zhang Chujun Zhang Chujun Zhang Fan Wang Fan Wang Fan Wang Xiaolin Wu Meizhen Gu |
| author_sort | Nana Feng |
| collection | DOAJ |
| description | Background and Objectives: The associations between objective sleep architecture and metabolic parameters have been rarely studied in patients with obstructive sleep apnea (OSA). Here, we evaluated the associations between objective sleep measures derived via polysomnography (PSG) and metabolic parameters.Methods: A total of 2,308 subjects with suspected OSA were included. We measured common metabolic parameters such as body mass index (BMI) and glucose, insulin, blood pressure, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels. All subjects underwent full-night PSG. PSG sleep parameters included total sleep time (TST), time spent in slow-wave sleep (SWS) and rapid eye movement (REM) sleep, sleep efficiency, and the microarousal index (MAI).Results: The TST correlated with the BMI, glucose level, and systolic blood pressure. The SWS/TST ratio correlated with BMI and glucose, TC, and TG levels. The REM/TST ratio correlated with BMI, glucose, insulin, and TG levels, and diastolic blood pressure. We found significant relationships between sleep efficiency and BMI, glucose levels, and TG levels. The MAI was significantly correlated with all metabolic parameters. After adjustment for age, gender, smoking status, alcohol use, apnea hypopnea index, and oxygen desaturation index (ODI), multiple linear regression analysis showed that the MAI was independently associated with glucose level, TC, HDL, and LDL. REM/TST ratio was positively associated with diastolic blood pressure but negatively associated with glucose metabolism.Conclusions: Though some independent correlation between sleep and metabolic parameters was confirmed, only weak associations were observed, suggesting a clinically negligible influence of sleep structure. Further prospective studies are warranted to confirm our findings. |
| first_indexed | 2024-12-16T15:12:11Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-16T15:12:11Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-886c0b8fc6d640cda72bc5d796b43c592022-12-21T22:26:55ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-02-011210.3389/fneur.2021.606031606031The Associations Between Sleep Architecture and Metabolic Parameters in Patients With Obstructive Sleep Apnea: A Hospital-Based Cohort StudyNana Feng0Jundong Yang1Huajun Xu2Huajun Xu3Huajun Xu4Chujun Zhang5Chujun Zhang6Chujun Zhang7Fan Wang8Fan Wang9Fan Wang10Xiaolin Wu11Meizhen Gu12Department of Respiratory and Critical Medicine, Shanghai Eighth People's Hospital Affiliated to Jiangsu University, Shanghai, ChinaDepartment of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of Otolaryngology Head and Neck Surgery and Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaOtolaryngological Institute of Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology Head and Neck Surgery and Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaOtolaryngological Institute of Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology Head and Neck Surgery and Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaOtolaryngological Institute of Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaCentral Laboratory of Shanghai Eighth People's Hospital Affiliated to Jiangsu University, Shanghai, ChinaDepartment of Otolaryngology-Head & Neck Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, ChinaBackground and Objectives: The associations between objective sleep architecture and metabolic parameters have been rarely studied in patients with obstructive sleep apnea (OSA). Here, we evaluated the associations between objective sleep measures derived via polysomnography (PSG) and metabolic parameters.Methods: A total of 2,308 subjects with suspected OSA were included. We measured common metabolic parameters such as body mass index (BMI) and glucose, insulin, blood pressure, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels. All subjects underwent full-night PSG. PSG sleep parameters included total sleep time (TST), time spent in slow-wave sleep (SWS) and rapid eye movement (REM) sleep, sleep efficiency, and the microarousal index (MAI).Results: The TST correlated with the BMI, glucose level, and systolic blood pressure. The SWS/TST ratio correlated with BMI and glucose, TC, and TG levels. The REM/TST ratio correlated with BMI, glucose, insulin, and TG levels, and diastolic blood pressure. We found significant relationships between sleep efficiency and BMI, glucose levels, and TG levels. The MAI was significantly correlated with all metabolic parameters. After adjustment for age, gender, smoking status, alcohol use, apnea hypopnea index, and oxygen desaturation index (ODI), multiple linear regression analysis showed that the MAI was independently associated with glucose level, TC, HDL, and LDL. REM/TST ratio was positively associated with diastolic blood pressure but negatively associated with glucose metabolism.Conclusions: Though some independent correlation between sleep and metabolic parameters was confirmed, only weak associations were observed, suggesting a clinically negligible influence of sleep structure. Further prospective studies are warranted to confirm our findings.https://www.frontiersin.org/articles/10.3389/fneur.2021.606031/fullobstructive sleep apneametabolismsleep architecturepolysomnographysleep apnea |
| spellingShingle | Nana Feng Jundong Yang Huajun Xu Huajun Xu Huajun Xu Chujun Zhang Chujun Zhang Chujun Zhang Fan Wang Fan Wang Fan Wang Xiaolin Wu Meizhen Gu The Associations Between Sleep Architecture and Metabolic Parameters in Patients With Obstructive Sleep Apnea: A Hospital-Based Cohort Study Frontiers in Neurology obstructive sleep apnea metabolism sleep architecture polysomnography sleep apnea |
| title | The Associations Between Sleep Architecture and Metabolic Parameters in Patients With Obstructive Sleep Apnea: A Hospital-Based Cohort Study |
| title_full | The Associations Between Sleep Architecture and Metabolic Parameters in Patients With Obstructive Sleep Apnea: A Hospital-Based Cohort Study |
| title_fullStr | The Associations Between Sleep Architecture and Metabolic Parameters in Patients With Obstructive Sleep Apnea: A Hospital-Based Cohort Study |
| title_full_unstemmed | The Associations Between Sleep Architecture and Metabolic Parameters in Patients With Obstructive Sleep Apnea: A Hospital-Based Cohort Study |
| title_short | The Associations Between Sleep Architecture and Metabolic Parameters in Patients With Obstructive Sleep Apnea: A Hospital-Based Cohort Study |
| title_sort | associations between sleep architecture and metabolic parameters in patients with obstructive sleep apnea a hospital based cohort study |
| topic | obstructive sleep apnea metabolism sleep architecture polysomnography sleep apnea |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.606031/full |
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