ATP inhibits the spontaneous contractility of atria in rats
ATP is a multifunctional nucleotide. In recent years, strong evidence has accumulated that ATP may participate in intercellular signaling, where ATP acts as a cotransmitter. ATP participation in the regulation of physiological functions in the organism is carried out through specific purinoreceptors...
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| Format: | Article |
| Language: | English |
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Kazan Federal University
2018-12-01
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| Series: | Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki |
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| Online Access: | https://kpfu.ru/atp-inhibits-the-spontaneous-contractility-of_382281.html |
| _version_ | 1797810860559695872 |
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| author | A.A. Zverev T.A. Anikina N.G. Iskakov N.V. Leonov T.L. Zefirov |
| author_facet | A.A. Zverev T.A. Anikina N.G. Iskakov N.V. Leonov T.L. Zefirov |
| author_sort | A.A. Zverev |
| collection | DOAJ |
| description | ATP is a multifunctional nucleotide. In recent years, strong evidence has accumulated that ATP may participate in intercellular signaling, where ATP acts as a cotransmitter. ATP participation in the regulation of physiological functions in the organism is carried out through specific purinoreceptors, which were found in many tissues of the organism, including the heart. The aim of our research was to study the role of ATP at different concentrations on the parameters of electrical activity and the contractility of the myocardium of the right atrium of rats with a preserved sinus node.
The experiments were performed on the myocardium of the right atrium of rats with spontaneous activity. Isometric reduction and electrical activity of the drugs were recorded.
ATP at the concentration of 10–8 M caused no significant changes in the parameters under study. ATP at the concentration of 10–7 M caused two-phase changes in the amplitude-time parameters of myocardial contractility and electrical activity of the right atrium myocardium. In the first minutes of the experiment, ATP caused an increase in the frequency and strength of myocardium contraction and the duration of the action potential at the level of 20, 50, and 90% repolarization. By the 15th minute, the studied parameters were restored. ATP at the concentration of 10–6 M caused a negative inotropic and chronotropic effect, through the activation of adenosine receptors. |
| first_indexed | 2024-03-13T07:14:02Z |
| format | Article |
| id | doaj.art-886cd6a6501643f9845aa2101e0ae294 |
| institution | Directory Open Access Journal |
| issn | 2542-064X 2500-218X |
| language | English |
| last_indexed | 2024-03-13T07:14:02Z |
| publishDate | 2018-12-01 |
| publisher | Kazan Federal University |
| record_format | Article |
| series | Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki |
| spelling | doaj.art-886cd6a6501643f9845aa2101e0ae2942023-06-05T11:54:51ZengKazan Federal UniversityUčënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki2542-064X2500-218X2018-12-011604558567ATP inhibits the spontaneous contractility of atria in ratsA.A. Zverev0T.A. Anikina1N.G. Iskakov2N.V. Leonov3T.L. Zefirov4Kazan Federal University, Kazan, 420008 RussiaKazan Federal University, Kazan, 420008 RussiaKazan Federal University, Kazan, 420008 RussiaKazan Federal University, Kazan, 420008 RussiaKazan Federal University, Kazan, 420008 RussiaATP is a multifunctional nucleotide. In recent years, strong evidence has accumulated that ATP may participate in intercellular signaling, where ATP acts as a cotransmitter. ATP participation in the regulation of physiological functions in the organism is carried out through specific purinoreceptors, which were found in many tissues of the organism, including the heart. The aim of our research was to study the role of ATP at different concentrations on the parameters of electrical activity and the contractility of the myocardium of the right atrium of rats with a preserved sinus node. The experiments were performed on the myocardium of the right atrium of rats with spontaneous activity. Isometric reduction and electrical activity of the drugs were recorded. ATP at the concentration of 10–8 M caused no significant changes in the parameters under study. ATP at the concentration of 10–7 M caused two-phase changes in the amplitude-time parameters of myocardial contractility and electrical activity of the right atrium myocardium. In the first minutes of the experiment, ATP caused an increase in the frequency and strength of myocardium contraction and the duration of the action potential at the level of 20, 50, and 90% repolarization. By the 15th minute, the studied parameters were restored. ATP at the concentration of 10–6 M caused a negative inotropic and chronotropic effect, through the activation of adenosine receptors.https://kpfu.ru/atp-inhibits-the-spontaneous-contractility-of_382281.htmlpurinoreceptorsatpaction potentialmyocardial contractility |
| spellingShingle | A.A. Zverev T.A. Anikina N.G. Iskakov N.V. Leonov T.L. Zefirov ATP inhibits the spontaneous contractility of atria in rats Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki purinoreceptors atp action potential myocardial contractility |
| title | ATP inhibits the spontaneous contractility of atria in rats |
| title_full | ATP inhibits the spontaneous contractility of atria in rats |
| title_fullStr | ATP inhibits the spontaneous contractility of atria in rats |
| title_full_unstemmed | ATP inhibits the spontaneous contractility of atria in rats |
| title_short | ATP inhibits the spontaneous contractility of atria in rats |
| title_sort | atp inhibits the spontaneous contractility of atria in rats |
| topic | purinoreceptors atp action potential myocardial contractility |
| url | https://kpfu.ru/atp-inhibits-the-spontaneous-contractility-of_382281.html |
| work_keys_str_mv | AT aazverev atpinhibitsthespontaneouscontractilityofatriainrats AT taanikina atpinhibitsthespontaneouscontractilityofatriainrats AT ngiskakov atpinhibitsthespontaneouscontractilityofatriainrats AT nvleonov atpinhibitsthespontaneouscontractilityofatriainrats AT tlzefirov atpinhibitsthespontaneouscontractilityofatriainrats |