Bioactive Glasses Enriched with Strontium or Zinc with Different Degrees of Structural Order as Components of Chitosan-Based Composite Scaffolds for Bone Tissue Engineering
The development of innovative biomaterials with improved integration with bone tissue and stimulating regeneration processes is necessary. Here, we evaluate the usefulness of bioactive glasses from the SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub>-CaO system enriched...
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MDPI AG
2023-10-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/19/3994 |
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| author | Lidia Ciołek Małgorzata Krok-Borkowicz Arkadiusz Gąsiński Monika Biernat Agnieszka Antosik Elżbieta Pamuła |
| author_facet | Lidia Ciołek Małgorzata Krok-Borkowicz Arkadiusz Gąsiński Monika Biernat Agnieszka Antosik Elżbieta Pamuła |
| author_sort | Lidia Ciołek |
| collection | DOAJ |
| description | The development of innovative biomaterials with improved integration with bone tissue and stimulating regeneration processes is necessary. Here, we evaluate the usefulness of bioactive glasses from the SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub>-CaO system enriched with 2 wt.% SrO or ZnO in the manufacturing of chitosan-based scaffolds. Bioglasses produced using the sol-gel method were subjected to thermal treatment in different regimes. Chitosan/bioglass composites were produced with a weight ratio. Bioglasses were evaluated via TG-DTA, FTIR, and SEM-EDS before and after incubation in simulated body fluid (SBF). The release of ions was tested. The cytocompatibility of the composites in contact with MG63 osteoblast-like cells was evaluated. The results showed that the presence of the crystalline phase decreased from 41.2–44.8% for nonmodified bioglasses to 24.2–24.3% for those modified with ZnO and 22.0–24.2% for those modified with SrO. The samples released Ca<sup>2+</sup>, Zn<sup>2+</sup>, and/or Sr<sup>2+</sup> ions and were bioactive according to the SBF test. The highest cytocompatibility was observed for the composites containing nonmodified bioglasses, followed by those enriched with SrO bioglasses. The least cytocompatible were the composites containing ZnO bioglasses that released the highest amount of Zn<sup>2+</sup> ions (0.58 ± 0.07 mL/g); however, those that released 0.38 ± 0.04 mL/g were characterised by acceptable cytocompatibility. The study confirmed that it is feasible to control the biological performance of chitosan/bioglass composites by adjusting the composition and heat treatment parameters of bioglasses. |
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| language | English |
| last_indexed | 2024-03-10T21:36:58Z |
| publishDate | 2023-10-01 |
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| series | Polymers |
| spelling | doaj.art-886e4d05df0a4ff89d0ce9394d80faf12023-11-19T14:57:24ZengMDPI AGPolymers2073-43602023-10-011519399410.3390/polym15193994Bioactive Glasses Enriched with Strontium or Zinc with Different Degrees of Structural Order as Components of Chitosan-Based Composite Scaffolds for Bone Tissue EngineeringLidia Ciołek0Małgorzata Krok-Borkowicz1Arkadiusz Gąsiński2Monika Biernat3Agnieszka Antosik4Elżbieta Pamuła5Biomaterials Research Group, Łukasiewicz Research Network—Institute of Ceramic and Building Materials, 31-983 Kraków, PolandDepartment of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Kraków, PolandCeramics Research Group, Łukasiewicz Research Network—Institute of Ceramic and Building Materials, 31-983 Kraków, PolandBiomaterials Research Group, Łukasiewicz Research Network—Institute of Ceramic and Building Materials, 31-983 Kraków, PolandCeramics Research Group, Łukasiewicz Research Network—Institute of Ceramic and Building Materials, 31-983 Kraków, PolandDepartment of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Kraków, PolandThe development of innovative biomaterials with improved integration with bone tissue and stimulating regeneration processes is necessary. Here, we evaluate the usefulness of bioactive glasses from the SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub>-CaO system enriched with 2 wt.% SrO or ZnO in the manufacturing of chitosan-based scaffolds. Bioglasses produced using the sol-gel method were subjected to thermal treatment in different regimes. Chitosan/bioglass composites were produced with a weight ratio. Bioglasses were evaluated via TG-DTA, FTIR, and SEM-EDS before and after incubation in simulated body fluid (SBF). The release of ions was tested. The cytocompatibility of the composites in contact with MG63 osteoblast-like cells was evaluated. The results showed that the presence of the crystalline phase decreased from 41.2–44.8% for nonmodified bioglasses to 24.2–24.3% for those modified with ZnO and 22.0–24.2% for those modified with SrO. The samples released Ca<sup>2+</sup>, Zn<sup>2+</sup>, and/or Sr<sup>2+</sup> ions and were bioactive according to the SBF test. The highest cytocompatibility was observed for the composites containing nonmodified bioglasses, followed by those enriched with SrO bioglasses. The least cytocompatible were the composites containing ZnO bioglasses that released the highest amount of Zn<sup>2+</sup> ions (0.58 ± 0.07 mL/g); however, those that released 0.38 ± 0.04 mL/g were characterised by acceptable cytocompatibility. The study confirmed that it is feasible to control the biological performance of chitosan/bioglass composites by adjusting the composition and heat treatment parameters of bioglasses.https://www.mdpi.com/2073-4360/15/19/3994bioglasschitosaninternal structure of glassbiodegradable composites |
| spellingShingle | Lidia Ciołek Małgorzata Krok-Borkowicz Arkadiusz Gąsiński Monika Biernat Agnieszka Antosik Elżbieta Pamuła Bioactive Glasses Enriched with Strontium or Zinc with Different Degrees of Structural Order as Components of Chitosan-Based Composite Scaffolds for Bone Tissue Engineering Polymers bioglass chitosan internal structure of glass biodegradable composites |
| title | Bioactive Glasses Enriched with Strontium or Zinc with Different Degrees of Structural Order as Components of Chitosan-Based Composite Scaffolds for Bone Tissue Engineering |
| title_full | Bioactive Glasses Enriched with Strontium or Zinc with Different Degrees of Structural Order as Components of Chitosan-Based Composite Scaffolds for Bone Tissue Engineering |
| title_fullStr | Bioactive Glasses Enriched with Strontium or Zinc with Different Degrees of Structural Order as Components of Chitosan-Based Composite Scaffolds for Bone Tissue Engineering |
| title_full_unstemmed | Bioactive Glasses Enriched with Strontium or Zinc with Different Degrees of Structural Order as Components of Chitosan-Based Composite Scaffolds for Bone Tissue Engineering |
| title_short | Bioactive Glasses Enriched with Strontium or Zinc with Different Degrees of Structural Order as Components of Chitosan-Based Composite Scaffolds for Bone Tissue Engineering |
| title_sort | bioactive glasses enriched with strontium or zinc with different degrees of structural order as components of chitosan based composite scaffolds for bone tissue engineering |
| topic | bioglass chitosan internal structure of glass biodegradable composites |
| url | https://www.mdpi.com/2073-4360/15/19/3994 |
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