Gd2O3/b‐TiO2 composite nanoprobes with ultra‐high photoconversion efficiency for MR image‐guided NIR‐II photothermal therapy
Abstract Photothermal therapy (PTT), as an important noninvasive and effective tumor treatment method, has been extensively developed into a powerful cancer therapeutic technique. Nevertheless, the low photothermal conversion efficiency and the limited tissue penetration of typical photothermal ther...
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| Format: | Article |
| Language: | English |
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Wiley
2022-12-01
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| Series: | Exploration |
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| Online Access: | https://doi.org/10.1002/EXP.20220014 |
| _version_ | 1811291458844491776 |
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| author | Jia Chen Tianxiang Chen Qianlan Fang Chunshu Pan Ozioma Udochukwu Akakuru Wenzhi Ren Jie Lin Aizhu Sheng Xuehua Ma Aiguo Wu |
| author_facet | Jia Chen Tianxiang Chen Qianlan Fang Chunshu Pan Ozioma Udochukwu Akakuru Wenzhi Ren Jie Lin Aizhu Sheng Xuehua Ma Aiguo Wu |
| author_sort | Jia Chen |
| collection | DOAJ |
| description | Abstract Photothermal therapy (PTT), as an important noninvasive and effective tumor treatment method, has been extensively developed into a powerful cancer therapeutic technique. Nevertheless, the low photothermal conversion efficiency and the limited tissue penetration of typical photothermal therapeutic agents in the first near‐infrared (NIR‐I) region (700–950 nm) are still the major barriers for further clinical application. Here, we proposed an organic/inorganic dual‐PTT agent of synergistic property driven by polydopamine‐modified black‐titanium dioxide (b‐TiO2@PDA) with excellent photoconversion efficiency in the second NIR (NIR‐II) region (1000–1500 nm). More specifically, the b‐TiO2 treated with sodium borohydride produced excessive oxygen vacancies resulting in oxygen vacancy band that narrowed the b‐TiO2 band gap, and the small band gap led to NIR‐II region wavelength (1064 nm) absorbance. Furthermore, the combination of defect energy level trapping carrier recombination heat generation and conjugate heat generation mechanism, significantly improved the photothermal performance of the PTT agent based on b‐TiO2. The photothermal properties characterization indicated that the proposed dual‐PTT agent possesses excellent photothermal performance and ultra‐high photoconversion efficiency of 64.9% under 1064 nm laser irradiation, which can completely kill esophageal squamous cells. Meanwhile, Gd2O3 nanoparticles, an excellent magnetic resonance imaging (MRI) agent, were introduced into the nanosystem with similar dotted core–shell structure to enable the nanosystem achieve real‐time MRI‐monitored cancer therapeutic performance. We believe that this integrated nanotherapeutic system can not only solve the application of PTT in the NIR‐II region, but also provide certain theoretical guidance for the clinical diagnosis and treatment of esophageal cancer. |
| first_indexed | 2024-04-13T04:29:44Z |
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| institution | Directory Open Access Journal |
| issn | 2766-8509 2766-2098 |
| language | English |
| last_indexed | 2024-04-13T04:29:44Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Exploration |
| spelling | doaj.art-8871515004814016ae697d8c9fa28aa82022-12-22T03:02:22ZengWileyExploration2766-85092766-20982022-12-0126n/an/a10.1002/EXP.20220014Gd2O3/b‐TiO2 composite nanoprobes with ultra‐high photoconversion efficiency for MR image‐guided NIR‐II photothermal therapyJia Chen0Tianxiang Chen1Qianlan Fang2Chunshu Pan3Ozioma Udochukwu Akakuru4Wenzhi Ren5Jie Lin6Aizhu Sheng7Xuehua Ma8Aiguo Wu9Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering, CAS Ningbo ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering, CAS Ningbo ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering, CAS Ningbo ChinaAdvanced Energy Science and Technology Guangdong Laboratory Huizhou ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering, CAS Ningbo ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering, CAS Ningbo ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering, CAS Ningbo ChinaDepartment of Radiology, Hwa Mei Hospital University of Chinese Academy of Sciences Ningbo ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering, CAS Ningbo ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering, CAS Ningbo ChinaAbstract Photothermal therapy (PTT), as an important noninvasive and effective tumor treatment method, has been extensively developed into a powerful cancer therapeutic technique. Nevertheless, the low photothermal conversion efficiency and the limited tissue penetration of typical photothermal therapeutic agents in the first near‐infrared (NIR‐I) region (700–950 nm) are still the major barriers for further clinical application. Here, we proposed an organic/inorganic dual‐PTT agent of synergistic property driven by polydopamine‐modified black‐titanium dioxide (b‐TiO2@PDA) with excellent photoconversion efficiency in the second NIR (NIR‐II) region (1000–1500 nm). More specifically, the b‐TiO2 treated with sodium borohydride produced excessive oxygen vacancies resulting in oxygen vacancy band that narrowed the b‐TiO2 band gap, and the small band gap led to NIR‐II region wavelength (1064 nm) absorbance. Furthermore, the combination of defect energy level trapping carrier recombination heat generation and conjugate heat generation mechanism, significantly improved the photothermal performance of the PTT agent based on b‐TiO2. The photothermal properties characterization indicated that the proposed dual‐PTT agent possesses excellent photothermal performance and ultra‐high photoconversion efficiency of 64.9% under 1064 nm laser irradiation, which can completely kill esophageal squamous cells. Meanwhile, Gd2O3 nanoparticles, an excellent magnetic resonance imaging (MRI) agent, were introduced into the nanosystem with similar dotted core–shell structure to enable the nanosystem achieve real‐time MRI‐monitored cancer therapeutic performance. We believe that this integrated nanotherapeutic system can not only solve the application of PTT in the NIR‐II region, but also provide certain theoretical guidance for the clinical diagnosis and treatment of esophageal cancer.https://doi.org/10.1002/EXP.20220014black‐titanium dioxidemagnetic resonance imagingphotothermal therapypolydopaminesecond near‐infrared |
| spellingShingle | Jia Chen Tianxiang Chen Qianlan Fang Chunshu Pan Ozioma Udochukwu Akakuru Wenzhi Ren Jie Lin Aizhu Sheng Xuehua Ma Aiguo Wu Gd2O3/b‐TiO2 composite nanoprobes with ultra‐high photoconversion efficiency for MR image‐guided NIR‐II photothermal therapy Exploration black‐titanium dioxide magnetic resonance imaging photothermal therapy polydopamine second near‐infrared |
| title | Gd2O3/b‐TiO2 composite nanoprobes with ultra‐high photoconversion efficiency for MR image‐guided NIR‐II photothermal therapy |
| title_full | Gd2O3/b‐TiO2 composite nanoprobes with ultra‐high photoconversion efficiency for MR image‐guided NIR‐II photothermal therapy |
| title_fullStr | Gd2O3/b‐TiO2 composite nanoprobes with ultra‐high photoconversion efficiency for MR image‐guided NIR‐II photothermal therapy |
| title_full_unstemmed | Gd2O3/b‐TiO2 composite nanoprobes with ultra‐high photoconversion efficiency for MR image‐guided NIR‐II photothermal therapy |
| title_short | Gd2O3/b‐TiO2 composite nanoprobes with ultra‐high photoconversion efficiency for MR image‐guided NIR‐II photothermal therapy |
| title_sort | gd2o3 b tio2 composite nanoprobes with ultra high photoconversion efficiency for mr image guided nir ii photothermal therapy |
| topic | black‐titanium dioxide magnetic resonance imaging photothermal therapy polydopamine second near‐infrared |
| url | https://doi.org/10.1002/EXP.20220014 |
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