MiRNA-Nanofiber, the Next Generation of Bioactive Scaffolds for Bone Regeneration: A Review
Scaffold-based bone tissue engineering has been introduced as an alternative treatment option for bone grafting due to limitations in the allograft. Not only physical conditions but also biological conditions such as gene expression significantly impact bone regeneration. Scaffolds in composition wi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/12/12/1472 |
| _version_ | 1797502456311054336 |
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| author | Davood Kharaghani Eben Bashir Kurniwan Muhammad Qamar Khan Yuji Yoshiko |
| author_facet | Davood Kharaghani Eben Bashir Kurniwan Muhammad Qamar Khan Yuji Yoshiko |
| author_sort | Davood Kharaghani |
| collection | DOAJ |
| description | Scaffold-based bone tissue engineering has been introduced as an alternative treatment option for bone grafting due to limitations in the allograft. Not only physical conditions but also biological conditions such as gene expression significantly impact bone regeneration. Scaffolds in composition with bioactive molecules such as miRNA mimics provide a platform to enhance migration, proliferation, and differentiation of osteoprogenitor cells for bone regeneration. Among scaffolds, fibrous structures showed significant advantages in promoting osteogenic differentiation and bone regeneration via delivering bioactive molecules over the past decade. Here, we reviewed the bone and bone fracture healing considerations for the impact of miRNAs on bone regeneration. We also examined the methods used to improve miRNA mimics uptake by cells, the fabrication of fibrous scaffolds, and the effective delivery of miRNA mimics using fibrous scaffold and their processes for bone development. Finally, we offer our view on the principal challenges of miRNA mimics delivery by nanofibers for bone tissue engineering. |
| first_indexed | 2024-03-10T03:33:21Z |
| format | Article |
| id | doaj.art-8871cd1c455f48a5ac3ec94769de6650 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T03:33:21Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-8871cd1c455f48a5ac3ec94769de66502023-11-23T09:35:51ZengMDPI AGMicromachines2072-666X2021-11-011212147210.3390/mi12121472MiRNA-Nanofiber, the Next Generation of Bioactive Scaffolds for Bone Regeneration: A ReviewDavood Kharaghani0Eben Bashir Kurniwan1Muhammad Qamar Khan2Yuji Yoshiko3Department of Calcified Tissue Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, JapanSchool of Dentistry, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, JapanNanotechnology Research Lab, Department of Textile and Clothing, National Textile University, Karachi Campus, Karachi 74900, PakistanDepartment of Calcified Tissue Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, JapanScaffold-based bone tissue engineering has been introduced as an alternative treatment option for bone grafting due to limitations in the allograft. Not only physical conditions but also biological conditions such as gene expression significantly impact bone regeneration. Scaffolds in composition with bioactive molecules such as miRNA mimics provide a platform to enhance migration, proliferation, and differentiation of osteoprogenitor cells for bone regeneration. Among scaffolds, fibrous structures showed significant advantages in promoting osteogenic differentiation and bone regeneration via delivering bioactive molecules over the past decade. Here, we reviewed the bone and bone fracture healing considerations for the impact of miRNAs on bone regeneration. We also examined the methods used to improve miRNA mimics uptake by cells, the fabrication of fibrous scaffolds, and the effective delivery of miRNA mimics using fibrous scaffold and their processes for bone development. Finally, we offer our view on the principal challenges of miRNA mimics delivery by nanofibers for bone tissue engineering.https://www.mdpi.com/2072-666X/12/12/1472bone regenerationbone formationnanofibermiRNA deliveryscaffold |
| spellingShingle | Davood Kharaghani Eben Bashir Kurniwan Muhammad Qamar Khan Yuji Yoshiko MiRNA-Nanofiber, the Next Generation of Bioactive Scaffolds for Bone Regeneration: A Review Micromachines bone regeneration bone formation nanofiber miRNA delivery scaffold |
| title | MiRNA-Nanofiber, the Next Generation of Bioactive Scaffolds for Bone Regeneration: A Review |
| title_full | MiRNA-Nanofiber, the Next Generation of Bioactive Scaffolds for Bone Regeneration: A Review |
| title_fullStr | MiRNA-Nanofiber, the Next Generation of Bioactive Scaffolds for Bone Regeneration: A Review |
| title_full_unstemmed | MiRNA-Nanofiber, the Next Generation of Bioactive Scaffolds for Bone Regeneration: A Review |
| title_short | MiRNA-Nanofiber, the Next Generation of Bioactive Scaffolds for Bone Regeneration: A Review |
| title_sort | mirna nanofiber the next generation of bioactive scaffolds for bone regeneration a review |
| topic | bone regeneration bone formation nanofiber miRNA delivery scaffold |
| url | https://www.mdpi.com/2072-666X/12/12/1472 |
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