Mapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis
Over 50 genetic human disorders are attributed to the irregular expansion of microsatellites. These expanded microsatellite sequences can experience bidirectional transcription, leading to new reading frames. Beyond the standard AUG initiation or adjacent start codons, they are translated into prote...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024051727 |
| _version_ | 1797213391178170368 |
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| author | Taiqi Zhao Suying Duan Jiaqi Li Honglin Zheng Chenyang Liu Hang Zhang Haiyang Luo Yuming Xu |
| author_facet | Taiqi Zhao Suying Duan Jiaqi Li Honglin Zheng Chenyang Liu Hang Zhang Haiyang Luo Yuming Xu |
| author_sort | Taiqi Zhao |
| collection | DOAJ |
| description | Over 50 genetic human disorders are attributed to the irregular expansion of microsatellites. These expanded microsatellite sequences can experience bidirectional transcription, leading to new reading frames. Beyond the standard AUG initiation or adjacent start codons, they are translated into proteins characterized by disease-causing amino acid repeats through repeat-associated non-AUG translation. Despite its significance, there's a discernible gap in comprehensive and objective articles on RAN translation. This study endeavors to evaluate and delineate the contemporary landscape and progress of RAN translation research via a bibliometric analysis. We sourced literature on RAN translation from the Web of Science Core Collection. Utilizing two bibliometric analysis tools, CiteSpace and VOSviewer, we gauged individual impacts and interactions by examining annual publications, journals, co-cited journals, countries/regions, institutions, authors, and co-cited authors. Following this, we assessed the co-occurrence and bursts of keywords and co-cited references to pinpoint research hotspots and trending in RAN translation. Between 2011 and 2022, 1317 authors across 359 institutions from 34 countries/regions contributed to 250 publications on RAN translation, spread across 118 academic journals. This article presents a systematic, objective, and comprehensive analysis of the current literature on RAN translation. Our findings emphasize that mechanisms related to C9orf72 ALS/FTD are pivotal topics in the realm of RAN translation, with cellular stress and the utilization of small molecule marking the trending research areas. |
| first_indexed | 2024-04-24T10:57:32Z |
| format | Article |
| id | doaj.art-8871df76e4dc4f1f937db0cabedbeb39 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T10:57:32Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-8871df76e4dc4f1f937db0cabedbeb392024-04-12T04:45:32ZengElsevierHeliyon2405-84402024-04-01108e29141Mapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysisTaiqi Zhao0Suying Duan1Jiaqi Li2Honglin Zheng3Chenyang Liu4Hang Zhang5Haiyang Luo6Yuming Xu7Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China; The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China; Institute of Neuroscience, Zhengzhou University, Zhengzhou, Henan, China; Corresponding author. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Jian-She East Road, Zhengzhou, Henan, 450000, China.Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China; Institute of Neuroscience, Zhengzhou University, Zhengzhou, Henan, China; Corresponding author. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Jian-She East Road, Zhengzhou, Henan, 450000, China.Over 50 genetic human disorders are attributed to the irregular expansion of microsatellites. These expanded microsatellite sequences can experience bidirectional transcription, leading to new reading frames. Beyond the standard AUG initiation or adjacent start codons, they are translated into proteins characterized by disease-causing amino acid repeats through repeat-associated non-AUG translation. Despite its significance, there's a discernible gap in comprehensive and objective articles on RAN translation. This study endeavors to evaluate and delineate the contemporary landscape and progress of RAN translation research via a bibliometric analysis. We sourced literature on RAN translation from the Web of Science Core Collection. Utilizing two bibliometric analysis tools, CiteSpace and VOSviewer, we gauged individual impacts and interactions by examining annual publications, journals, co-cited journals, countries/regions, institutions, authors, and co-cited authors. Following this, we assessed the co-occurrence and bursts of keywords and co-cited references to pinpoint research hotspots and trending in RAN translation. Between 2011 and 2022, 1317 authors across 359 institutions from 34 countries/regions contributed to 250 publications on RAN translation, spread across 118 academic journals. This article presents a systematic, objective, and comprehensive analysis of the current literature on RAN translation. Our findings emphasize that mechanisms related to C9orf72 ALS/FTD are pivotal topics in the realm of RAN translation, with cellular stress and the utilization of small molecule marking the trending research areas.http://www.sciencedirect.com/science/article/pii/S2405844024051727RAN translationC9orf72ALSFTDSmall moleculeCiteSpace |
| spellingShingle | Taiqi Zhao Suying Duan Jiaqi Li Honglin Zheng Chenyang Liu Hang Zhang Haiyang Luo Yuming Xu Mapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis Heliyon RAN translation C9orf72 ALS FTD Small molecule CiteSpace |
| title | Mapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis |
| title_full | Mapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis |
| title_fullStr | Mapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis |
| title_full_unstemmed | Mapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis |
| title_short | Mapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis |
| title_sort | mapping of repeat associated non aug ran translation knowledge a bibliometric analysis |
| topic | RAN translation C9orf72 ALS FTD Small molecule CiteSpace |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024051727 |
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