Effective Treatment With Afatinib of Lung Adenocarcinoma With Leptomeningeal Metastasis Harboring the Exon 18 p.G719A Mutation in the EGFR Gene Was Detected in Cerebrospinal Fluid: A Case Report

Effective Treatment With Afatinib of Lung Adenocarcinoma With Leptomeningeal Metastasis Harboring the Exon 18 p.G719A Mutation in the EGFR Gene Was Detected in Cerebrospinal Fluid: A Case Report

Background: In patients with lung adenocarcinoma and leptomeningeal metastases, it remains unknown whether non-classical mutations in the epidermal growth factor receptor (EGFR) gene can be detected in the cerebrospinal fluid (CSF) and how it may be used to design directed therapy.Methods: On April...

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Bibliographic Details
Main Authors: Chunhua Ma, Shuyuan Wang, Ning Mu, Jinduo Li, Mei Liu, Lin Li, Rong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
lung neoplasms
leptomeningeal metastasis
cerebrospinal fluid
non-classical mutations of EGFR
G719A mutation
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01635/full

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