The Role of NLRP3 Inflammasome in Lupus Nephritis
Lupus nephritis (LN) is the most frequent and severe of systemic lupus erythematosus (SLE) clinical manifestations and contributes to the increase of morbidity and mortality of patients due to chronic kidney disease. The NLRP3 (NLR pyrin domain containing 3) is a member of the NLR (NOD-like receptor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/22/12476 |
| _version_ | 1797510004006191104 |
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| author | Camila Barbosa Oliveira Camilla Albertina Dantas Lima Gisele Vajgel Paula Sandrin-Garcia |
| author_facet | Camila Barbosa Oliveira Camilla Albertina Dantas Lima Gisele Vajgel Paula Sandrin-Garcia |
| author_sort | Camila Barbosa Oliveira |
| collection | DOAJ |
| description | Lupus nephritis (LN) is the most frequent and severe of systemic lupus erythematosus (SLE) clinical manifestations and contributes to the increase of morbidity and mortality of patients due to chronic kidney disease. The NLRP3 (NLR pyrin domain containing 3) is a member of the NLR (NOD-like receptors), and its activation results in the production of pro-inflammatory cytokines, which can contribute to the pathogenesis of LN. In this review manuscript, we approach the relation between the NLRP3 inflammasome, SLE, and LN, highlighting the influence of genetic susceptibility of NLRP3 polymorphisms in the disease; the main functional studies using cellular and animal models of NLRP3 activation; and finally, some mechanisms of NLRP3 inhibition for the development of possible therapeutic drugs for LN. |
| first_indexed | 2024-03-10T05:25:46Z |
| format | Article |
| id | doaj.art-8874314f8c4444a39e4cbe2f64dfd88f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T05:25:46Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8874314f8c4444a39e4cbe2f64dfd88f2023-11-22T23:42:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122221247610.3390/ijms222212476The Role of NLRP3 Inflammasome in Lupus NephritisCamila Barbosa Oliveira0Camilla Albertina Dantas Lima1Gisele Vajgel2Paula Sandrin-Garcia3Division of Nephrology, Clinical Hospital, Federal University of Pernambuco, Recife 50670-901, BrazilLaboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Recife 50670-901, BrazilDivision of Nephrology, Clinical Hospital, Federal University of Pernambuco, Recife 50670-901, BrazilLaboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Recife 50670-901, BrazilLupus nephritis (LN) is the most frequent and severe of systemic lupus erythematosus (SLE) clinical manifestations and contributes to the increase of morbidity and mortality of patients due to chronic kidney disease. The NLRP3 (NLR pyrin domain containing 3) is a member of the NLR (NOD-like receptors), and its activation results in the production of pro-inflammatory cytokines, which can contribute to the pathogenesis of LN. In this review manuscript, we approach the relation between the NLRP3 inflammasome, SLE, and LN, highlighting the influence of genetic susceptibility of NLRP3 polymorphisms in the disease; the main functional studies using cellular and animal models of NLRP3 activation; and finally, some mechanisms of NLRP3 inhibition for the development of possible therapeutic drugs for LN.https://www.mdpi.com/1422-0067/22/22/12476inflammasomeNLRP3lupus nephritissystemic lupus erythematosus |
| spellingShingle | Camila Barbosa Oliveira Camilla Albertina Dantas Lima Gisele Vajgel Paula Sandrin-Garcia The Role of NLRP3 Inflammasome in Lupus Nephritis International Journal of Molecular Sciences inflammasome NLRP3 lupus nephritis systemic lupus erythematosus |
| title | The Role of NLRP3 Inflammasome in Lupus Nephritis |
| title_full | The Role of NLRP3 Inflammasome in Lupus Nephritis |
| title_fullStr | The Role of NLRP3 Inflammasome in Lupus Nephritis |
| title_full_unstemmed | The Role of NLRP3 Inflammasome in Lupus Nephritis |
| title_short | The Role of NLRP3 Inflammasome in Lupus Nephritis |
| title_sort | role of nlrp3 inflammasome in lupus nephritis |
| topic | inflammasome NLRP3 lupus nephritis systemic lupus erythematosus |
| url | https://www.mdpi.com/1422-0067/22/22/12476 |
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