bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials
This paper presents the R package bcrm for conducting and assessing Bayesian continual reassessment method (CRM) designs in Phase I dose-escalation trials. CRM designsare a class of adaptive design that select the dose to be given to the next recruited patient based on accumulating toxicity data f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Foundation for Open Access Statistics
2013-09-01
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| Series: | Journal of Statistical Software |
| Online Access: | http://www.jstatsoft.org/index.php/jss/article/view/2093 |
| _version_ | 1818902570340450304 |
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| author | Michael Sweeting Adrian Mander Tony Sabin |
| author_facet | Michael Sweeting Adrian Mander Tony Sabin |
| author_sort | Michael Sweeting |
| collection | DOAJ |
| description | This paper presents the R package bcrm for conducting and assessing Bayesian continual reassessment method (CRM) designs in Phase I dose-escalation trials. CRM designsare a class of adaptive design that select the dose to be given to the next recruited patient based on accumulating toxicity data from patients already recruited into the trial, often using Bayesian methodology. Despite the original CRM design being proposed in 1990, the methodology is still not widely implemented within oncology Phase I trials. The aim of this paper is to demonstrate, through example of the bcrm package, how a variety of possible designs can be easily implemented within the R statistical software, and how properties of the designs can be communicated to trial investigators using simple textual and graphical output obtained from the package. This in turn should facilitate an iterative process to allow a design to be chosen that is suitable to the needs of the investigator. Our bcrm package is the first to offer a large comprehensive choice of CRM designs, priors and escalation procedures, which can be easily compared and contrasted within the package through the assessment of operating characteristics. |
| first_indexed | 2024-12-19T20:37:45Z |
| format | Article |
| id | doaj.art-88744fe01ce94de5b70835aea019e3c5 |
| institution | Directory Open Access Journal |
| issn | 1548-7660 |
| language | English |
| last_indexed | 2024-12-19T20:37:45Z |
| publishDate | 2013-09-01 |
| publisher | Foundation for Open Access Statistics |
| record_format | Article |
| series | Journal of Statistical Software |
| spelling | doaj.art-88744fe01ce94de5b70835aea019e3c52022-12-21T20:06:29ZengFoundation for Open Access StatisticsJournal of Statistical Software1548-76602013-09-0154112610.18637/jss.v054.i13697bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding TrialsMichael SweetingAdrian ManderTony SabinThis paper presents the R package bcrm for conducting and assessing Bayesian continual reassessment method (CRM) designs in Phase I dose-escalation trials. CRM designsare a class of adaptive design that select the dose to be given to the next recruited patient based on accumulating toxicity data from patients already recruited into the trial, often using Bayesian methodology. Despite the original CRM design being proposed in 1990, the methodology is still not widely implemented within oncology Phase I trials. The aim of this paper is to demonstrate, through example of the bcrm package, how a variety of possible designs can be easily implemented within the R statistical software, and how properties of the designs can be communicated to trial investigators using simple textual and graphical output obtained from the package. This in turn should facilitate an iterative process to allow a design to be chosen that is suitable to the needs of the investigator. Our bcrm package is the first to offer a large comprehensive choice of CRM designs, priors and escalation procedures, which can be easily compared and contrasted within the package through the assessment of operating characteristics.http://www.jstatsoft.org/index.php/jss/article/view/2093 |
| spellingShingle | Michael Sweeting Adrian Mander Tony Sabin bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials Journal of Statistical Software |
| title | bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials |
| title_full | bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials |
| title_fullStr | bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials |
| title_full_unstemmed | bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials |
| title_short | bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials |
| title_sort | bcrm bayesian continual reassessment method designs for phase i dose finding trials |
| url | http://www.jstatsoft.org/index.php/jss/article/view/2093 |
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