Genome-wide studies in prostate cancer poised liquid biopsy as a molecular discovery tool
Liquid biopsy is emerging as an intriguing tool in clinical disease detection and monitoring. Compared to a standard tissue biopsy, performing a liquid biopsy incurs minimal invasiveness, captures comprehensive disease representation, and can be more sensitive at an early stage. Recent genome-wide l...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1185013/full |
| _version_ | 1797737520300032000 |
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| author | Nicholas Lo Housheng Hansen He Housheng Hansen He Sujun Chen Sujun Chen |
| author_facet | Nicholas Lo Housheng Hansen He Housheng Hansen He Sujun Chen Sujun Chen |
| author_sort | Nicholas Lo |
| collection | DOAJ |
| description | Liquid biopsy is emerging as an intriguing tool in clinical disease detection and monitoring. Compared to a standard tissue biopsy, performing a liquid biopsy incurs minimal invasiveness, captures comprehensive disease representation, and can be more sensitive at an early stage. Recent genome-wide liquid biopsy studies in prostate cancer analyzing plasma samples have provided insights into the genome and epigenome dynamics during disease progression. In-depth genomic sequencing can offer a comprehensive understanding of cancer evolution, enabling more accurate clinical decision-making. Furthermore, exploring beyond the DNA sequence itself provides opportunities to investigate the regulatory mechanisms underlying various disease phenotypes. Here, we summarize these advances and offer prospects for their future application. |
| first_indexed | 2024-03-12T13:29:34Z |
| format | Article |
| id | doaj.art-8875665cbc4d468686eaaf3d05243e3e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T13:29:34Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8875665cbc4d468686eaaf3d05243e3e2023-08-24T19:48:46ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-08-011310.3389/fonc.2023.11850131185013Genome-wide studies in prostate cancer poised liquid biopsy as a molecular discovery toolNicholas Lo0Housheng Hansen He1Housheng Hansen He2Sujun Chen3Sujun Chen4Princess Margaret Cancer Centre, University Health Network, Toronto, ON, CanadaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, CanadaDepartment of Medical Biophysics, University of Toronto, Toronto, ON, CanadaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, CanadaWest China School of Public Health, West China Fourth Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, ChinaLiquid biopsy is emerging as an intriguing tool in clinical disease detection and monitoring. Compared to a standard tissue biopsy, performing a liquid biopsy incurs minimal invasiveness, captures comprehensive disease representation, and can be more sensitive at an early stage. Recent genome-wide liquid biopsy studies in prostate cancer analyzing plasma samples have provided insights into the genome and epigenome dynamics during disease progression. In-depth genomic sequencing can offer a comprehensive understanding of cancer evolution, enabling more accurate clinical decision-making. Furthermore, exploring beyond the DNA sequence itself provides opportunities to investigate the regulatory mechanisms underlying various disease phenotypes. Here, we summarize these advances and offer prospects for their future application.https://www.frontiersin.org/articles/10.3389/fonc.2023.1185013/fullprostate cancerliquid biopsydeep genomic sequencinggenome-wide methylation analysisdisease progression |
| spellingShingle | Nicholas Lo Housheng Hansen He Housheng Hansen He Sujun Chen Sujun Chen Genome-wide studies in prostate cancer poised liquid biopsy as a molecular discovery tool Frontiers in Oncology prostate cancer liquid biopsy deep genomic sequencing genome-wide methylation analysis disease progression |
| title | Genome-wide studies in prostate cancer poised liquid biopsy as a molecular discovery tool |
| title_full | Genome-wide studies in prostate cancer poised liquid biopsy as a molecular discovery tool |
| title_fullStr | Genome-wide studies in prostate cancer poised liquid biopsy as a molecular discovery tool |
| title_full_unstemmed | Genome-wide studies in prostate cancer poised liquid biopsy as a molecular discovery tool |
| title_short | Genome-wide studies in prostate cancer poised liquid biopsy as a molecular discovery tool |
| title_sort | genome wide studies in prostate cancer poised liquid biopsy as a molecular discovery tool |
| topic | prostate cancer liquid biopsy deep genomic sequencing genome-wide methylation analysis disease progression |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1185013/full |
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