Extensive variation and strain-specificity in dengue virus susceptibility among African Aedes aegypti populations.
African populations of the mosquito Aedes aegypti are usually considered less susceptible to infection by human-pathogenic flaviviruses than globally invasive populations found outside Africa. Although this contrast has been well documented for Zika virus (ZIKV), it is unclear to what extent it is t...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-03-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011862&type=printable |
| _version_ | 1797200739322298368 |
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| author | Stéphanie Dabo Annabelle Henrion-Lacritick Alicia Lecuyer Davy Jiolle Christophe Paupy Diego Ayala Silvânia da Veiga Leal Athanase Badolo Anubis Vega-Rúa Massamba Sylla Jewelna Akorli Sampson Otoo Joel Lutomiah Rosemary Sang John-Paul Mutebi Maria-Carla Saleh Noah H Rose Carolyn S McBride Louis Lambrechts |
| author_facet | Stéphanie Dabo Annabelle Henrion-Lacritick Alicia Lecuyer Davy Jiolle Christophe Paupy Diego Ayala Silvânia da Veiga Leal Athanase Badolo Anubis Vega-Rúa Massamba Sylla Jewelna Akorli Sampson Otoo Joel Lutomiah Rosemary Sang John-Paul Mutebi Maria-Carla Saleh Noah H Rose Carolyn S McBride Louis Lambrechts |
| author_sort | Stéphanie Dabo |
| collection | DOAJ |
| description | African populations of the mosquito Aedes aegypti are usually considered less susceptible to infection by human-pathogenic flaviviruses than globally invasive populations found outside Africa. Although this contrast has been well documented for Zika virus (ZIKV), it is unclear to what extent it is true for dengue virus (DENV), the most prevalent flavivirus of humans. Addressing this question is complicated by substantial genetic diversity among DENV strains, most notably in the form of four genetic types (DENV1 to DENV4), that can lead to genetically specific interactions with mosquito populations. Here, we carried out a survey of DENV susceptibility using a panel of seven field-derived Ae. aegypti colonies from across the African range of the species and a colony from Guadeloupe, French West Indies as non-African reference. We found considerable variation in the ability of African Ae. aegypti populations to acquire and replicate a panel of six DENV strains spanning the four DENV types. Although African Ae. aegypti populations were generally less susceptible than the reference non-African population from Guadeloupe, in several instances some African populations were equally or more susceptible than the Guadeloupe population. Moreover, the relative level of susceptibility between African mosquito populations depended on the DENV strain, indicating genetically specific interactions. We conclude that unlike ZIKV susceptibility, there is no clear-cut dichotomy in DENV susceptibility between African and non-African Ae. aegypti. DENV susceptibility of African Ae. aegypti populations is highly heterogeneous and largely governed by the specific pairing of mosquito population and DENV strain. |
| first_indexed | 2024-04-24T07:36:26Z |
| format | Article |
| id | doaj.art-887770f33d474eec85dd8da7c51b7489 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-24T07:36:26Z |
| publishDate | 2024-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-887770f33d474eec85dd8da7c51b74892024-04-20T05:32:30ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352024-03-01183e001186210.1371/journal.pntd.0011862Extensive variation and strain-specificity in dengue virus susceptibility among African Aedes aegypti populations.Stéphanie DaboAnnabelle Henrion-LacritickAlicia LecuyerDavy JiolleChristophe PaupyDiego AyalaSilvânia da Veiga LealAthanase BadoloAnubis Vega-RúaMassamba SyllaJewelna AkorliSampson OtooJoel LutomiahRosemary SangJohn-Paul MutebiMaria-Carla SalehNoah H RoseCarolyn S McBrideLouis LambrechtsAfrican populations of the mosquito Aedes aegypti are usually considered less susceptible to infection by human-pathogenic flaviviruses than globally invasive populations found outside Africa. Although this contrast has been well documented for Zika virus (ZIKV), it is unclear to what extent it is true for dengue virus (DENV), the most prevalent flavivirus of humans. Addressing this question is complicated by substantial genetic diversity among DENV strains, most notably in the form of four genetic types (DENV1 to DENV4), that can lead to genetically specific interactions with mosquito populations. Here, we carried out a survey of DENV susceptibility using a panel of seven field-derived Ae. aegypti colonies from across the African range of the species and a colony from Guadeloupe, French West Indies as non-African reference. We found considerable variation in the ability of African Ae. aegypti populations to acquire and replicate a panel of six DENV strains spanning the four DENV types. Although African Ae. aegypti populations were generally less susceptible than the reference non-African population from Guadeloupe, in several instances some African populations were equally or more susceptible than the Guadeloupe population. Moreover, the relative level of susceptibility between African mosquito populations depended on the DENV strain, indicating genetically specific interactions. We conclude that unlike ZIKV susceptibility, there is no clear-cut dichotomy in DENV susceptibility between African and non-African Ae. aegypti. DENV susceptibility of African Ae. aegypti populations is highly heterogeneous and largely governed by the specific pairing of mosquito population and DENV strain.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011862&type=printable |
| spellingShingle | Stéphanie Dabo Annabelle Henrion-Lacritick Alicia Lecuyer Davy Jiolle Christophe Paupy Diego Ayala Silvânia da Veiga Leal Athanase Badolo Anubis Vega-Rúa Massamba Sylla Jewelna Akorli Sampson Otoo Joel Lutomiah Rosemary Sang John-Paul Mutebi Maria-Carla Saleh Noah H Rose Carolyn S McBride Louis Lambrechts Extensive variation and strain-specificity in dengue virus susceptibility among African Aedes aegypti populations. PLoS Neglected Tropical Diseases |
| title | Extensive variation and strain-specificity in dengue virus susceptibility among African Aedes aegypti populations. |
| title_full | Extensive variation and strain-specificity in dengue virus susceptibility among African Aedes aegypti populations. |
| title_fullStr | Extensive variation and strain-specificity in dengue virus susceptibility among African Aedes aegypti populations. |
| title_full_unstemmed | Extensive variation and strain-specificity in dengue virus susceptibility among African Aedes aegypti populations. |
| title_short | Extensive variation and strain-specificity in dengue virus susceptibility among African Aedes aegypti populations. |
| title_sort | extensive variation and strain specificity in dengue virus susceptibility among african aedes aegypti populations |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011862&type=printable |
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