Effects of mycophenolate sodium on mucociliary clearance using a bronchial section and anastomosis rodent model
OBJECTIVE: To study the effects of mycophenolate sodium on mucociliary clearance. INTRODUCTION: Mycophenolate is one of the most commonly used immunosuppressive drugs in lung transplantation. Although its pharmacokinetic properties are well defined, its side effects on mucociliary clearance have not...
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| Format: | Article |
| Language: | English |
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Elsevier España
2011-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000800024 |
| _version_ | 1818246751073599488 |
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| author | Viviane Ferreira Paes e Silva Rogerio Pazetti Sonia de Fatima Soto Mariana Moreira Quinhones Siqueira Aristides Tadeu Correia Fabio Biscegli Jatene Paulo Manuel Pego-Fernandes |
| author_facet | Viviane Ferreira Paes e Silva Rogerio Pazetti Sonia de Fatima Soto Mariana Moreira Quinhones Siqueira Aristides Tadeu Correia Fabio Biscegli Jatene Paulo Manuel Pego-Fernandes |
| author_sort | Viviane Ferreira Paes e Silva |
| collection | DOAJ |
| description | OBJECTIVE: To study the effects of mycophenolate sodium on mucociliary clearance. INTRODUCTION: Mycophenolate is one of the most commonly used immunosuppressive drugs in lung transplantation. Although its pharmacokinetic properties are well defined, its side effects on mucociliary clearance have not yet been studied. METHODS: Sixty rats were subjected to left bronchial section and anastomosis. The right bronchus was used as a control. After surgery, the rats were assigned to two groups based on whether they received saline solution (n = 30) or mycophenolate sodium (n = 30). After 7, 15, or 30 days of treatment, 10 animals from each group were sacrificed, and in vitro mucus transportability, in situ mucociliary transport velocity and ciliary beat frequency were measured. RESULTS: The analysis of mucus transportability revealed that neither mycophenolate nor bronchial section altered any transportability related property for up to 30 days of treatment after surgery (p>0.05). With regard to ciliary beat frequency, the operated left bronchi from the mycophenolate group showed a significant decrease on post-surgical day 30 (p = 0.003). In addition, we found a significant reduction in the in situ mucociliary transport velocity in the mycophenolate-treated group (p = 0.0001). DISCUSSION: These data add important information regarding mucociliary clearance dysfunction following mycophenolate therapy and suggest that mycophenolate might contribute to the high incidence of respiratory tract infections in lung transplant patients. Further studies are needed to investigate the combined action of mycophenolate with other immunosuppressive drugs and to establish methods to protect and recover mucociliary clearance, an important airway defense mechanism. |
| first_indexed | 2024-12-12T14:53:47Z |
| format | Article |
| id | doaj.art-8877d3ce9b9741e38303e5d32c79aa08 |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-12-12T14:53:47Z |
| publishDate | 2011-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-8877d3ce9b9741e38303e5d32c79aa082022-12-22T00:20:58ZengElsevier EspañaClinics1807-59321980-53222011-01-016681451145610.1590/S1807-59322011000800024Effects of mycophenolate sodium on mucociliary clearance using a bronchial section and anastomosis rodent modelViviane Ferreira Paes e SilvaRogerio PazettiSonia de Fatima SotoMariana Moreira Quinhones SiqueiraAristides Tadeu CorreiaFabio Biscegli JatenePaulo Manuel Pego-FernandesOBJECTIVE: To study the effects of mycophenolate sodium on mucociliary clearance. INTRODUCTION: Mycophenolate is one of the most commonly used immunosuppressive drugs in lung transplantation. Although its pharmacokinetic properties are well defined, its side effects on mucociliary clearance have not yet been studied. METHODS: Sixty rats were subjected to left bronchial section and anastomosis. The right bronchus was used as a control. After surgery, the rats were assigned to two groups based on whether they received saline solution (n = 30) or mycophenolate sodium (n = 30). After 7, 15, or 30 days of treatment, 10 animals from each group were sacrificed, and in vitro mucus transportability, in situ mucociliary transport velocity and ciliary beat frequency were measured. RESULTS: The analysis of mucus transportability revealed that neither mycophenolate nor bronchial section altered any transportability related property for up to 30 days of treatment after surgery (p>0.05). With regard to ciliary beat frequency, the operated left bronchi from the mycophenolate group showed a significant decrease on post-surgical day 30 (p = 0.003). In addition, we found a significant reduction in the in situ mucociliary transport velocity in the mycophenolate-treated group (p = 0.0001). DISCUSSION: These data add important information regarding mucociliary clearance dysfunction following mycophenolate therapy and suggest that mycophenolate might contribute to the high incidence of respiratory tract infections in lung transplant patients. Further studies are needed to investigate the combined action of mycophenolate with other immunosuppressive drugs and to establish methods to protect and recover mucociliary clearance, an important airway defense mechanism.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000800024Immunosuppressive AgentsLung TransplantationMucociliary ClearanceAnimals |
| spellingShingle | Viviane Ferreira Paes e Silva Rogerio Pazetti Sonia de Fatima Soto Mariana Moreira Quinhones Siqueira Aristides Tadeu Correia Fabio Biscegli Jatene Paulo Manuel Pego-Fernandes Effects of mycophenolate sodium on mucociliary clearance using a bronchial section and anastomosis rodent model Clinics Immunosuppressive Agents Lung Transplantation Mucociliary Clearance Animals |
| title | Effects of mycophenolate sodium on mucociliary clearance using a bronchial section and anastomosis rodent model |
| title_full | Effects of mycophenolate sodium on mucociliary clearance using a bronchial section and anastomosis rodent model |
| title_fullStr | Effects of mycophenolate sodium on mucociliary clearance using a bronchial section and anastomosis rodent model |
| title_full_unstemmed | Effects of mycophenolate sodium on mucociliary clearance using a bronchial section and anastomosis rodent model |
| title_short | Effects of mycophenolate sodium on mucociliary clearance using a bronchial section and anastomosis rodent model |
| title_sort | effects of mycophenolate sodium on mucociliary clearance using a bronchial section and anastomosis rodent model |
| topic | Immunosuppressive Agents Lung Transplantation Mucociliary Clearance Animals |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000800024 |
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