The Risk of Major Adverse Cardiovascular Events in Ankylosing Spondylitis Patients With a History of Acute Anterior Uveitis: A Nationwide, Population Based Cohort Study
BackgroundTo investigate the association between a history of acute anterior uveitis (AAU) and the risk of major adverse cardiovascular events (MACE) among patients with ankylosing spondylitis (AS).MethodsWe identified 38,691 newly diagnosed AS patients between 2003 and 2013 from the Taiwan National...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.884800/full |
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| author | Yi-Chiao Bai Yi-Chiao Bai Chin-Hsiu Liu Chin-Hsiu Liu Pui-Ying Leong Pui-Ying Leong Kuo-Lung Lai Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei |
| author_facet | Yi-Chiao Bai Yi-Chiao Bai Chin-Hsiu Liu Chin-Hsiu Liu Pui-Ying Leong Pui-Ying Leong Kuo-Lung Lai Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei |
| author_sort | Yi-Chiao Bai |
| collection | DOAJ |
| description | BackgroundTo investigate the association between a history of acute anterior uveitis (AAU) and the risk of major adverse cardiovascular events (MACE) among patients with ankylosing spondylitis (AS).MethodsWe identified 38,691 newly diagnosed AS patients between 2003 and 2013 from the Taiwan National Health Insurance Research Database. The exposure group was defined as people with uveitis diagnosis by ophthalmologist before AS diagnosis date. The incidence of MACE in patients with AS according to the International Classification of Diseases, Ninth Revision. We randomly selected a comparison group without a history of AAU at a 1:4 ratio matched by age, sex, and index year in relation to the risk of developing MACE. We used cox proportional hazard regression model to compare the risk of MACE between groups, shown as adjusted hazard ratios (aHRs) with 95% confidence intervals (CI). Further subgroup analysis and sensitivity tests were also performed.ResultsThere were 3,544 patients in the AAU group and 14,176 patients in the non-AAU group. The aHR of MACE for the AAU group was 0.79 (95% CI = 0.57–1.10) at a 1:4 ratio for age, sex and index year. Sensitivity analyses using various adjustment variables showed consistent results. Cox proportional hazard regression model demonstrated that use of non-steroidal anti-inflammatory drugs (NSAIDs) was associated with an increased risk of MACE in this cohort (HR = 3.44; 95% CI = 2.25–5.25).ConclusionThis cohort study showed that subjects with AAU was not associated with the risk of MACE among AS patients, compared to non-AAU controls. |
| first_indexed | 2024-04-13T20:59:08Z |
| format | Article |
| id | doaj.art-8878bf8229ae45b88a34276a45188606 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-13T20:59:08Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-8878bf8229ae45b88a34276a451886062022-12-22T02:30:13ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-07-01910.3389/fmed.2022.884800884800The Risk of Major Adverse Cardiovascular Events in Ankylosing Spondylitis Patients With a History of Acute Anterior Uveitis: A Nationwide, Population Based Cohort StudyYi-Chiao Bai0Yi-Chiao Bai1Chin-Hsiu Liu2Chin-Hsiu Liu3Pui-Ying Leong4Pui-Ying Leong5Kuo-Lung Lai6Hsin-Hua Chen7Hsin-Hua Chen8Hsin-Hua Chen9Hsin-Hua Chen10Hsin-Hua Chen11James Cheng-Chung Wei12James Cheng-Chung Wei13James Cheng-Chung Wei14Institute of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Optometry, Shu-Zen Junior College of Medicine and Management, Kaohsiung, TaiwanDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, TaiwanRheumatology and Immunology Center, China Medical University Hospital, Taichung, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, TaiwanDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, TaiwanDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, TaiwanSchool of Medicine, National Yang-Ming University, Taipei, TaiwanInstitute of Biomedical Science and Rong Hsing Research Centre for Translational Medicine, Chung Hsing University, Taichung, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, TaiwanDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan0Graduate Institute of Integrated Medicine, China Medical University, Taichung, TaiwanBackgroundTo investigate the association between a history of acute anterior uveitis (AAU) and the risk of major adverse cardiovascular events (MACE) among patients with ankylosing spondylitis (AS).MethodsWe identified 38,691 newly diagnosed AS patients between 2003 and 2013 from the Taiwan National Health Insurance Research Database. The exposure group was defined as people with uveitis diagnosis by ophthalmologist before AS diagnosis date. The incidence of MACE in patients with AS according to the International Classification of Diseases, Ninth Revision. We randomly selected a comparison group without a history of AAU at a 1:4 ratio matched by age, sex, and index year in relation to the risk of developing MACE. We used cox proportional hazard regression model to compare the risk of MACE between groups, shown as adjusted hazard ratios (aHRs) with 95% confidence intervals (CI). Further subgroup analysis and sensitivity tests were also performed.ResultsThere were 3,544 patients in the AAU group and 14,176 patients in the non-AAU group. The aHR of MACE for the AAU group was 0.79 (95% CI = 0.57–1.10) at a 1:4 ratio for age, sex and index year. Sensitivity analyses using various adjustment variables showed consistent results. Cox proportional hazard regression model demonstrated that use of non-steroidal anti-inflammatory drugs (NSAIDs) was associated with an increased risk of MACE in this cohort (HR = 3.44; 95% CI = 2.25–5.25).ConclusionThis cohort study showed that subjects with AAU was not associated with the risk of MACE among AS patients, compared to non-AAU controls.https://www.frontiersin.org/articles/10.3389/fmed.2022.884800/fullankylosing spondylitis (AS)acute anterior uveitis (AAU)cohort studymajor adverse cardiovascular events (MACE)autoimmune disease |
| spellingShingle | Yi-Chiao Bai Yi-Chiao Bai Chin-Hsiu Liu Chin-Hsiu Liu Pui-Ying Leong Pui-Ying Leong Kuo-Lung Lai Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei The Risk of Major Adverse Cardiovascular Events in Ankylosing Spondylitis Patients With a History of Acute Anterior Uveitis: A Nationwide, Population Based Cohort Study Frontiers in Medicine ankylosing spondylitis (AS) acute anterior uveitis (AAU) cohort study major adverse cardiovascular events (MACE) autoimmune disease |
| title | The Risk of Major Adverse Cardiovascular Events in Ankylosing Spondylitis Patients With a History of Acute Anterior Uveitis: A Nationwide, Population Based Cohort Study |
| title_full | The Risk of Major Adverse Cardiovascular Events in Ankylosing Spondylitis Patients With a History of Acute Anterior Uveitis: A Nationwide, Population Based Cohort Study |
| title_fullStr | The Risk of Major Adverse Cardiovascular Events in Ankylosing Spondylitis Patients With a History of Acute Anterior Uveitis: A Nationwide, Population Based Cohort Study |
| title_full_unstemmed | The Risk of Major Adverse Cardiovascular Events in Ankylosing Spondylitis Patients With a History of Acute Anterior Uveitis: A Nationwide, Population Based Cohort Study |
| title_short | The Risk of Major Adverse Cardiovascular Events in Ankylosing Spondylitis Patients With a History of Acute Anterior Uveitis: A Nationwide, Population Based Cohort Study |
| title_sort | risk of major adverse cardiovascular events in ankylosing spondylitis patients with a history of acute anterior uveitis a nationwide population based cohort study |
| topic | ankylosing spondylitis (AS) acute anterior uveitis (AAU) cohort study major adverse cardiovascular events (MACE) autoimmune disease |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.884800/full |
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