Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice

Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice

Shank2 is an abundant postsynaptic scaffolding protein implicated in neurodevelopmental and psychiatric disorders, including autism spectrum disorders (ASD). Deletion of Shank2 in mice has been shown to induce social deficits, repetitive behaviors, and hyperactivity, but the identity of the cell typ...

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Bibliographic Details
Main Authors: Seungjoon Lee, Eunee Lee, Ryunhee Kim, Jihye Kim, Suho Lee, Haram Park, Esther Yang, Hyun Kim, Eunjoon Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
autism spectrum disorder
Shank2
parvalbumin
GABAergic
social interaction
self-grooming
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00209/full

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