Exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, Brazil
BackgroundPyrethroids are commonly used insecticides in Brazil. Gestational and early childhood exposure to pyrethroids has been linked to adverse health effects, including neurodevelopmental delays, behavioral issues, and endocrine disruption. This study evaluated the exposure of pregnant women and...
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| Format: | Article |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1274724/full |
| _version_ | 1797390956579782656 |
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| author | Amanda Friaes Martins Aline Souza Espindola Santos Josino Costa Moreira Volney de Magalhaes Câmara Carmen Ildes Rodrigues Froes Asmus Ana Cristina Simoes Rosa Paolo Vineis Armando Meyer |
| author_facet | Amanda Friaes Martins Aline Souza Espindola Santos Josino Costa Moreira Volney de Magalhaes Câmara Carmen Ildes Rodrigues Froes Asmus Ana Cristina Simoes Rosa Paolo Vineis Armando Meyer |
| author_sort | Amanda Friaes Martins |
| collection | DOAJ |
| description | BackgroundPyrethroids are commonly used insecticides in Brazil. Gestational and early childhood exposure to pyrethroids has been linked to adverse health effects, including neurodevelopmental delays, behavioral issues, and endocrine disruption. This study evaluated the exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, Brazil.MethodsCreatinine-adjusted levels of the pyrethroid metabolites 3-phenoxy benzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzyl acid (4-FPBA) were measured in the urine of 142 pregnant women and their children at birth and in the first, third, and 6th months of life.ResultsThe geometric mean (GM) and 95% confidence interval (95% CI) of 3-PBA and 4-FPBA urinary concentrations in pregnant women were 0.50 (0.37–0.67) and 0.37 (0.05–2.90) ng/mg, detected in 47.2 and 10.6%, respectively. Urinary concentrations of 3-PBA in the children were 0.18 (0.15–0.23) ng/mg at birth, 0.36 (0.08–1.56) ng/mg at 1-month-old, 0.68 (0.36–1.27) ng/mg at 3-month-old, and 1.36 (0.77–2.42) ng/mg at 6-month-old, and the detection rates were respectively 10.8, 9.4, 20.9, and 20.7%.DiscussionThis study is one of the few that has evaluated the urinary concentrations of pyrethroids in newborns and children in their 1st year of life. The results of this study show that children's exposure to pyrethroids significantly increases after birth. |
| first_indexed | 2024-03-08T23:24:54Z |
| format | Article |
| id | doaj.art-8879289dd2b844a881d6250f2eaed163 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-08T23:24:54Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj.art-8879289dd2b844a881d6250f2eaed1632023-12-14T17:57:13ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-12-011110.3389/fpubh.2023.12747241274724Exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, BrazilAmanda Friaes Martins0Aline Souza Espindola Santos1Josino Costa Moreira2Volney de Magalhaes Câmara3Carmen Ildes Rodrigues Froes Asmus4Ana Cristina Simoes Rosa5Paolo Vineis6Armando Meyer7Public Health Program, Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilOccupational and Environmental Health Branch, Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilOccupational and Environmental Health Branch, Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilOccupational and Environmental Health Branch, Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilSchool of Medicine, Maternity School Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilCenter for Studies of Human Ecology and Worker's Health, National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United KingdomOccupational and Environmental Health Branch, Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilBackgroundPyrethroids are commonly used insecticides in Brazil. Gestational and early childhood exposure to pyrethroids has been linked to adverse health effects, including neurodevelopmental delays, behavioral issues, and endocrine disruption. This study evaluated the exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, Brazil.MethodsCreatinine-adjusted levels of the pyrethroid metabolites 3-phenoxy benzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzyl acid (4-FPBA) were measured in the urine of 142 pregnant women and their children at birth and in the first, third, and 6th months of life.ResultsThe geometric mean (GM) and 95% confidence interval (95% CI) of 3-PBA and 4-FPBA urinary concentrations in pregnant women were 0.50 (0.37–0.67) and 0.37 (0.05–2.90) ng/mg, detected in 47.2 and 10.6%, respectively. Urinary concentrations of 3-PBA in the children were 0.18 (0.15–0.23) ng/mg at birth, 0.36 (0.08–1.56) ng/mg at 1-month-old, 0.68 (0.36–1.27) ng/mg at 3-month-old, and 1.36 (0.77–2.42) ng/mg at 6-month-old, and the detection rates were respectively 10.8, 9.4, 20.9, and 20.7%.DiscussionThis study is one of the few that has evaluated the urinary concentrations of pyrethroids in newborns and children in their 1st year of life. The results of this study show that children's exposure to pyrethroids significantly increases after birth.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1274724/fullpyrethroidspregnant womenchildrenRio de JaneiroBrazil |
| spellingShingle | Amanda Friaes Martins Aline Souza Espindola Santos Josino Costa Moreira Volney de Magalhaes Câmara Carmen Ildes Rodrigues Froes Asmus Ana Cristina Simoes Rosa Paolo Vineis Armando Meyer Exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, Brazil Frontiers in Public Health pyrethroids pregnant women children Rio de Janeiro Brazil |
| title | Exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, Brazil |
| title_full | Exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, Brazil |
| title_fullStr | Exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, Brazil |
| title_full_unstemmed | Exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, Brazil |
| title_short | Exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, Brazil |
| title_sort | exposure of pregnant women and their children to pyrethroid insecticides in rio de janeiro brazil |
| topic | pyrethroids pregnant women children Rio de Janeiro Brazil |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1274724/full |
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