Novel Polymeric Micelles-Coated Magnetic Nanoparticles for In Vivo Bioimaging of Liver: Toxicological Profile and Contrast Enhancement
Magnetic nanoparticles are intensively studied for magnetic resonance imaging (MRI) as contrast agents but yet there remained some gaps regarding their toxicity potential and clinical implications of their biodistribution in organs. This study presents the effects induced by magnetite nanoparticles...
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2020-06-01
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| Online Access: | https://www.mdpi.com/1996-1944/13/12/2722 |
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| author | Ioana Mihaela Popescu Din Mihaela Balas Anca Hermenean Luce Vander Elst Sophie Laurent Carmen Burtea Ludmila Otilia Cinteza Anca Dinischiotu |
| author_facet | Ioana Mihaela Popescu Din Mihaela Balas Anca Hermenean Luce Vander Elst Sophie Laurent Carmen Burtea Ludmila Otilia Cinteza Anca Dinischiotu |
| author_sort | Ioana Mihaela Popescu Din |
| collection | DOAJ |
| description | Magnetic nanoparticles are intensively studied for magnetic resonance imaging (MRI) as contrast agents but yet there remained some gaps regarding their toxicity potential and clinical implications of their biodistribution in organs. This study presents the effects induced by magnetite nanoparticles encapsulated in polymeric micelles (MNP-DSPE-PEG) on biochemical markers, metabolic functions, and MRI signal in CD1 mice liver. Three groups of animals, one control and the other ones injected with a suspension of five, respectively, 15 mg Fe/kg bw nanoparticles, were monitored up to 14 days. The results indicated the presence of MNP-DSPE-PEG in the liver in the first two days of the experiment. The most significant biochemical changes also occurred in the first 3 days after exposure when the most severe histological changes were observed. The change of the MRI signal intensity on the T2-weighted images and increased transverse relaxation rates R<sub>2</sub> in the liver were observed after the first minutes from the nanoparticle administration. The study shows that the alterations of biomarkers level resulting from exposure to MNP-DSPE-PEG are restored in time in mice liver. This was associated with a significant contrast on T2-weighted images and made us conclude that these nanoparticles might be potential candidates for use as a contrast agent in liver medical imaging. |
| first_indexed | 2024-03-10T19:10:16Z |
| format | Article |
| id | doaj.art-887c0d68aa7644aeb7d36e40f0687b9f |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T19:10:16Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-887c0d68aa7644aeb7d36e40f0687b9f2023-11-20T03:53:06ZengMDPI AGMaterials1996-19442020-06-011312272210.3390/ma13122722Novel Polymeric Micelles-Coated Magnetic Nanoparticles for In Vivo Bioimaging of Liver: Toxicological Profile and Contrast EnhancementIoana Mihaela Popescu Din0Mihaela Balas1Anca Hermenean2Luce Vander Elst3Sophie Laurent4Carmen Burtea5Ludmila Otilia Cinteza6Anca Dinischiotu7Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91–95 Splaiul Independentei, 050095 Bucharest, RomaniaDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91–95 Splaiul Independentei, 050095 Bucharest, RomaniaDepartment of Experimental and Applied Biology, Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Rebreanu, 310414 Arad, RomaniaDepartment of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, Faculty of Medicine and Pharmacy, University of Mons, 19, Avenue Maistriau, Mendeleev Building, B-7000 Mons, BelgiumDepartment of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, Faculty of Medicine and Pharmacy, University of Mons, 19, Avenue Maistriau, Mendeleev Building, B-7000 Mons, BelgiumDepartment of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, Faculty of Medicine and Pharmacy, University of Mons, 19, Avenue Maistriau, Mendeleev Building, B-7000 Mons, BelgiumDepartment of Physical Chemistry, Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta Blvd, 030018 Bucharest, RomaniaDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91–95 Splaiul Independentei, 050095 Bucharest, RomaniaMagnetic nanoparticles are intensively studied for magnetic resonance imaging (MRI) as contrast agents but yet there remained some gaps regarding their toxicity potential and clinical implications of their biodistribution in organs. This study presents the effects induced by magnetite nanoparticles encapsulated in polymeric micelles (MNP-DSPE-PEG) on biochemical markers, metabolic functions, and MRI signal in CD1 mice liver. Three groups of animals, one control and the other ones injected with a suspension of five, respectively, 15 mg Fe/kg bw nanoparticles, were monitored up to 14 days. The results indicated the presence of MNP-DSPE-PEG in the liver in the first two days of the experiment. The most significant biochemical changes also occurred in the first 3 days after exposure when the most severe histological changes were observed. The change of the MRI signal intensity on the T2-weighted images and increased transverse relaxation rates R<sub>2</sub> in the liver were observed after the first minutes from the nanoparticle administration. The study shows that the alterations of biomarkers level resulting from exposure to MNP-DSPE-PEG are restored in time in mice liver. This was associated with a significant contrast on T2-weighted images and made us conclude that these nanoparticles might be potential candidates for use as a contrast agent in liver medical imaging.https://www.mdpi.com/1996-1944/13/12/2722polymeric micellesmagnetite nanoparticlescontrast agentstoxicityMRI |
| spellingShingle | Ioana Mihaela Popescu Din Mihaela Balas Anca Hermenean Luce Vander Elst Sophie Laurent Carmen Burtea Ludmila Otilia Cinteza Anca Dinischiotu Novel Polymeric Micelles-Coated Magnetic Nanoparticles for In Vivo Bioimaging of Liver: Toxicological Profile and Contrast Enhancement Materials polymeric micelles magnetite nanoparticles contrast agents toxicity MRI |
| title | Novel Polymeric Micelles-Coated Magnetic Nanoparticles for In Vivo Bioimaging of Liver: Toxicological Profile and Contrast Enhancement |
| title_full | Novel Polymeric Micelles-Coated Magnetic Nanoparticles for In Vivo Bioimaging of Liver: Toxicological Profile and Contrast Enhancement |
| title_fullStr | Novel Polymeric Micelles-Coated Magnetic Nanoparticles for In Vivo Bioimaging of Liver: Toxicological Profile and Contrast Enhancement |
| title_full_unstemmed | Novel Polymeric Micelles-Coated Magnetic Nanoparticles for In Vivo Bioimaging of Liver: Toxicological Profile and Contrast Enhancement |
| title_short | Novel Polymeric Micelles-Coated Magnetic Nanoparticles for In Vivo Bioimaging of Liver: Toxicological Profile and Contrast Enhancement |
| title_sort | novel polymeric micelles coated magnetic nanoparticles for in vivo bioimaging of liver toxicological profile and contrast enhancement |
| topic | polymeric micelles magnetite nanoparticles contrast agents toxicity MRI |
| url | https://www.mdpi.com/1996-1944/13/12/2722 |
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