Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer’s polygenic risk reveals autobiographical deficits and cingulate cortex correlates

Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer’s polygenic risk reveals autobiographical deficits and cingulate cortex correlates

Abstract Background Genome-wide association studies demonstrate that Alzheimer’s disease (AD) has a highly polygenic architecture, where thousands of independent genetic variants explain risk with high classification accuracy. This AD polygenic risk score (AD-PRS) has been previously linked to precl...

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Bibliographic Details
Main Authors: Thomas Lancaster, Byron Creese, Valentina Escott-Price, Ian Driver, Georgina Menzies, Zunera Khan, Anne Corbett, Clive Ballard, Julie Williams, Kevin Murphy, Hannah Chandler
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Alzheimer’s Research & Therapy
Subjects:
Polygenic risk score
Alzheimer’s disease
Recall-by-genotype
Neuroimaging
Online Access:https://doi.org/10.1186/s13195-023-01362-y

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