Retinal vessel volume reference database derived from volume-rendered optical coherence tomography angiography
Abstract Optical coherence tomography angiography (OCTA) enables three-dimensional reconstruction of the functional blood vessels in the retina. Therefore, it enables the quantification of 3D retinal vessel parameters such as surface area and vessel volume. In spite of the widespread use of OCTA, no...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-53000-8 |
| _version_ | 1797275017488105472 |
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| author | Silvia Feu-Basilio Peter M. Maloca Pascal Hasler Hendrik P. N. Scholl Sara Marin-Martinez Josep Rosinés-Fonoll Xavier Suarez-Valero Michael Reich Clemens Lange Catherine Egan Sandrine Zweifel Adnan Tufail Richard F. Spaide Javier Zarranz-Ventura |
| author_facet | Silvia Feu-Basilio Peter M. Maloca Pascal Hasler Hendrik P. N. Scholl Sara Marin-Martinez Josep Rosinés-Fonoll Xavier Suarez-Valero Michael Reich Clemens Lange Catherine Egan Sandrine Zweifel Adnan Tufail Richard F. Spaide Javier Zarranz-Ventura |
| author_sort | Silvia Feu-Basilio |
| collection | DOAJ |
| description | Abstract Optical coherence tomography angiography (OCTA) enables three-dimensional reconstruction of the functional blood vessels in the retina. Therefore, it enables the quantification of 3D retinal vessel parameters such as surface area and vessel volume. In spite of the widespread use of OCTA, no representative volume-rendered vessel volume (VV) data are published to date. In this study, OCTA 3 × 3 mm macular cubes were processed with volume-rendering techniques to measure VV in 203 eyes from 107 healthy volunteers. Generalized linear models (GLM) were constructed to assess the impact of age, gender, visual acuity (VA), spherical equivalent (SE), and axial length (AL) on VV. Overall mean VV was 0.23 ± 0.05mm3. Age and axial length showed a negative correlation with VV. However, GLM model analysis found that AL exerted the most pronounced influence on VV. No statistically significant associations were identified between gender or between left and right eyes. This is the first study to assess 3D OCTA VV and its naturally occurring variations in a large series of healthy subjects. It offers novel insights into the characterization of normal retinal vascular anatomy in healthy individuals, contributing to a valuable reference for future research in this field. |
| first_indexed | 2024-03-07T15:08:19Z |
| format | Article |
| id | doaj.art-888272a4304042d8ac17454051a0fc17 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:08:19Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-888272a4304042d8ac17454051a0fc172024-03-05T18:49:55ZengNature PortfolioScientific Reports2045-23222024-02-011411810.1038/s41598-024-53000-8Retinal vessel volume reference database derived from volume-rendered optical coherence tomography angiographySilvia Feu-Basilio0Peter M. Maloca1Pascal Hasler2Hendrik P. N. Scholl3Sara Marin-Martinez4Josep Rosinés-Fonoll5Xavier Suarez-Valero6Michael Reich7Clemens Lange8Catherine Egan9Sandrine Zweifel10Adnan Tufail11Richard F. Spaide12Javier Zarranz-Ventura13Hospital Clínic de Barcelona, University of BarcelonaInstitute of Molecular and Clinical Ophthalmology BaselInstitute of Molecular and Clinical Ophthalmology BaselInstitute of Molecular and Clinical Ophthalmology BaselHospital Clínic de Barcelona, University of BarcelonaHospital Clínic de Barcelona, University of BarcelonaHospital Clínic de Barcelona, University of BarcelonaFaculty of Medicine, Eye Center, Albert-Ludwig University FreiburgFaculty of Medicine, Eye Center, Albert-Ludwig University FreiburgMoorfields Eye Hospital NHS Foundation TrustDepartment of Ophthalmology, University Hospital ZurichMoorfields Eye Hospital NHS Foundation TrustVitreous, Retina, Macula Consultants of New YorkHospital Clínic de Barcelona, University of BarcelonaAbstract Optical coherence tomography angiography (OCTA) enables three-dimensional reconstruction of the functional blood vessels in the retina. Therefore, it enables the quantification of 3D retinal vessel parameters such as surface area and vessel volume. In spite of the widespread use of OCTA, no representative volume-rendered vessel volume (VV) data are published to date. In this study, OCTA 3 × 3 mm macular cubes were processed with volume-rendering techniques to measure VV in 203 eyes from 107 healthy volunteers. Generalized linear models (GLM) were constructed to assess the impact of age, gender, visual acuity (VA), spherical equivalent (SE), and axial length (AL) on VV. Overall mean VV was 0.23 ± 0.05mm3. Age and axial length showed a negative correlation with VV. However, GLM model analysis found that AL exerted the most pronounced influence on VV. No statistically significant associations were identified between gender or between left and right eyes. This is the first study to assess 3D OCTA VV and its naturally occurring variations in a large series of healthy subjects. It offers novel insights into the characterization of normal retinal vascular anatomy in healthy individuals, contributing to a valuable reference for future research in this field.https://doi.org/10.1038/s41598-024-53000-8 |
| spellingShingle | Silvia Feu-Basilio Peter M. Maloca Pascal Hasler Hendrik P. N. Scholl Sara Marin-Martinez Josep Rosinés-Fonoll Xavier Suarez-Valero Michael Reich Clemens Lange Catherine Egan Sandrine Zweifel Adnan Tufail Richard F. Spaide Javier Zarranz-Ventura Retinal vessel volume reference database derived from volume-rendered optical coherence tomography angiography Scientific Reports |
| title | Retinal vessel volume reference database derived from volume-rendered optical coherence tomography angiography |
| title_full | Retinal vessel volume reference database derived from volume-rendered optical coherence tomography angiography |
| title_fullStr | Retinal vessel volume reference database derived from volume-rendered optical coherence tomography angiography |
| title_full_unstemmed | Retinal vessel volume reference database derived from volume-rendered optical coherence tomography angiography |
| title_short | Retinal vessel volume reference database derived from volume-rendered optical coherence tomography angiography |
| title_sort | retinal vessel volume reference database derived from volume rendered optical coherence tomography angiography |
| url | https://doi.org/10.1038/s41598-024-53000-8 |
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