Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy

Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a lethal muscle-wasting disease. Studies in Drosophila showed that genetic increase of the levels of the bioactive sphingolipid sphingosine-1-phosphate (S1P) or delivery of 2-acetyl-5-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, suppresses dystrophi...

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Bibliographic Details
Main Authors: Diem-Hang Nguyen-Tran, Nitai C. Hait, Henrik Sperber, Junlin Qi, Karin Fischer, Nick Ieronimakis, Mario Pantoja, Aislinn Hays, Jeremy Allegood, Morayma Reyes, Sarah Spiegel, Hannele Ruohola-Baker
Format: Article
Language:English
Published: The Company of Biologists 2014-01-01
Series:Disease Models & Mechanisms
Subjects:
HDAC
S1P
THI
dys
Dystrophin
mdx
Online Access:http://dmm.biologists.org/content/7/1/41

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