A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
Abstract Intracerebral hemorrhage (ICH) remains a common and debilitating form of stroke. This neurological emergency must be diagnosed and treated rapidly yet effectively. In this article, we review the medical, surgical, repair, and regenerative treatment options for managing ICH. Topics of focus...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-11-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51443 |
| _version_ | 1818932171636736000 |
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| author | Humaira Sadaf Virendra R. Desai Vivek Misra Eugene Golanov Muralidhar L. Hegde Sonia Villapol Christof Karmonik Angelique Regnier‐Golanov Dimitri Sayenko Philip J. Horner Robert Krencik Yi Lan Weng Farhaan S. Vahidy Gavin W. Britz |
| author_facet | Humaira Sadaf Virendra R. Desai Vivek Misra Eugene Golanov Muralidhar L. Hegde Sonia Villapol Christof Karmonik Angelique Regnier‐Golanov Dimitri Sayenko Philip J. Horner Robert Krencik Yi Lan Weng Farhaan S. Vahidy Gavin W. Britz |
| author_sort | Humaira Sadaf |
| collection | DOAJ |
| description | Abstract Intracerebral hemorrhage (ICH) remains a common and debilitating form of stroke. This neurological emergency must be diagnosed and treated rapidly yet effectively. In this article, we review the medical, surgical, repair, and regenerative treatment options for managing ICH. Topics of focus include the management of blood pressure, intracranial pressure, coagulopathy, and intraventricular hemorrhage, as well as the role of surgery, regeneration, rehabilitation, and secondary prevention. Results of various phase II and III trials are incorporated. In summary, ICH patients should undergo rapid evaluation with neuroimaging, and early interventions should include systolic blood pressure control in the range of 140 mmHg, correction of coagulopathy if indicated, and assessment for surgical intervention. ICH patients should be managed in dedicated neurosurgical intensive care or stroke units where continuous monitoring of neurological status and evaluation for neurological deterioration is rapidly possible. Extravasation of hematoma may be helpful in patients with intraventricular extension of ICH. The goal of care is to reduce mortality and enable multimodal rehabilitative therapy. |
| first_indexed | 2024-12-20T04:28:15Z |
| format | Article |
| id | doaj.art-88832c0f50434bdb95bd8cdeed490c98 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-20T04:28:15Z |
| publishDate | 2021-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-88832c0f50434bdb95bd8cdeed490c982022-12-21T19:53:27ZengWileyAnnals of Clinical and Translational Neurology2328-95032021-11-018112211222110.1002/acn3.51443A contemporary review of therapeutic and regenerative management of intracerebral hemorrhageHumaira Sadaf0Virendra R. Desai1Vivek Misra2Eugene Golanov3Muralidhar L. Hegde4Sonia Villapol5Christof Karmonik6Angelique Regnier‐Golanov7Dimitri Sayenko8Philip J. Horner9Robert Krencik10Yi Lan Weng11Farhaan S. Vahidy12Gavin W. Britz13Punjab Medical College University of Health Science Faisalabad PakistanDepartment of Neurosurgery Houston Methodist Neurological Institute Houston TexasUSADepartment of Neurology Houston Methodist Neurological Institute Houston TexasUSADepartment of Neurosurgery Houston Methodist Neurological Institute Houston TexasUSADepartment of Neurosurgery Houston Methodist Neurological Institute Houston TexasUSADepartment of Neurosurgery Houston Methodist Neurological Institute Houston TexasUSATranslational Imaging Center Houston Methodist Research Institute Houston TexasUSADepartment of Neurosurgery Houston Methodist Neurological Institute Houston TexasUSADepartment of Neurosurgery Houston Methodist Neurological Institute Houston TexasUSADepartment of Neurosurgery Houston Methodist Neurological Institute Houston TexasUSADepartment of Neurosurgery Houston Methodist Neurological Institute Houston TexasUSADepartment of Neurosurgery Houston Methodist Neurological Institute Houston TexasUSADepartment of Neurosurgery Houston Methodist Neurological Institute Houston TexasUSADepartment of Neurosurgery Houston Methodist Neurological Institute Houston TexasUSAAbstract Intracerebral hemorrhage (ICH) remains a common and debilitating form of stroke. This neurological emergency must be diagnosed and treated rapidly yet effectively. In this article, we review the medical, surgical, repair, and regenerative treatment options for managing ICH. Topics of focus include the management of blood pressure, intracranial pressure, coagulopathy, and intraventricular hemorrhage, as well as the role of surgery, regeneration, rehabilitation, and secondary prevention. Results of various phase II and III trials are incorporated. In summary, ICH patients should undergo rapid evaluation with neuroimaging, and early interventions should include systolic blood pressure control in the range of 140 mmHg, correction of coagulopathy if indicated, and assessment for surgical intervention. ICH patients should be managed in dedicated neurosurgical intensive care or stroke units where continuous monitoring of neurological status and evaluation for neurological deterioration is rapidly possible. Extravasation of hematoma may be helpful in patients with intraventricular extension of ICH. The goal of care is to reduce mortality and enable multimodal rehabilitative therapy.https://doi.org/10.1002/acn3.51443 |
| spellingShingle | Humaira Sadaf Virendra R. Desai Vivek Misra Eugene Golanov Muralidhar L. Hegde Sonia Villapol Christof Karmonik Angelique Regnier‐Golanov Dimitri Sayenko Philip J. Horner Robert Krencik Yi Lan Weng Farhaan S. Vahidy Gavin W. Britz A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage Annals of Clinical and Translational Neurology |
| title | A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage |
| title_full | A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage |
| title_fullStr | A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage |
| title_full_unstemmed | A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage |
| title_short | A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage |
| title_sort | contemporary review of therapeutic and regenerative management of intracerebral hemorrhage |
| url | https://doi.org/10.1002/acn3.51443 |
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