CASPR2 positive autoimmune encephalitis presenting as delirium in an alcohol dependent patient: a diagnostic dilemma

Delirium, a major psychiatric emergency commonly encountered in alcohol withdrawal state, can have various aetiologies. Here we present a case of protracted delirium in an alcohol dependent patient, which on detailed neurological workup was diagnosed to be autoimmune encephalitis with CASPR2 (contac...

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Main Authors: Arya Jith, Kathleen Anne Mathew, Dinesh Narayanan, Sheen Maria Jacob
Format: Article
Language:English
Published: Indian Psychiatric Society (Kerala State Branch 2021-06-01
Series:Kerala Journal of Psychiatry
Subjects:
Online Access:https://kjponline.com/index.php/kjp/article/view/265
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author Arya Jith
Kathleen Anne Mathew
Dinesh Narayanan
Sheen Maria Jacob
author_facet Arya Jith
Kathleen Anne Mathew
Dinesh Narayanan
Sheen Maria Jacob
author_sort Arya Jith
collection DOAJ
description Delirium, a major psychiatric emergency commonly encountered in alcohol withdrawal state, can have various aetiologies. Here we present a case of protracted delirium in an alcohol dependent patient, which on detailed neurological workup was diagnosed to be autoimmune encephalitis with CASPR2 (contactin-associated protein-like 2) antibodies. Subsequent treatment with immunotherapy and steroids lead to the resolution of symptoms.
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spelling doaj.art-888473e1a11748fb9a629361399e8f602022-12-21T19:50:58ZengIndian Psychiatric Society (Kerala State BranchKerala Journal of Psychiatry0377-06992395-14862021-06-0110.30834/KJP.34.1.2021.265223CASPR2 positive autoimmune encephalitis presenting as delirium in an alcohol dependent patient: a diagnostic dilemmaArya Jith0Kathleen Anne Mathew1Dinesh Narayanan2Sheen Maria Jacob3Assistant Professor, Department of Psychiatry, Amrita Institute of Medical sciences, KochiSenior Resident, Department of Psychiatry, Amrita Institute of Medical Sciences, KochiProfessor and Head, Department of Psychiatry, Amrita Institute of Medical Sciences, KochiJunior Resident, Department of psychiatry, Amrita Institute of Medical Sciences, KochiDelirium, a major psychiatric emergency commonly encountered in alcohol withdrawal state, can have various aetiologies. Here we present a case of protracted delirium in an alcohol dependent patient, which on detailed neurological workup was diagnosed to be autoimmune encephalitis with CASPR2 (contactin-associated protein-like 2) antibodies. Subsequent treatment with immunotherapy and steroids lead to the resolution of symptoms.https://kjponline.com/index.php/kjp/article/view/265deliriumautoimmune encephalitisalcohol withdrawalcaspr2
spellingShingle Arya Jith
Kathleen Anne Mathew
Dinesh Narayanan
Sheen Maria Jacob
CASPR2 positive autoimmune encephalitis presenting as delirium in an alcohol dependent patient: a diagnostic dilemma
Kerala Journal of Psychiatry
delirium
autoimmune encephalitis
alcohol withdrawal
caspr2
title CASPR2 positive autoimmune encephalitis presenting as delirium in an alcohol dependent patient: a diagnostic dilemma
title_full CASPR2 positive autoimmune encephalitis presenting as delirium in an alcohol dependent patient: a diagnostic dilemma
title_fullStr CASPR2 positive autoimmune encephalitis presenting as delirium in an alcohol dependent patient: a diagnostic dilemma
title_full_unstemmed CASPR2 positive autoimmune encephalitis presenting as delirium in an alcohol dependent patient: a diagnostic dilemma
title_short CASPR2 positive autoimmune encephalitis presenting as delirium in an alcohol dependent patient: a diagnostic dilemma
title_sort caspr2 positive autoimmune encephalitis presenting as delirium in an alcohol dependent patient a diagnostic dilemma
topic delirium
autoimmune encephalitis
alcohol withdrawal
caspr2
url https://kjponline.com/index.php/kjp/article/view/265
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AT kathleenannemathew caspr2positiveautoimmuneencephalitispresentingasdeliriuminanalcoholdependentpatientadiagnosticdilemma
AT dineshnarayanan caspr2positiveautoimmuneencephalitispresentingasdeliriuminanalcoholdependentpatientadiagnosticdilemma
AT sheenmariajacob caspr2positiveautoimmuneencephalitispresentingasdeliriuminanalcoholdependentpatientadiagnosticdilemma