The Discovery of <i>Vitreoscilla</i> Hemoglobin and Early Studies on Its Biochemical Functions, the Control of Its Expression, and Its Use in Practical Applications
In 1986, the surprising identification of a hemoglobin (VHb) in the bacterium <i>Vitreoscilla</i> greatly extended the range of taxa in which this oxygen binding protein functions. Elucidation of many of its biochemical properties and relation to overall cell physiology, as well as the s...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/8/1637 |
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| author | Dale A. Webster Kanak L. Dikshit Krishna R. Pagilla Benjamin C. Stark |
| author_facet | Dale A. Webster Kanak L. Dikshit Krishna R. Pagilla Benjamin C. Stark |
| author_sort | Dale A. Webster |
| collection | DOAJ |
| description | In 1986, the surprising identification of a hemoglobin (VHb) in the bacterium <i>Vitreoscilla</i> greatly extended the range of taxa in which this oxygen binding protein functions. Elucidation of many of its biochemical properties and relation to overall cell physiology, as well as the sequence of the gene encoding it and aspects of control of its expression were determined in the following years. In addition, during the early years following its discovery, strategies were developed to use its expression in heterologous microbial hosts to enhance processes of practical usefulness. The VHb discovery also served as the foundation for what has become the fascinatingly rich field of bacterial hemoglobins. VHb’s position as the first known bacterial hemoglobin and its extensive use in biotechnological applications, which continue today, make a review of the early studies of its properties and uses an appropriate and interesting topic thirty-five years after its discovery. |
| first_indexed | 2024-03-10T08:34:19Z |
| format | Article |
| id | doaj.art-88890b8250464bd3b40b059b67e0a545 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T08:34:19Z |
| publishDate | 2021-07-01 |
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| series | Microorganisms |
| spelling | doaj.art-88890b8250464bd3b40b059b67e0a5452023-11-22T08:46:39ZengMDPI AGMicroorganisms2076-26072021-07-0198163710.3390/microorganisms9081637The Discovery of <i>Vitreoscilla</i> Hemoglobin and Early Studies on Its Biochemical Functions, the Control of Its Expression, and Its Use in Practical ApplicationsDale A. Webster0Kanak L. Dikshit1Krishna R. Pagilla2Benjamin C. Stark3Department of Biology, Illinois Institute of Technology, Chicago, IL 60616, USADepartment of Biotechnology, Panjab University, Chandigarh 160014, IndiaDepartment of Civil and Environmental Engineering, University of Nevada at Reno, Reno, NV 89557, USADepartment of Biology, Illinois Institute of Technology, Chicago, IL 60616, USAIn 1986, the surprising identification of a hemoglobin (VHb) in the bacterium <i>Vitreoscilla</i> greatly extended the range of taxa in which this oxygen binding protein functions. Elucidation of many of its biochemical properties and relation to overall cell physiology, as well as the sequence of the gene encoding it and aspects of control of its expression were determined in the following years. In addition, during the early years following its discovery, strategies were developed to use its expression in heterologous microbial hosts to enhance processes of practical usefulness. The VHb discovery also served as the foundation for what has become the fascinatingly rich field of bacterial hemoglobins. VHb’s position as the first known bacterial hemoglobin and its extensive use in biotechnological applications, which continue today, make a review of the early studies of its properties and uses an appropriate and interesting topic thirty-five years after its discovery.https://www.mdpi.com/2076-2607/9/8/1637<i>Vitreoscilla</i> hemoglobinoxygen metabolismgenetically modified organismsbiotechnological applications |
| spellingShingle | Dale A. Webster Kanak L. Dikshit Krishna R. Pagilla Benjamin C. Stark The Discovery of <i>Vitreoscilla</i> Hemoglobin and Early Studies on Its Biochemical Functions, the Control of Its Expression, and Its Use in Practical Applications Microorganisms <i>Vitreoscilla</i> hemoglobin oxygen metabolism genetically modified organisms biotechnological applications |
| title | The Discovery of <i>Vitreoscilla</i> Hemoglobin and Early Studies on Its Biochemical Functions, the Control of Its Expression, and Its Use in Practical Applications |
| title_full | The Discovery of <i>Vitreoscilla</i> Hemoglobin and Early Studies on Its Biochemical Functions, the Control of Its Expression, and Its Use in Practical Applications |
| title_fullStr | The Discovery of <i>Vitreoscilla</i> Hemoglobin and Early Studies on Its Biochemical Functions, the Control of Its Expression, and Its Use in Practical Applications |
| title_full_unstemmed | The Discovery of <i>Vitreoscilla</i> Hemoglobin and Early Studies on Its Biochemical Functions, the Control of Its Expression, and Its Use in Practical Applications |
| title_short | The Discovery of <i>Vitreoscilla</i> Hemoglobin and Early Studies on Its Biochemical Functions, the Control of Its Expression, and Its Use in Practical Applications |
| title_sort | discovery of i vitreoscilla i hemoglobin and early studies on its biochemical functions the control of its expression and its use in practical applications |
| topic | <i>Vitreoscilla</i> hemoglobin oxygen metabolism genetically modified organisms biotechnological applications |
| url | https://www.mdpi.com/2076-2607/9/8/1637 |
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