Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose.

Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose.

Neurogenesis in the adult hippocampus contributes to learning and memory in the healthy brain but is dysregulated in metabolic and neurodegenerative diseases. The molecular relationships between neural stem cell activity, adult neurogenesis, and global metabolism are largely unknown. Here we applied...

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Bibliographic Details
Main Authors: Anna N Senko, Rupert W Overall, Jan Silhavy, Petr Mlejnek, Hana Malínská, Martina Hüttl, Irena Marková, Klaus S Fabel, Lu Lu, Ales Stuchlik, Robert W Williams, Michal Pravenec, Gerd Kempermann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-04-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009638

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