The Discovery of Bifenazate, a Novel Carbazate Acaricide
A history of the discovery of the novel carbazate acaricide, bifenazate, is outlined. When a novel ortho-biphenyl substituted hydrazide compound showed acaricidal activity in the pesticide discovery screen, a small number of analogs were made to confirm and explore acaricidal effects. An o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2003-11-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/3771 |
| _version_ | 1798013930859134976 |
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| author | Mark A. Dekeyser Paul T. McDonald Gilbert W. Angle |
| author_facet | Mark A. Dekeyser Paul T. McDonald Gilbert W. Angle |
| author_sort | Mark A. Dekeyser |
| collection | DOAJ |
| description |
A history of the discovery of the novel carbazate acaricide, bifenazate, is outlined. When a novel ortho-biphenyl substituted hydrazide compound showed acaricidal activity in the pesticide discovery screen, a small number of analogs were made to confirm and explore acaricidal
effects. An ortho-biphenylcarbazate analog gave significantly greater acaricidal activity. Thereafter, several hundred structurally-diverse biphenyl-substituted carbazate analogs were synthesized and evaluated in a bioassay with the two-spotted spider mite (Tetranychus urticae
Koch) in order to optimize the acaricidal activity. As a result of the optimization process, bifenazate, the analog with a methoxybiphenyl substituent to the terminal nitrogen atom of isopropyl carbazate, was selected for development and registration.
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| first_indexed | 2024-04-11T15:10:39Z |
| format | Article |
| id | doaj.art-888d5b04786c414fbd31436624c543e6 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-11T15:10:39Z |
| publishDate | 2003-11-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-888d5b04786c414fbd31436624c543e62022-12-22T04:16:40ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242003-11-01571110.2533/000942903777678533The Discovery of Bifenazate, a Novel Carbazate AcaricideMark A. DekeyserPaul T. McDonaldGilbert W. Angle A history of the discovery of the novel carbazate acaricide, bifenazate, is outlined. When a novel ortho-biphenyl substituted hydrazide compound showed acaricidal activity in the pesticide discovery screen, a small number of analogs were made to confirm and explore acaricidal effects. An ortho-biphenylcarbazate analog gave significantly greater acaricidal activity. Thereafter, several hundred structurally-diverse biphenyl-substituted carbazate analogs were synthesized and evaluated in a bioassay with the two-spotted spider mite (Tetranychus urticae Koch) in order to optimize the acaricidal activity. As a result of the optimization process, bifenazate, the analog with a methoxybiphenyl substituent to the terminal nitrogen atom of isopropyl carbazate, was selected for development and registration. https://chimia.ch/chimia/article/view/3771AcaricideBifenazateCarbazateDiscovery |
| spellingShingle | Mark A. Dekeyser Paul T. McDonald Gilbert W. Angle The Discovery of Bifenazate, a Novel Carbazate Acaricide CHIMIA Acaricide Bifenazate Carbazate Discovery |
| title | The Discovery of Bifenazate, a Novel Carbazate Acaricide |
| title_full | The Discovery of Bifenazate, a Novel Carbazate Acaricide |
| title_fullStr | The Discovery of Bifenazate, a Novel Carbazate Acaricide |
| title_full_unstemmed | The Discovery of Bifenazate, a Novel Carbazate Acaricide |
| title_short | The Discovery of Bifenazate, a Novel Carbazate Acaricide |
| title_sort | discovery of bifenazate a novel carbazate acaricide |
| topic | Acaricide Bifenazate Carbazate Discovery |
| url | https://chimia.ch/chimia/article/view/3771 |
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