Case study: Thyrotoxicosis on women with complete hydatidiform molar pregnancy
Thyrotoxicosis defined as a clinical manifestation of excess circulating thyroid hormone. Epidemiologic investigation reports 0.2% of thyrotoxicosis is caused by hydatidiform mole. The New England Trophoblastic Disease Centre (NETDC) mentioned that 20% of hydatidiform mole cases have thyrotoxicosis...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine
2019-12-01
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| Series: | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| Subjects: | |
| Online Access: | https://journal.uii.ac.id/JKKI/article/view/14281 |
| _version_ | 1818858045421125632 |
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| author | Gagah Baskara Adi Nugraha Pugud Samodro |
| author_facet | Gagah Baskara Adi Nugraha Pugud Samodro |
| author_sort | Gagah Baskara Adi Nugraha |
| collection | DOAJ |
| description | Thyrotoxicosis defined as a clinical manifestation of excess circulating thyroid hormone. Epidemiologic investigation reports 0.2% of thyrotoxicosis is caused by hydatidiform mole. The New England Trophoblastic Disease Centre (NETDC) mentioned that 20% of hydatidiform mole cases have thyrotoxicosis as one of its complications. The basic pathogenesis of thyrotoxicosis is the similarity of the HCG subunit to TSH which results in excessive stimulation of thyroid hormone. We present thethyrotoxicosis case in a 15-weeks pregnant woman with complete hydatidiform mole. The patient admitted to the hospital with blackish-red coloured bleeding and several hyperthyroidism complaints , laboratory test showed elevated levels of HCG and thyroid hormone and decreased TSH. Imaging studies done with ultrasound showed with snowflake pattern. The patient then treated with thyroid hormone suppressant therapy before the hydatidiform mole evacuation. Normalization of thyroid hormone levels should be made immediately before the mole evacuation to avoid life-threatening thyroid storm complications. |
| first_indexed | 2024-12-19T08:50:03Z |
| format | Article |
| id | doaj.art-888ee7c9fe2d44409adc647a5babc6e2 |
| institution | Directory Open Access Journal |
| issn | 2085-4145 2527-2950 |
| language | English |
| last_indexed | 2024-12-19T08:50:03Z |
| publishDate | 2019-12-01 |
| publisher | Faculty of Medicine |
| record_format | Article |
| series | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| spelling | doaj.art-888ee7c9fe2d44409adc647a5babc6e22022-12-21T20:28:44ZengFaculty of MedicineJKKI (Jurnal Kedokteran dan Kesehatan Indonesia)2085-41452527-29502019-12-0110329229710.20885/JKKI.Vol10.Iss3.art139242Case study: Thyrotoxicosis on women with complete hydatidiform molar pregnancyGagah Baskara Adi Nugraha0Pugud Samodro1Internship General Practitioner at Ajibarang General Hospital, Banyumas, IndonesiaIntenist, Consultant of Endocrine Metabolic and Diabetes at Prof. Dr. Margono Soekarjo General Hospital, Purwokerto, IndonesiaThyrotoxicosis defined as a clinical manifestation of excess circulating thyroid hormone. Epidemiologic investigation reports 0.2% of thyrotoxicosis is caused by hydatidiform mole. The New England Trophoblastic Disease Centre (NETDC) mentioned that 20% of hydatidiform mole cases have thyrotoxicosis as one of its complications. The basic pathogenesis of thyrotoxicosis is the similarity of the HCG subunit to TSH which results in excessive stimulation of thyroid hormone. We present thethyrotoxicosis case in a 15-weeks pregnant woman with complete hydatidiform mole. The patient admitted to the hospital with blackish-red coloured bleeding and several hyperthyroidism complaints , laboratory test showed elevated levels of HCG and thyroid hormone and decreased TSH. Imaging studies done with ultrasound showed with snowflake pattern. The patient then treated with thyroid hormone suppressant therapy before the hydatidiform mole evacuation. Normalization of thyroid hormone levels should be made immediately before the mole evacuation to avoid life-threatening thyroid storm complications.https://journal.uii.ac.id/JKKI/article/view/14281thyrotoxicosishydatidiform molepregnancyhcg |
| spellingShingle | Gagah Baskara Adi Nugraha Pugud Samodro Case study: Thyrotoxicosis on women with complete hydatidiform molar pregnancy JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) thyrotoxicosis hydatidiform mole pregnancy hcg |
| title | Case study: Thyrotoxicosis on women with complete hydatidiform molar pregnancy |
| title_full | Case study: Thyrotoxicosis on women with complete hydatidiform molar pregnancy |
| title_fullStr | Case study: Thyrotoxicosis on women with complete hydatidiform molar pregnancy |
| title_full_unstemmed | Case study: Thyrotoxicosis on women with complete hydatidiform molar pregnancy |
| title_short | Case study: Thyrotoxicosis on women with complete hydatidiform molar pregnancy |
| title_sort | case study thyrotoxicosis on women with complete hydatidiform molar pregnancy |
| topic | thyrotoxicosis hydatidiform mole pregnancy hcg |
| url | https://journal.uii.ac.id/JKKI/article/view/14281 |
| work_keys_str_mv | AT gagahbaskaraadinugraha casestudythyrotoxicosisonwomenwithcompletehydatidiformmolarpregnancy AT pugudsamodro casestudythyrotoxicosisonwomenwithcompletehydatidiformmolarpregnancy |