Functional brain alterations following mild-to-moderate sensorineural hearing loss in children
Auditory deprivation in the form of deafness during development leads to lasting changes in central auditory system function. However, less is known about the effects of mild-to-moderate sensorineural hearing loss (MMHL) during development. Here, we used a longitudinal design to examine late auditor...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2019-10-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/46965 |
| _version_ | 1818019880302018560 |
|---|---|
| author | Axelle Calcus Outi Tuomainen Ana Campos Stuart Rosen Lorna F Halliday |
| author_facet | Axelle Calcus Outi Tuomainen Ana Campos Stuart Rosen Lorna F Halliday |
| author_sort | Axelle Calcus |
| collection | DOAJ |
| description | Auditory deprivation in the form of deafness during development leads to lasting changes in central auditory system function. However, less is known about the effects of mild-to-moderate sensorineural hearing loss (MMHL) during development. Here, we used a longitudinal design to examine late auditory evoked responses and mismatch responses to nonspeech and speech sounds for children with MMHL. At Time 1, younger children with MMHL (8–12 years; n = 23) showed age-appropriate mismatch negativities (MMNs) to sounds, but older children (12–16 years; n = 23) did not. Six years later, we re-tested a subset of the younger (now older) children with MMHL (n = 13). Children who had shown significant MMNs at Time 1 showed MMNs that were reduced and, for nonspeech, absent at Time 2. Our findings demonstrate that even a mild-to-moderate hearing loss during early-to-mid childhood can lead to changes in the neural processing of sounds in late childhood/adolescence. |
| first_indexed | 2024-04-14T07:58:35Z |
| format | Article |
| id | doaj.art-888eebb6ae024f709d3f2c0d08171891 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:58:35Z |
| publishDate | 2019-10-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-888eebb6ae024f709d3f2c0d081718912022-12-22T02:04:58ZengeLife Sciences Publications LtdeLife2050-084X2019-10-01810.7554/eLife.46965Functional brain alterations following mild-to-moderate sensorineural hearing loss in childrenAxelle Calcus0https://orcid.org/0000-0002-1240-1122Outi Tuomainen1Ana Campos2Stuart Rosen3Lorna F Halliday4https://orcid.org/0000-0003-1883-7741Laboratoire des Systèmes Perceptifs, Département d’Etudes Cognitives, Ecole Normale Supérieure, PSL University, CNRS, Paris, France; Department of Speech, Hearing and Phonetic Sciences, University College London, London, United KingdomDepartment of Speech, Hearing and Phonetic Sciences, University College London, London, United KingdomDepartment of Speech, Hearing and Phonetic Sciences, University College London, London, United KingdomDepartment of Speech, Hearing and Phonetic Sciences, University College London, London, United KingdomDepartment of Speech, Hearing and Phonetic Sciences, University College London, London, United Kingdom; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United KingdomAuditory deprivation in the form of deafness during development leads to lasting changes in central auditory system function. However, less is known about the effects of mild-to-moderate sensorineural hearing loss (MMHL) during development. Here, we used a longitudinal design to examine late auditory evoked responses and mismatch responses to nonspeech and speech sounds for children with MMHL. At Time 1, younger children with MMHL (8–12 years; n = 23) showed age-appropriate mismatch negativities (MMNs) to sounds, but older children (12–16 years; n = 23) did not. Six years later, we re-tested a subset of the younger (now older) children with MMHL (n = 13). Children who had shown significant MMNs at Time 1 showed MMNs that were reduced and, for nonspeech, absent at Time 2. Our findings demonstrate that even a mild-to-moderate hearing loss during early-to-mid childhood can lead to changes in the neural processing of sounds in late childhood/adolescence.https://elifesciences.org/articles/46965auditorydevelopmenthearing lossLAERMMN |
| spellingShingle | Axelle Calcus Outi Tuomainen Ana Campos Stuart Rosen Lorna F Halliday Functional brain alterations following mild-to-moderate sensorineural hearing loss in children eLife auditory development hearing loss LAER MMN |
| title | Functional brain alterations following mild-to-moderate sensorineural hearing loss in children |
| title_full | Functional brain alterations following mild-to-moderate sensorineural hearing loss in children |
| title_fullStr | Functional brain alterations following mild-to-moderate sensorineural hearing loss in children |
| title_full_unstemmed | Functional brain alterations following mild-to-moderate sensorineural hearing loss in children |
| title_short | Functional brain alterations following mild-to-moderate sensorineural hearing loss in children |
| title_sort | functional brain alterations following mild to moderate sensorineural hearing loss in children |
| topic | auditory development hearing loss LAER MMN |
| url | https://elifesciences.org/articles/46965 |
| work_keys_str_mv | AT axellecalcus functionalbrainalterationsfollowingmildtomoderatesensorineuralhearinglossinchildren AT outituomainen functionalbrainalterationsfollowingmildtomoderatesensorineuralhearinglossinchildren AT anacampos functionalbrainalterationsfollowingmildtomoderatesensorineuralhearinglossinchildren AT stuartrosen functionalbrainalterationsfollowingmildtomoderatesensorineuralhearinglossinchildren AT lornafhalliday functionalbrainalterationsfollowingmildtomoderatesensorineuralhearinglossinchildren |