Cryoglobulinemic glomerulonephritis — lessons from animal models
In humans cryoglobulinemic glomerulonephritis (CGGN) may develop in the course of systemic cryoglobulinemia (CG) and is often associated with hepatitis C virus infection. It is believed that the glomerular injury in CG results from the deposition of immune complexes, but exact sequence of events in...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Via Medica
2012-01-01
|
| Series: | Folia Histochemica et Cytobiologica |
| Subjects: | |
| Online Access: | http://czasopisma.viamedica.pl/fhc/article/view/14713 |
| _version_ | 1818554446373715968 |
|---|---|
| author | Jolanta Kowalewska |
| author_facet | Jolanta Kowalewska |
| author_sort | Jolanta Kowalewska |
| collection | DOAJ |
| description | In humans cryoglobulinemic glomerulonephritis (CGGN) may develop in the course of systemic cryoglobulinemia (CG) and is often associated with hepatitis C virus infection. It is believed that the glomerular injury in CG results from the deposition of immune complexes, but exact sequence of events in this process is unknown. Experimental models of CGGN provide an important tool to study pathogenesis of this type injury. This review describes two mouse models of CGGN and their use in understanding the role of various molecules involved in regulation of inflammatory and fibrosis pathways, such as complement components, Fc receptors, growth factors, and others; as well as illustrates their role in testing novel approaches of treatment in this type of renal injury. (<i>Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 537&#8211;546</i>) |
| first_indexed | 2024-12-12T09:39:36Z |
| format | Article |
| id | doaj.art-888f5af090eb43bcae48b4d84843e8df |
| institution | Directory Open Access Journal |
| issn | 0239-8508 1897-5631 |
| language | English |
| last_indexed | 2024-12-12T09:39:36Z |
| publishDate | 2012-01-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Folia Histochemica et Cytobiologica |
| spelling | doaj.art-888f5af090eb43bcae48b4d84843e8df2022-12-22T00:28:36ZengVia MedicaFolia Histochemica et Cytobiologica0239-85081897-56312012-01-0149453754610.5603/14713Cryoglobulinemic glomerulonephritis &#8212; lessons from animal modelsJolanta KowalewskaIn humans cryoglobulinemic glomerulonephritis (CGGN) may develop in the course of systemic cryoglobulinemia (CG) and is often associated with hepatitis C virus infection. It is believed that the glomerular injury in CG results from the deposition of immune complexes, but exact sequence of events in this process is unknown. Experimental models of CGGN provide an important tool to study pathogenesis of this type injury. This review describes two mouse models of CGGN and their use in understanding the role of various molecules involved in regulation of inflammatory and fibrosis pathways, such as complement components, Fc receptors, growth factors, and others; as well as illustrates their role in testing novel approaches of treatment in this type of renal injury. (<i>Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 537&#8211;546</i>)http://czasopisma.viamedica.pl/fhc/article/view/14713cryoglobulinemiaglomerulonephritisanimal models |
| spellingShingle | Jolanta Kowalewska Cryoglobulinemic glomerulonephritis &#8212; lessons from animal models Folia Histochemica et Cytobiologica cryoglobulinemia glomerulonephritis animal models |
| title | Cryoglobulinemic glomerulonephritis &#8212; lessons from animal models |
| title_full | Cryoglobulinemic glomerulonephritis &#8212; lessons from animal models |
| title_fullStr | Cryoglobulinemic glomerulonephritis &#8212; lessons from animal models |
| title_full_unstemmed | Cryoglobulinemic glomerulonephritis &#8212; lessons from animal models |
| title_short | Cryoglobulinemic glomerulonephritis &#8212; lessons from animal models |
| title_sort | cryoglobulinemic glomerulonephritis amp 8212 lessons from animal models |
| topic | cryoglobulinemia glomerulonephritis animal models |
| url | http://czasopisma.viamedica.pl/fhc/article/view/14713 |
| work_keys_str_mv | AT jolantakowalewska cryoglobulinemicglomerulonephritisamp8212lessonsfromanimalmodels |