Adiposity Measurements and Metabolic Syndrome Are Linked Through Circulating Neuregulin 4 and Adipsin Levels in Obese Adults
BackgroundAdiposity and adipokines are associated with metabolic disorders, but little is known regarding that whether adiposity measurements link metabolic syndrome (MetS) through circulating neuregulin 4 (Nrg4) and adipsin levels.Materials and MethodsA total of 1212 subjects with a waist circumfer...
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.667330/full |
| _version_ | 1819131230769119232 |
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| author | Dan Guo Jianfang Liu Peizhen Zhang Xiaoyu Yang Deying Liu Jiayang Lin Xueyun Wei Bingyan Xu Chensihan Huang Xuan Zhou Fei Teng Hong Zhu Huijie Zhang Huijie Zhang Huijie Zhang |
| author_facet | Dan Guo Jianfang Liu Peizhen Zhang Xiaoyu Yang Deying Liu Jiayang Lin Xueyun Wei Bingyan Xu Chensihan Huang Xuan Zhou Fei Teng Hong Zhu Huijie Zhang Huijie Zhang Huijie Zhang |
| author_sort | Dan Guo |
| collection | DOAJ |
| description | BackgroundAdiposity and adipokines are associated with metabolic disorders, but little is known regarding that whether adiposity measurements link metabolic syndrome (MetS) through circulating neuregulin 4 (Nrg4) and adipsin levels.Materials and MethodsA total of 1212 subjects with a waist circumference greater than 90 cm for men or 80 cm for women were enrolled from a Chinese community. Circulating Nrg4 and adipsin levels were measured using commercial kits. Mediation analyses of circulating Nrg4 and adipsin were performed in the study using linear and logistic regression.ResultsSubjects with MetS had higher waist circumference, visceral fat level, and circulating adipsin level, and lower levels of circulating Nrg4 and muscle mass to visceral fat (MVF) ratio (all P < 0.05). In multivariable logistic regression analyses, after adjusting for confounding variables, per standard deviation (SD) increase in waist circumference and visceral fat level were significantly associated with increased odds of MetS [OR (95% CI), 1.42 (1.22–1.64); 2.20 (1.62–2.99); respectively]; and per SD reduction in MVF ratio was significantly associated with reduced odds of MetS [OR (95% CI), 0.65 (0.55–0.77)]. In the mediation analyses, both circulating Nrg4 and adipsin levels mediated the association between waist circumference (8.31% and 18.35%, respectively), visceral fat level (7.50% and 9.98%, respectively), and MVF ratio (5.80% and 9.86%, respectively) and MetS after adjustments.ConclusionThese findings indicate that adiposity measurements and MetS are linked through circulating Nrg4 and adipsin levels in obese adults, suggesting that circulating Nrg4 and adipsin levels might be potential predictors for management of MetS. |
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| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-22T09:12:12Z |
| publishDate | 2021-05-01 |
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| series | Frontiers in Physiology |
| spelling | doaj.art-88910e6570f84c718d2ecd2cbacbbf752022-12-21T18:31:25ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-05-011210.3389/fphys.2021.667330667330Adiposity Measurements and Metabolic Syndrome Are Linked Through Circulating Neuregulin 4 and Adipsin Levels in Obese AdultsDan Guo0Jianfang Liu1Peizhen Zhang2Xiaoyu Yang3Deying Liu4Jiayang Lin5Xueyun Wei6Bingyan Xu7Chensihan Huang8Xuan Zhou9Fei Teng10Hong Zhu11Huijie Zhang12Huijie Zhang13Huijie Zhang14Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, ChinaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaNanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, ChinaSchool of Public Health, Southern Medical University, Guangzhou, ChinaBackgroundAdiposity and adipokines are associated with metabolic disorders, but little is known regarding that whether adiposity measurements link metabolic syndrome (MetS) through circulating neuregulin 4 (Nrg4) and adipsin levels.Materials and MethodsA total of 1212 subjects with a waist circumference greater than 90 cm for men or 80 cm for women were enrolled from a Chinese community. Circulating Nrg4 and adipsin levels were measured using commercial kits. Mediation analyses of circulating Nrg4 and adipsin were performed in the study using linear and logistic regression.ResultsSubjects with MetS had higher waist circumference, visceral fat level, and circulating adipsin level, and lower levels of circulating Nrg4 and muscle mass to visceral fat (MVF) ratio (all P < 0.05). In multivariable logistic regression analyses, after adjusting for confounding variables, per standard deviation (SD) increase in waist circumference and visceral fat level were significantly associated with increased odds of MetS [OR (95% CI), 1.42 (1.22–1.64); 2.20 (1.62–2.99); respectively]; and per SD reduction in MVF ratio was significantly associated with reduced odds of MetS [OR (95% CI), 0.65 (0.55–0.77)]. In the mediation analyses, both circulating Nrg4 and adipsin levels mediated the association between waist circumference (8.31% and 18.35%, respectively), visceral fat level (7.50% and 9.98%, respectively), and MVF ratio (5.80% and 9.86%, respectively) and MetS after adjustments.ConclusionThese findings indicate that adiposity measurements and MetS are linked through circulating Nrg4 and adipsin levels in obese adults, suggesting that circulating Nrg4 and adipsin levels might be potential predictors for management of MetS.https://www.frontiersin.org/articles/10.3389/fphys.2021.667330/fullneuregulin 4adipsinadipositymetabolic syndromemetabolismmediation analysis |
| spellingShingle | Dan Guo Jianfang Liu Peizhen Zhang Xiaoyu Yang Deying Liu Jiayang Lin Xueyun Wei Bingyan Xu Chensihan Huang Xuan Zhou Fei Teng Hong Zhu Huijie Zhang Huijie Zhang Huijie Zhang Adiposity Measurements and Metabolic Syndrome Are Linked Through Circulating Neuregulin 4 and Adipsin Levels in Obese Adults Frontiers in Physiology neuregulin 4 adipsin adiposity metabolic syndrome metabolism mediation analysis |
| title | Adiposity Measurements and Metabolic Syndrome Are Linked Through Circulating Neuregulin 4 and Adipsin Levels in Obese Adults |
| title_full | Adiposity Measurements and Metabolic Syndrome Are Linked Through Circulating Neuregulin 4 and Adipsin Levels in Obese Adults |
| title_fullStr | Adiposity Measurements and Metabolic Syndrome Are Linked Through Circulating Neuregulin 4 and Adipsin Levels in Obese Adults |
| title_full_unstemmed | Adiposity Measurements and Metabolic Syndrome Are Linked Through Circulating Neuregulin 4 and Adipsin Levels in Obese Adults |
| title_short | Adiposity Measurements and Metabolic Syndrome Are Linked Through Circulating Neuregulin 4 and Adipsin Levels in Obese Adults |
| title_sort | adiposity measurements and metabolic syndrome are linked through circulating neuregulin 4 and adipsin levels in obese adults |
| topic | neuregulin 4 adipsin adiposity metabolic syndrome metabolism mediation analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.667330/full |
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