Investigation the Effect of Valproate on Locomotor Activity, Balance, Lipid Profile, and Serum Biochemical Parameters before Sexual Maturity in Rat
Introduction: Valproate as an effective antiepileptic drug is used for the treatment of partial and generalized seizure in adults and children. This medication causes biochemical changes in liver functions and behavioral changes in childhood. Therefore, this study evaluated the effects of valproate...
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| Format: | Article |
| Language: | fas |
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Ilam University of Medical Sciences
2019-04-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
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| Online Access: | http://sjimu.medilam.ac.ir/article-1-4605-en.html |
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| author | Raha Zalkhani Hossein Najafzadevarzi Ahmad Ali Moazi Zohreh Ghotbeddin |
| author_facet | Raha Zalkhani Hossein Najafzadevarzi Ahmad Ali Moazi Zohreh Ghotbeddin |
| author_sort | Raha Zalkhani |
| collection | DOAJ |
| description | Introduction: Valproate as an effective antiepileptic drug is used for the treatment of partial and generalized seizure in adults and children. This medication causes biochemical changes in liver functions and behavioral changes in childhood. Therefore, this study evaluated the effects of valproate on locomotor activity, balance, hepatic enzymes, and serum lipid profiles in immature female rats.
Materials & Methods: Postnatal female rats (23 days) were divided in two groups. The first group received valproate (200 mg/Kg/day) for two weeks and the second received saline. All injections were performed intraperitoneally. Locomotor activity and balance were evaluated using open field and rotarod apparatus, respectively. Subsequently, cholesterol (HDL, LDL, TC), triglyceride (TG), SGOT and SGPT enzymes in serum were measured.
Findings: Valproate decreased motor activity and increased hepatic enzymes (SGPT) and alkaline phosphatase. However, it had no effect on balance and serum lipid profiles.
Discussion &Conclusions: Subchronic injection of valproate has probably no effect on serum lipid profiles while increasing serum hepatic enzymes and reducing locomotor activity. Therefore, it seems that side effects of valproate occur with its long-term administration. |
| first_indexed | 2024-12-19T00:03:44Z |
| format | Article |
| id | doaj.art-889238ea7343486cad22c53931da4aac |
| institution | Directory Open Access Journal |
| issn | 1563-4728 2588-3135 |
| language | fas |
| last_indexed | 2024-12-19T00:03:44Z |
| publishDate | 2019-04-01 |
| publisher | Ilam University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
| spelling | doaj.art-889238ea7343486cad22c53931da4aac2022-12-21T20:46:21ZfasIlam University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām1563-47282588-31352019-04-0127195103Investigation the Effect of Valproate on Locomotor Activity, Balance, Lipid Profile, and Serum Biochemical Parameters before Sexual Maturity in RatRaha Zalkhani0Hossein Najafzadevarzi1Ahmad Ali Moazi2Zohreh Ghotbeddin3 Dept of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran Dept of Pharmacology, Faculty of Veterinary medicine, Shahid Chamran University of Ahvaz,Iran Dept of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran Dept of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran Introduction: Valproate as an effective antiepileptic drug is used for the treatment of partial and generalized seizure in adults and children. This medication causes biochemical changes in liver functions and behavioral changes in childhood. Therefore, this study evaluated the effects of valproate on locomotor activity, balance, hepatic enzymes, and serum lipid profiles in immature female rats. Materials & Methods: Postnatal female rats (23 days) were divided in two groups. The first group received valproate (200 mg/Kg/day) for two weeks and the second received saline. All injections were performed intraperitoneally. Locomotor activity and balance were evaluated using open field and rotarod apparatus, respectively. Subsequently, cholesterol (HDL, LDL, TC), triglyceride (TG), SGOT and SGPT enzymes in serum were measured. Findings: Valproate decreased motor activity and increased hepatic enzymes (SGPT) and alkaline phosphatase. However, it had no effect on balance and serum lipid profiles. Discussion &Conclusions: Subchronic injection of valproate has probably no effect on serum lipid profiles while increasing serum hepatic enzymes and reducing locomotor activity. Therefore, it seems that side effects of valproate occur with its long-term administration.http://sjimu.medilam.ac.ir/article-1-4605-en.htmlbiochemical parameterslipid profilelocomotor activitybalancevalproaterat |
| spellingShingle | Raha Zalkhani Hossein Najafzadevarzi Ahmad Ali Moazi Zohreh Ghotbeddin Investigation the Effect of Valproate on Locomotor Activity, Balance, Lipid Profile, and Serum Biochemical Parameters before Sexual Maturity in Rat Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām biochemical parameters lipid profile locomotor activity balance valproate rat |
| title | Investigation the Effect of Valproate on Locomotor Activity,
Balance, Lipid Profile, and Serum Biochemical
Parameters before Sexual
Maturity in Rat |
| title_full | Investigation the Effect of Valproate on Locomotor Activity,
Balance, Lipid Profile, and Serum Biochemical
Parameters before Sexual
Maturity in Rat |
| title_fullStr | Investigation the Effect of Valproate on Locomotor Activity,
Balance, Lipid Profile, and Serum Biochemical
Parameters before Sexual
Maturity in Rat |
| title_full_unstemmed | Investigation the Effect of Valproate on Locomotor Activity,
Balance, Lipid Profile, and Serum Biochemical
Parameters before Sexual
Maturity in Rat |
| title_short | Investigation the Effect of Valproate on Locomotor Activity,
Balance, Lipid Profile, and Serum Biochemical
Parameters before Sexual
Maturity in Rat |
| title_sort | investigation the effect of valproate on locomotor activity balance lipid profile and serum biochemical parameters before sexual maturity in rat |
| topic | biochemical parameters lipid profile locomotor activity balance valproate rat |
| url | http://sjimu.medilam.ac.ir/article-1-4605-en.html |
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