Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis
<em>Background:</em>Organophosphate (OP) poisoning is still a major health concern in both developed and developing countries. The standard treatment approaches of (OP) poisoning are not always available as well so they may show a limited success rate. Fresh frozen plasma (FFP) is one of...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-09-01
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| Series: | Asia Pacific Journal of Medical Toxicology |
| Subjects: | |
| Online Access: | http://apjmt.mums.ac.ir/article_13826_957ab2dd5e5600890d54913848dce8a7.pdf |
| _version_ | 1811296085204795392 |
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| author | Ola Nafea Mohamed Aziz Fatma Saptan Ahmed Abdalla Hend Ibrahim |
| author_facet | Ola Nafea Mohamed Aziz Fatma Saptan Ahmed Abdalla Hend Ibrahim |
| author_sort | Ola Nafea |
| collection | DOAJ |
| description | <em>Background:</em>Organophosphate (OP) poisoning is still a major health concern in both developed and developing countries. The standard treatment approaches of (OP) poisoning are not always available as well so they may show a limited success rate. Fresh frozen plasma (FFP) is one of Bio-scavengers that have been suggested as a useful therapy through elimination of free organophosphates. Therefore, this systematic review and meta-analysis was conducted to update the present evidence about the efficacy of FFP in management of acute OP-intoxicated patients.<br /> <em>Method:</em>A computer literature search of PubMed and Scopus was conducted to identify the relevant randomized controlled trials (RCTs). In addition, a manual search of reference lists of the retrieved articles was conducted. Relevant outcomes were pooled as mean difference (MD) risk ratio (RR) by RevMan version 5.3 for Windows.<br /> <em>Results:</em>Pooled data from 3 RCTs (169 patients) showed that adding FFP to conventional therapy to acutely OP intoxicated patients did not improve clinical outcomes regarding total atropine (MD = 35.05, 95% CI = [-41.14 to 111.24], P-value = 0.37) and pralidoxime dosages (MD = -0.41, 95% CI = [-2.34 to 1.51], P-value = 0.67), length of hospital stay (MD = -2.08, 95% CI = [-4.51 to 0.35], P-value = 0.09) and mortality (RR = 0.42, 95% CI = [0.14 to 1.27], P-value = 0.12).<br /> <em>Conclusion:</em> Fresh frozen plasma did not provide any additional benefit in acutely-OP intoxicated patients compared to the conventional therapy. The limited number and sizes of the included trials are the most probable cause of such effects. |
| first_indexed | 2024-04-13T05:43:06Z |
| format | Article |
| id | doaj.art-88927cd20be14217b5f93da131d346c9 |
| institution | Directory Open Access Journal |
| issn | 2322-2611 2322-4320 |
| language | English |
| last_indexed | 2024-04-13T05:43:06Z |
| publishDate | 2019-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Pacific Journal of Medical Toxicology |
| spelling | doaj.art-88927cd20be14217b5f93da131d346c92022-12-22T03:00:02ZengMashhad University of Medical SciencesAsia Pacific Journal of Medical Toxicology2322-26112322-43202019-09-01839510010.22038/apjmt.2019.1382613826Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-AnalysisOla Nafea0Mohamed Aziz1Fatma Saptan2Ahmed Abdalla3Hend Ibrahim4Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, EgyptAbbasiya Psychiatric Hospital, Cairo, EgyptDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, EgyptFaculty of Medicine, Mansura University, Mansura, EgyptDepartment of Environmental and Radiological Health Sciences, Colorado State, Fort Collins, CO, USA<em>Background:</em>Organophosphate (OP) poisoning is still a major health concern in both developed and developing countries. The standard treatment approaches of (OP) poisoning are not always available as well so they may show a limited success rate. Fresh frozen plasma (FFP) is one of Bio-scavengers that have been suggested as a useful therapy through elimination of free organophosphates. Therefore, this systematic review and meta-analysis was conducted to update the present evidence about the efficacy of FFP in management of acute OP-intoxicated patients.<br /> <em>Method:</em>A computer literature search of PubMed and Scopus was conducted to identify the relevant randomized controlled trials (RCTs). In addition, a manual search of reference lists of the retrieved articles was conducted. Relevant outcomes were pooled as mean difference (MD) risk ratio (RR) by RevMan version 5.3 for Windows.<br /> <em>Results:</em>Pooled data from 3 RCTs (169 patients) showed that adding FFP to conventional therapy to acutely OP intoxicated patients did not improve clinical outcomes regarding total atropine (MD = 35.05, 95% CI = [-41.14 to 111.24], P-value = 0.37) and pralidoxime dosages (MD = -0.41, 95% CI = [-2.34 to 1.51], P-value = 0.67), length of hospital stay (MD = -2.08, 95% CI = [-4.51 to 0.35], P-value = 0.09) and mortality (RR = 0.42, 95% CI = [0.14 to 1.27], P-value = 0.12).<br /> <em>Conclusion:</em> Fresh frozen plasma did not provide any additional benefit in acutely-OP intoxicated patients compared to the conventional therapy. The limited number and sizes of the included trials are the most probable cause of such effects.http://apjmt.mums.ac.ir/article_13826_957ab2dd5e5600890d54913848dce8a7.pdfatropinefresh frozen plasmameta-analysisorganophosphatepralidoxime |
| spellingShingle | Ola Nafea Mohamed Aziz Fatma Saptan Ahmed Abdalla Hend Ibrahim Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis Asia Pacific Journal of Medical Toxicology atropine fresh frozen plasma meta-analysis organophosphate pralidoxime |
| title | Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis |
| title_full | Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis |
| title_fullStr | Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis |
| title_short | Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis |
| title_sort | effectiveness of fresh frozen plasma in management of acute organophosphate intoxicated patients an updated systematic review and meta analysis |
| topic | atropine fresh frozen plasma meta-analysis organophosphate pralidoxime |
| url | http://apjmt.mums.ac.ir/article_13826_957ab2dd5e5600890d54913848dce8a7.pdf |
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