Mice Treated Subcutaneously with Mouse LPS-Converted PrP<sup>res</sup> or LPS Alone Showed Brain Gene Expression Profiles Characteristic of Prion Disease

Mice Treated Subcutaneously with Mouse LPS-Converted PrP<sup>res</sup> or LPS Alone Showed Brain Gene Expression Profiles Characteristic of Prion Disease

Previously, we showed that bacterial lipopolysaccharide (LPS) converts mouse PrP<sup>C</sup> protein to a beta-rich isoform (moPrP<sup>res</sup>) resistant to proteinase K. In this study, we aimed to test if the LPS-converted PrP<sup>res</sup> is infectious and al...

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Bibliographic Details
Main Authors: Dagnachew Hailemariam, Seyed Ali Goldansaz, Nathalie Daude, David S. Wishart, Burim N. Ametaj
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Veterinary Sciences
Subjects:
mice
prion
lipopolysaccharide
brain genes
RML
Online Access:https://www.mdpi.com/2306-7381/8/9/200

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