Coherence analysis discriminates between retroviral integration patterns in CD34+ cells transduced under differing clinical trial conditions

Coherence analysis discriminates between retroviral integration patterns in CD34+ cells transduced under differing clinical trial conditions

Unequivocal demonstration of the therapeutic utility of γ-retroviral vectors for gene therapy applications targeting the hematopoietic system was accompanied by instances of insertional mutagenesis. These events stimulated the ongoing development of putatively safer integrating vector systems and a...

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Detalhes bibliográficos
Main Authors: Claus V Hallwirth, Gagan Garg, Timothy J Peters, Belinda A Kramer, Nirav V Malani, Jessica Hyman, Xiaoan Ruan, Samantha L Ginn, Nicola A Hetherington, Lavanya Veeravalli, Atif Shahab, Shoba Ranganathan, Chia-Lin Wei, Christopher Liddle, Adrian J Thrasher, Frederic D Bushman, Michael J Buckley, Ian E Alexander
Formato: Artigo
Idioma:English
Publicado em: Elsevier 2015-01-01
Colecção:Molecular Therapy: Methods & Clinical Development
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2329050116300274

Internet

http://www.sciencedirect.com/science/article/pii/S2329050116300274

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